Abstract：
:A novel, efficient delivery system for iron (Fe2+) was developed using the alginate biopolymer. Iron loaded alginate nanoparticles were synthesized by a controlled ionic gelation method and was characterized with respect to particle size, zeta potential, morphology and encapsulation efficiency. Successful loading was confirmed with Fourier Transform Infrared spectroscopy and Thermogravimetric Analysis. Electron energy loss spectroscopy study corroborated the loading of ferrous into the alginate nanoparticles. Iron encapsulation (70%) was optimized at 0.06% Fe (w/v) leading to the formation of iron loaded alginate nanoparticles with a size range of 15-30nm and with a negative zeta potential (-38mV). The in vitro release studies showed a prolonged release profile for 96h. Release of iron was around 65-70% at pH of 6 and 7.4 whereas it was less than 20% at pH 2.The initial burst release upto 8h followed zero order kinetics at all three pH values. All the release profiles beyond 8h best fitted the Korsmeyer-Peppas model of diffusion. Non Fickian diffusion was observed at pH 6 and 7.4 while at pH 2 Fickian diffusion was observed.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Katuwavila NP,Perera AD,Dahanayake D,Karunaratne V,Amaratunga GA,Karunaratne DNdoi
10.1016/j.ijpharm.2016.09.053subject
Has Abstractpub_date
2016-11-20 00:00:00pages
404-409issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(16)30883-3journal_volume
513pub_type
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