当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate.

In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate.

Abstract：

:We demonstrate a rapidly formed cubic liquid crystalline phase, i.e. typically 1g cubic phase in less than 1 min confirmed by X-ray diffraction, consisting of an ether lipid, 1-glyceryl monooleyl ether (GME), an aprotic solvent (propylene glycol or pentane-1,5-diol) and water. The efficacy of the cubic formulation was tested in vivo by administrating formulations containing 3% (w/w) of the HCl salts of δ-aminolevulinic acid (ALA) or methylaminolevulinate (MAL) to hairless mice. The endogenous formation of protoporphyrin IX (PpIX) was monitored spectrophotometrically as a marker for cellular uptake of active compound. As reference, a commercial product containing 16% (w/w) MAL in an oil-in-water emulsion (Metvix(®)), and a cubic phase based on an ester lipid (glyceryl monooleate, GMO), previously shown to facilitate topical delivery of both ALA and MAL, were applied. It was found that in general the cubic phases gave rise to higher fluorescence levels than the mice exposed to the commercial product. The instantly formed cubic formulations based on GME demonstrated the same efficiency as the GMO based formulations. The results imply that instantly formed cubic formulations opens up new opportunities, particularly for transdermal drug delivery of substances subject to stability problems in, e.g. aqueous environments.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Evenbratt H,Jonsson C,Faergemann J,Engström S,Ericson MB

doi

10.1016/j.ijpharm.2013.05.047

subject

Has Abstract

pub_date

2013-08-16 00:00:00

pages

270-5

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(13)00464-X

journal_volume

452

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • First explanations for differences in electrotransfection efficiency in vitro and in vivo using spheroid model.

    abstract：:Electro-gene-therapy is a promising technique for cancer treatment. However, knowledge about mechanism of gene transfer with electric field in tumor is limited. Whereas in vitro electrotransfection is efficient, gene expression in tumoral cells in vivo is weak. To determine reasons for this difference and unravel gene...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.04.054

    authors： Chopinet L,Wasungu L,Rols MP

    更新日期：2012-02-14 00:00:00

  • A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery.

    abstract：:The present study evaluates the effect of L-leucine concentration and operating parameters of a laboratory spray dryer on characteristics of trehalose dry powders, with the goal of optimizing production of these powders for inhaled drug delivery. Trehalose/L-leucine mixtures were spray dried from aqueous solution usin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.03.004

    authors： Focaroli S,Mah PT,Hastedt JE,Gitlin I,Oscarson S,Fahy JV,Healy AM

    更新日期：2019-05-01 00:00:00

  • WITHDRAWN: Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays.

    abstract：:This article has been withdrawn at the request of the authors. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.11.046

    authors： Demir YK,Akan Z,Kerimoglu O

    更新日期：2012-12-20 00:00:00

  • Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation.

    abstract：:The aim of this study was to investigate the ability of L-leucine (LL) in preventing moisture-induced deterioration in the in vitro aerosolization performance of spray-dried (SD) salbutamol sulfate (SS). Increasing mass fraction of LL (5-80%) were co-spray dried with SS, and the physicochemical properties of the powde...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.033

    authors： Li L,Leung SSY,Gengenbach T,Yu J,Gao GF,Tang P,Zhou QT,Chan HK

    更新日期：2017-09-15 00:00:00

  • Poly(ε-caprolactone)/triclosan loaded polylactic acid nanoparticles composite: A long-term antibacterial bionanocomposite with sustained release.

    abstract：:In this study, the antibacterial bionanocomposites of poly(ε-caprolactone) (PCL) with different concentrations of triclosan (TC) loaded polylactic acid (PLA) nanoparticles (30wt% triclosan) (LATC30) were fabricated via a melt mixing process in order to lower the burst release of PCL and to extend the antibacterial act...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.009

    authors： Kaffashi B,Davoodi S,Oliaei E

    更新日期：2016-07-11 00:00:00

  • A skin permeability model of insulin in the presence of chemical penetration enhancer.

    abstract：:Enhancing transdermal delivery of insulin using chemical penetration enhancers (CPEs) has several advantages over other non-traditional methods; however, lack of suitable predictive models, make experimentation the only alternative for discovering new CPEs. To address this limitation, a quantitative structure-property...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.12.028

    authors： Yerramsetty KM,Neely BJ,Madihally SV,Gasem KA

    更新日期：2010-03-30 00:00:00

  • Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: Innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time.

    abstract：:Achieving drug delivery at the ocular level encounters many challenges and obstacles. In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment of a wide range of ocular diseases. The present work describes the formulation and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118734

    authors： Destruel PL,Zeng N,Seguin J,Douat S,Rosa F,Brignole-Baudouin F,Dufaÿ S,Dufaÿ-Wojcicki A,Maury M,Mignet N,Boudy V

    更新日期：2020-01-25 00:00:00

  • Saturation solubility of nicotine, scopolamine and paracetamol in model stratum corneum lipid matrices.

    abstract：:The saturation solubilities of nicotine and scopolamine bases as well as acidic paracetamol were measured in two different model stratum corneum lipid matrices. Light microscopy visualized the presence of drug above its solubility either as droplets or crystalline particles. Neither wide-angle X-ray diffraction nor DS...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.06.057

    authors： Mundstock A,Lee G

    更新日期：2014-10-01 00:00:00

  • Crystallization rate of amorphous nifedipine analogues unrelated to the glass transition temperature.

    abstract：:To examine the relative contributions of molecular mobility and thermodynamic factor, the relationship between glass transition temperature (T(g)) and the crystallization rate was examined using amorphous dihydropyridines (nifedipine (NFD), m-nifedipine (m-NFD), nitrendipine (NTR) and nilvadipine (NLV)) with differing...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.11.052

    authors： Miyazaki T,Yoshioka S,Aso Y,Kawanishi T

    更新日期：2007-05-04 00:00:00

  • Applications of NIR spectroscopy to monitoring and analyzing the solid state during industrial crystallization processes.

    abstract：:Fiber-optic near infrared (NIR) spectroscopy was used to investigate several key features of the polymorphic transitions observed during the crystallization and the filtration of SaC, an Active Pharmaceutical Ingredient (API) produced by Sanofi-Synthelabo. Using few samples, the spectroscopic data were calibrated to p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.003

    authors： Févotte G,Calas J,Puel F,Hoff C

    更新日期：2004-04-01 00:00:00

  • Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: Design, characterization and in vivo pharmacokinetic evaluation.

    abstract：:This paper describes design and evaluation of parenteral lecithin-based nanoemulsions intended for brain delivery of risperidone, a poorly water-soluble psychopharmacological drug. The nanoemulsions were prepared through cold/hot high pressure homogenization and characterized regarding droplet size, polydispersity, su...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.007

    authors： Đorđević SM,Cekić ND,Savić MM,Isailović TM,Ranđelović DV,Marković BD,Savić SR,Timić Stamenić T,Daniels R,Savić SD

    更新日期：2015-09-30 00:00:00

  • Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution.

    abstract：:Superdisintegrants are a key excipient used in immediate release formulations to promote fast tablet disintegration, therefore understanding the impact of superdisintegrant variability on product performance is important. The current study examined the impact of superdisintegrant critical material attributes (viscosit...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119080

    authors： Zarmpi P,Flanagan T,Meehan E,Mann J,Fotaki N

    更新日期：2020-03-15 00:00:00

  • Preparation of osthole-polymer solid dispersions by hot-melt extrusion for dissolution and bioavailability enhancement.

    abstract：:The aim of this study was to investigate the potential of solid dispersion to improve the dissolution rate and bioavailability of osthole (Ost), a coumarin derivative with various pharmacological activities but with poor aqueous solubility. In present studies, the Ost solid dispersions were prepared with various polym...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.040

    authors： Yun F,Kang A,Shan J,Zhao X,Bi X,Li J,Di L

    更新日期：2014-04-25 00:00:00

  • NaCl strongly modifies the physicochemical properties of aluminum hydroxide vaccine adjuvants.

    abstract：:The immunostimulation capacity of most vaccines is enhanced through antigen adsorption on aluminum hydroxide (AH) adjuvants. Varying the adsorption conditions, i.e. pH and ionic strength (I), changes the antigen adsorbed amount and therefore the ability of the vaccine to stimulate the immune system. Vaccine formulatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.12.019

    authors： Art JF,Vander Straeten A,Dupont-Gillain CC

    更新日期：2017-01-30 00:00:00

  • Biodisposition of PEG-coated lipid microspheres of indomethacin in arthritic rats.

    abstract：:Conventional lipid microspheres (LM) were prepared using soybean oil and lipid at a 5.5:1 weight ratio with lipid phase consisting of PC (phosphatidyl choline):CH (cholesterol) (1:0.5) by molar ratio. The average diameter of the particles was 150 nm. Long-circulating microspheres (S-LM) were also prepared similarly bu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.11.017

    authors： Palakurthi S,Vyas SP,Diwan PV

    更新日期：2005-02-16 00:00:00

  • Nanoemulsion enhances α-tocopherol succinate bioavailability in rats.

    abstract：:The vitamin E analogue, α-tocopherol succinate (α-TOS), has a broad anti-tumor effect. α-TOS can induce cancer cells apoptosis and suppress tumor growth by targeting mitochondria. Low bioavailability of α-TOS is the major problem encountered with formulation development. In our study, α-TOS nanoemulsion (α-TOS-NE) was...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.10.026

    authors： Gao Y,Qi X,Zheng Y,Ji H,Wu L,Zheng N,Tang J

    更新日期：2016-12-30 00:00:00

  • Folic acid transport via high affinity carrier-mediated system in human retinoblastoma cells.

    abstract：:The primary objective of this study was to investigate the expression of a specialized carrier-mediated system for folic acid and to delineate its uptake mechanism and intracellular trafficking in a human derived retinoblastoma cell line (Y-79). Uptake of [3H]Folic acid was determined at various concentrations, pH, te...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.008

    authors： Kansara V,Paturi D,Luo S,Gaudana R,Mitra AK

    更新日期：2008-05-01 00:00:00

  • Critical quality attributes, in vitro release and correlated in vitro skin permeation-in vivo tape stripping collective data for demonstrating therapeutic (non)equivalence of topical semisolids: A case study of "ready-to-use" vehicles.

    abstract：:This work aimed to prove the ability of "ready-to-use" topical vehicles based on alkyl polyglucoside-mixed emulsifier (with/without co-solvent modifications) to replace the conventionally used pharmacopoeial bases (e.g., non-ionic hydrophilic cream) in compounding practice. For this purpose, considering the regulatory...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.06.018

    authors： Ilić T,Pantelić I,Lunter D,Đorđević S,Marković B,Ranković D,Daniels R,Savić S

    更新日期：2017-08-07 00:00:00

  • Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers.

    abstract：:The objectives of this study were to describe the pharmacokinetics and tissue distribution of superparamagnetic iron oxide nanoparticle (SPIO) stabilized with alginate (SPIO-alginate), and investigate its potential in detecting liver cancers as a newly developed magnetic resonance (MR) contrast agent. Pharmacokinetics...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.11.036

    authors： Ma HL,Xu YF,Qi XR,Maitani Y,Nagai T

    更新日期：2008-04-16 00:00:00

  • Determination of nifedipine in human plasma and its use in bioequivalence study.

    abstract：:A sensitive atmospheric pressure chemical ionization liquid chromatographic-mass spectrometric (APCI-LC-MS) assay with positive ion mode has been developed for the determination of nifedipine in human plasma. In this method, nifedipine was extracted from human plasma using diethyl ether with dimethoxanate as the inter...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2007.03.053

    authors： Guo Y,Dai J,Qian G,Guo N,Ma Z,Guo X

    更新日期：2007-08-16 00:00:00

  • Inertial sizing of aerosol inhaled from two dry powder inhalers with realistic breath patterns versus constant flow rates.

    abstract：:A procedure is developed that allows particles inhaled with realistic breath patterns to be sized by cascade impaction at a constant flow rate. This procedure is then used to examine the difference between particle sizes obtained with constant flow rate (step profile) versus actual-subject breath patterns for two dry ...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0378-5173(00)00569-x

    authors： Finlay WH,Gehmlich MG

    更新日期：2000-12-04 00:00:00

  • Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces.

    abstract：:Acylation of proteins with a fatty acid chain has proven useful for prolonging the plasma half-lives of proteins. In formulation of acylated protein drugs, knowledge about the effect of acylation with fatty acids on the adsorption behaviour of proteins at interfaces will be valuable. The aim of this work was to study ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.01.040

    authors： Pinholt C,Kapp SJ,Bukrinsky JT,Hostrup S,Frokjaer S,Norde W,Jorgensen L

    更新日期：2013-01-02 00:00:00

  • Prediction of aqueous solubility of drug-like molecules using a novel algorithm for automatic adjustment of relative importance of descriptors implemented in counter-propagation artificial neural networks.

    abstract：:In this work, we present a novel approach for the development of models for prediction of aqueous solubility, based on the implementation of an algorithm for the automatic adjustment of descriptor's relative importance (AARI) in counter-propagation artificial neural networks (CPANN). Using this approach, the interpret...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.08.022

    authors： Erić S,Kalinić M,Popović A,Zloh M,Kuzmanovski I

    更新日期：2012-11-01 00:00:00

  • Direct quantification of unencapsulated doxorubicin in liposomal doxorubicin formulations using capillary electrophoresis.

    abstract：:To understand the quality, efficacy, and safety of liposomal drugs, it is necessary to develop a robust and accurate method for the separation and the quantification of unencapsulated and liposome-associated drugs (or liposomal encapsulated drugs). Conventional methods involve separation of unencapsulated and liposome...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.07.019

    authors： Ansar SM,Jiang W,Mudalige T

    更新日期：2018-10-05 00:00:00

  • Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells.

    abstract：:Efficient delivery of small interfering RNA (siRNA) remains a challenging task in RNA interference (RNAi) studies. In this study, we used chitosan-graft-polyethylenimine (CHI-g-PEI) copolymer composed of chitosan and low molecular weight polyethylenimine (PEI) for the delivery of siRNA. The CHI-g-PEI carrier formed st...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.05.046

    authors： Jere D,Jiang HL,Kim YK,Arote R,Choi YJ,Yun CH,Cho MH,Cho CS

    更新日期：2009-08-13 00:00:00

  • Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro.

    abstract：:Development of novel anticancer formulations is a priority challenge in biomedicine. However, in vitro models based on monolayer cultures (2D) which are currently used for cytotoxicity tests leave much to be desired. More and more attention is focusing on 3D in vitro systems which can better mimic solid tumors. The ai...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.04.005

    authors： Akasov R,Zaytseva-Zotova D,Burov S,Leko M,Dontenwill M,Chiper M,Vandamme T,Markvicheva E

    更新日期：2016-06-15 00:00:00

  • Drug interactions with diosmectite: a study using the artificial stomach-duodenum model.

    abstract：:Drug interactions with diosmectite, a gastric-protective drug, were studied in vitro using an artificial stomach-duodenum model. The behavior of neutral and ionisable drugs with pKa values ranging between 2 and 8 was monitored to determine the physicochemical characteristics of the interactions. The main neutral (digo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00073-3

    authors： Castela-Papin N,Cai S,Vatier J,Keller F,Souleau CH,Farinotti R

    更新日期：1999-05-10 00:00:00

  • Uptake and biodistribution of rizatriptan to blood and brain following different routes of administration in rats.

    abstract：:The objective of the present study was to investigate the biodistribution profiles of rizatriptan in the blood and brain of Wistar rats after peroral, subcutaneous, intranasal and intratracheal administration with a particular view to determining the applicability of inhalation delivery to achieve rapid and high avail...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.12.039

    authors： Wang C,Quan LH,Guo Y,Liu CY,Liao YH

    更新日期：2007-06-07 00:00:00

  • Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect.

    abstract：:Cutanvoa Nanorepair Q10 cream, the first NLC containing cosmetical product introduced to the market in October 2005, was compared to an identical o/w cream without NLC with regards to particle size, melting behaviour, rheological properties and the in vivo effect on skin hydration. The consistency, the spreadability o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.06.007

    authors： Pardeike J,Schwabe K,Müller RH

    更新日期：2010-08-30 00:00:00

  • Evaluation of the efficacy and toxicity of amphotericin B incorporated in lipid nano-sphere (LNS).

    abstract：:To develop a low-dose therapeutic system for amphotericin B (AmB), the efficacy and toxicity of lipid nano-sphere (LNS) incorporating AmB (LNS-AmB) were evaluated and compared with those of Fungizone, the conventional dosage form of AmB with sodium deoxycholate. LNS-AmB and Fungizone showed nearly equal activity again...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00342-9

    authors： Fukui H,Koike T,Saheki A,Sonoke S,Tomii Y,Seki J

    更新日期：2003-09-16 00:00:00