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Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system.

Abstract：

:Interleukin-10 (IL-10) is an anti-inflammatory cytokine, which active form is a non-covalent homodimer with two intramolecular disulphide bonds essential for its biological activity. A mutated form of murine IL-10 was successfully expressed in E. coli, recovered and purified from inclusion bodies. Its ability to reduce tumor necrosis factor α synthesis and down-regulate class II major histocompatibility complex molecules expression on endotoxin-stimulated bone marrow-derived macrophages was confirmed, and shown to be similar to that of a commercially available IL-10. Given the potential of IL-10 for application in various medical conditions, it is essential to develop systems that can effectively deliver the protein. In this work it is shown that a dextrin nanogel effectively incorporate IL-10, stabilize, and enable the slow release of biologically active IL-10 over time. Altogether, these results demonstrate the suitability of dextrin nanogel to be used as a system for the controlled release of IL-10.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Carvalho V,Castanheira P,Faria TQ,Gonçalves C,Madureira P,Faro C,Domingues L,Brito RM,Vilanova M,Gama M

doi

10.1016/j.ijpharm.2010.08.040

subject

Has Abstract

pub_date

2010-11-15 00:00:00

pages

234-42

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(10)00670-8

journal_volume

400

pub_type

杂志文章

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