Abstract：
:Chitosan (CH) was dissolved in aqueous solutions containing aspartic, glutamic, hydrochloric, lactic and citric acids to obtain different chitosan salts. Chitosan salts were collected from the solutions by spray-drying and the powders obtained were mixed with Sodium Diclofenac (SD), taken as a model anti-inflammatory drug. This study evaluated in vitro the influence of acid type on the release behaviour of SD from the physical mixture during gastrointestinal transit. The physical mixture of the chitosan salts with SD provided slower drug release than the pure drug both in acidic and alkaline pHs. In addition, the interaction with beta-glucosidase at pH 7.0 enhanced the release rate. Among the CH salts used, glutamic and aspartic salts provided the best control of release.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Orienti I,Cerchiara T,Luppi B,Bigucci F,Zuccari G,Zecchi Vdoi
10.1016/s0378-5173(02)00060-1keywords:
subject
Has Abstractpub_date
2002-05-15 00:00:00pages
51-9issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517302000601journal_volume
238pub_type
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