Abstract：
:Vesicular systems have shown their ability to increase dermal and transdermal drug delivery. Their mechanism of drug transport into and through the skin has been investigated but remains a much debated question. Several researchers have outlined that drug penetration can be influenced by modifying the surface charge of liposomes. In the present work we study the influence of particle surface charge on skin penetration. The final purpose is the development of a carrier system which is able to enhance the skin delivery of two model drugs, betamethasone and betamethasone dipropionate. Liposomes were characterised by their size, morphology, zeta potential, encapsulation efficiency and stability. Ex vivo diffusion studies using Franz diffusion cells were performed. Confocal microscopy was performed to visualise the penetration of fluorescently labelled liposomes into the skin. This study showed the potential of negatively charged liposomes to enhance the skin penetration of betamethasone and betamethasone dipropionate.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Gillet A,Compère P,Lecomte F,Hubert P,Ducat E,Evrard B,Piel Gdoi
10.1016/j.ijpharm.2011.03.049subject
Has Abstractpub_date
2011-06-15 00:00:00pages
223-31issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)00266-3journal_volume
411pub_type
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