Abstract:
:Diabetic foot infections are the most common complications requiring hospitalisation of patients with diabetes. They often result in amputation to extremities and are associated with high morbi-mortality rates, especially when bone is infected. Treatment of these complications is based on surgical procedures, nursing care and systemic antibiotic therapy for several weeks, with a significant risk of relapse. Due to low blood flow and damage caused by diabetic foot infection, blood supply is decreased, causing low antibiotic diffusion in the infected site and an increase of possible bacterial resistance, making this type of infection particularly difficult to treat. In this context, the aim of this work was to develop a medical device for local antibiotic release. The device is a lyophilized physical hydrogel, i.e a sponge based on two oppositely charged polyelectrolytes (chitosan and poly(cyclodextrin citrate)). Cyclodextrins, via inclusion complexes, increase drug bioavailability and allow an extended release. Using local release administration increases concentrations in the wound without risk of toxicity to the body and prevents the emergence of resistant bacteria. The hydrogel was characterised by rheology. After freeze-drying, a curing process was implemented. The swelling rate and cell viability were evaluated, and finally, the sponge was impregnated with a ciprofloxacin solution to evaluate its drug release profile and its antibacterial activity.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Gauzit Amiel A,Palomino-Durand C,Maton M,Lopez M,Cazaux F,Chai F,Neut C,Foligné B,Martel B,Blanchemain Ndoi
10.1016/j.ijpharm.2020.119677subject
Has Abstractpub_date
2020-09-25 00:00:00pages
119677eissn
0378-5173issn
1873-3476pii
S0378-5173(20)30661-Xjournal_volume
587pub_type
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