A novel method to measure the glass and melting transitions of pharmaceutical powders.

Abstract:

:A method to measure thermo-mechanical properties of pharmaceutical and polymeric powders was developed. The measurements are conducted by characterizing the material's response to applied acoustic waves. Measurements were performed using griseofulvin, felodipine and indomethacin as model drugs and polyethylene oxide (MW=200,000, 900,000, 2,000,000Da) as model polymers. The method employed measures the mechanical impedance enabled the calculation of the powder rheological and thermo-mechanical properties. Measurements attained with this new technique are compared with measurements made using differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). The new method detects the melting and glass transitions events while providing complementary information to that provided by DSC and DMA.

journal_name

Int J Pharm

authors

Abiad MG,Gonzalez DC,Mert B,Campanella OH,Carvajal MT

doi

10.1016/j.ijpharm.2010.06.001

subject

Has Abstract

pub_date

2010-08-30 00:00:00

pages

23-9

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(10)00409-6

journal_volume

396

pub_type

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