当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Amphotericin B-incorporated polymeric micelles composed of poly(d,l-lactide-co-glycolide)/dextran graft copolymer.

Amphotericin B-incorporated polymeric micelles composed of poly(d,l-lactide-co-glycolide)/dextran graft copolymer.

Abstract：

:In this study, we prepared amphotericin B (AmpB)-encapsulated polymeric micelle of poly(d,l-lactide-co-glycolide) (PLGA) grafted-dextran (DexLG) copolymer and characterized its physicochemical properties in vitro. The average particle size of AmpB-encpasulated DexLG polymeric micelles was around 30-150nm while particle size of empty polymeric micelles was below 100nm according to the copolymer composition. The morphology of AmpB-encapsulated polymeric micelle of DexLG copolymer was spherical shapes at transmission electron microscopy (TEM) observation. At 1H NMR study, specific peaks of AmpB and DexLG copolymer was obtained at DMSO but specific peaks characterized to AmpB and PLGA was disappeared at D2O environment. These results indicated that AmpB was encapsulated into the micellar core of polymeric micelle. XRD results also support these results, indicating that specific crystal peaks of AmpB and broad peaks of DexLG copolymer were obtained but specific peaks of AmpB was disappeared at polymeric micelles while physical mixture of AmpB/empty polymeric micelles showed both specific peaks. Drug release rate was decreased according to the increase of drug contents and increase of PLGA component of DexLG copolymer. At the minimal inhibition concentration (MIC) study using Candida albicans, AmpB-encapsulated polymeric micelle showed almost similar effectives on the growth inhibition of microorganisms. These showed that AmpB-encapsulated polymeric micelle of DexLG copolymer can be considered to potential antifungal agent carriers.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Choi KC,Bang JY,Kim PI,Kim C,Song CE

doi

10.1016/j.ijpharm.2007.12.011

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

224-30

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(07)01039-3

journal_volume

355

pub_type

杂志文章

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