Abstract：
:Immune stimulating complexes and/or ISCOM matrices (adjuvant nanoparticles without antigen as a structural component) found potential applications as nasal vaccine adjuvant/delivery system owing to virus like particulate structure and saponin as potent Th1 adjuvant. One of important limiting factor for nasal vaccine delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. In this report the clearance rate of ISCOM matrices from nasal cavity of rabbit was determined by gamma scintigraphy. ISCOM matrices were radiolabelled with (99m)Tc by direct labelling method using stannous chloride as a reducing agent. (99m)Tc labelled ISCOM matrices were administered into the nostril of female New Zealand rabbits and 1 min static views were repeated each 15 min until 4h. Clearance rate of ISCOM matrices from nasal cavity was calculated after applying the physical decay corrections. The mean labelling efficiency for ISCOM matrices were calculated as approximately 58.4%. ISCOM matrices showed slower clearance rate compared to sodium pertechnetate control solution (p<0.005) from nasal cavity that may be due to particulate and hydrophobic characters of ISCOM particles even though it was also cleared within 4h from nasal cavity. Mucoadhesive ISCOM formulations that retain in nasal cavity for longer duration of time may reduce the dose/frequency of vaccine for nasal immunization.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Pandey RS,Babbar AK,Kaul A,Mishra AK,Dixit VKdoi
10.1016/j.ijpharm.2010.07.051subject
Has Abstractpub_date
2010-10-15 00:00:00pages
231-6issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(10)00578-8journal_volume
398pub_type
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