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Preparation and characterization of Chinese yam polysaccharide PLGA nanoparticles and their immunological activity.

Abstract：

:This paper first provides that Chinese yam polysaccharide (CYP) is encapsulated by PLGA using a double emulsion solvent evaporation method and aims to screen the optimal preparation of CYP-PLGA nanoparticles (CYPP) using response surface methodology (RSM). The volume ratio of the internal water phase to the organic phase (W1:O), the volume ratio of the primary emulsion to the external water phase (PE:W2) and the concentration of Poloxamer 188 (F68) are deemed key variables for the encapsulation efficiency of CYPP. The results demonstrated that the data were accurately fitted into the RSM model. According to the RSM, the optimal scheme was a volume ratio of W1:O of 1:9, a volume ratio of PE: W2 of 1:10 and a concentration of F68 (W/V) of 0.7%. TEM and SEM images demonstrated that the nanoparticles had a spherical shape and smooth surface. The CYP and CYPP in vitro release studies demonstrated that the CYPP showed a release rate 53.41% lower than the release rate of CYP after 48h. The result of pro-proliferation and flow cytometry emerged that the CYPP were more effective compared with the free CYP and blank PLGA nanoparticles in promoting lymphocyte proliferation and triggering the transformation of T lymphocytes into Th cells.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Luo L,Zheng S,Huang Y,Qin T,Xing J,Niu Y,Bo R,Liu Z,Huang Y,Hu Y,Liu J,Wu Y,Wang D

doi

10.1016/j.ijpharm.2016.06.130

subject

Has Abstract

pub_date

2016-09-10 00:00:00

pages

140-150

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(16)30620-2

journal_volume

511

pub_type

杂志文章

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