当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Green fabricated reduced graphene oxide: evaluation of its application as nano-carrier for pH-sensitive drug delivery.

Green fabricated reduced graphene oxide: evaluation of its application as nano-carrier for pH-sensitive drug delivery.

Abstract：

:A green and mild approach for the preparation of reduced graphene oxide (rGO) was proposed by using riboflavin-5'-phosphate sodium salt dihydrate as a reducing reagent and stabilizer without any other reagent. The fabricated nano-rGO was systematically evaluated for its application as nano-carrier for pH-sensitive drug delivery. The hemolytic toxicity test indicated the as-prepared nano-rGO had negligible hemolytic activity, which demonstrating its safety in drug delivery system. Doxorubicin hydrochloride (DOX) as a model drug was successfully attached onto the surface of nano-rGO via strong π-π stacking interaction. Compared with common carriers, the obtained DOX-loaded nano-rGO nanohybrid exhibited characteristics of high drug loading content, good stability, pH-sensitive and sustainable release of drugs. Cytotoxicity assay results suggested such nanohybrid exhibited effective cytotoxicity to MCF-7 and A549 cells by nonspecific endocytosis mechanism. Therefore, the present green fabricated rGO could be a good candidate as an ideal nano-carrier for drug delivery and controlled release.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Ma N,Zhang B,Liu J,Zhang P,Li Z,Luan Y

doi

10.1016/j.ijpharm.2015.10.081

subject

Has Abstract

pub_date

2015-12-30 00:00:00

pages

984-92

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)30348-3

journal_volume

496

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Evaluation and structure-activity relationship of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network.

    abstract：:The effect of 35 newly synthesized O-ethylmenthol (MET) derivatives on percutaneous absorption of ketoprofen was investigated in rats. In order to understand the relationship between the structure of compounds and promoting activity (structure-activity relationship), an artificial neural network (ANN) was employed. In...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00608-6

    authors： Obata Y,Li CJ,Fujikawa M,Takayama K,Sato H,Higashiyama K,Isowa K,Nagai T

    更新日期：2001-01-16 00:00:00

  • Optimisation of glutathione conjugation to liposomes quantified with a validated HPLC assay.

    abstract：:Glutathione (GSH) grafted onto nanoliposomes (GSH-liposomes) have the potential to enhance drug delivery into the brain. GSH is known to be an unstable tripeptide, however, despite widespread use to promote active transport its stability has been largely ignored to date. Therefore this study focuses on the optimisatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118451

    authors： Reginald-Opara JN,Svirskis D,O'Carroll SJ,Sreebhavan S,Dean JM,Wu Z

    更新日期：2019-08-15 00:00:00

  • Diffusion and binding of 5-fluorouracil in non-ionic hydrogels with interpolymer complexation.

    abstract：:Hydrogen-bonded interpolymer complexes can be used for development of novel dosage forms. In this study, two types of crosslinked hydrogels, copolymer networks of N-vinyl pyrrolidone and acrylamide (PVP-co-PAM) and interpenetrating polymer networks (IPN) composed of crosslinked PVP-co-PAM and poly(vinyl alcohol) (PVA)...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.04.037

    authors： Zhou W,Lu P,Sun L,Ji C,Dong J

    更新日期：2012-07-15 00:00:00

  • The dispersion behaviour of dry powder inhalation formulations cannot be assessed at a single inhalation flow rate.

    abstract：:The dispersion performances of inhalation powders are often tested at only one inhalation flow rate in mechanistic formulation studies. This limited approach is challenged by studies showing that interactions exist between inhalation flow rate and the effects on dispersion performance of several formulation variables....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.024

    authors： Grasmeijer F,de Boer AH

    更新日期：2014-04-25 00:00:00

  • The novel immunogenic chimeric peptide vaccine to elicit potent cellular and mucosal immune responses against HTLV-1.

    abstract：:This study reports on the immunogenicity assessment of a novel chimeric peptide vaccine including Tax, gp21, gp46, and gag immunodominant epitopes of human T-cell lymphotropic virus type 1 (HTLV-1) to induce immunity against HTLV-1 after subcutaneous (SC) or intranasal administration in a mice model. Additionally, to ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.07.069

    authors： Kabiri M,Sankian M,Hosseinpour M,Tafaghodi M

    更新日期：2018-10-05 00:00:00

  • Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions.

    abstract：:An innovative bioadhesive patch intended primarily as a vulval drug delivery system and, specifically, as a means to deliver photosensitisers, or their prodrugs, for photodynamic purposes is described. The patch was formulated with a copolymer of methyl vinyl ether and maleic anhydride (PMVE/MA) as a bioadhesive matri...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.11.035

    authors： McCarron PA,Donnelly RF,Zawislak A,Woolfson AD,Price JH,McClelland R

    更新日期：2005-04-11 00:00:00

  • Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain.

    abstract：:The purpose of this study was to improve the solubility and enhance the brain uptake of nimodipine (NM) in an o/w microemulsion, which was suitable for intranasal delivery. Three microemulsion systems stabilized by the nonionic surfactants either Cremophor RH 40 or Labrasol, and containing a variety of oils, namely is...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.039

    authors： Zhang Q,Jiang X,Jiang W,Lu W,Su L,Shi Z

    更新日期：2004-05-04 00:00:00

  • Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension.

    abstract：:Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using oleic acid, oleylamine and sorbitan monooleate adopting thin film hydration technique. Chitosan HCl was added to impart the mucoadhesive properties to the olaminoso...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.070

    authors： Abd-Elsalam WH,ElKasabgy NA

    更新日期：2019-04-05 00:00:00

  • alpha-Cyclodextrin/oil beads: an innovative self-assembling system.

    abstract：:The aim of this work was to characterise a new type of particulate system, named beads, prepared by a straightforward technique starting from a mixture of alpha-cyclodextrin aqueous solution and soybean oil without the use of any organic solvent or surface-active agent. Mechanisms involved in bead formation were also ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.02.034

    authors： Bochot A,Trichard L,Le Bas G,Alphandary H,Grossiord JL,Duchêne D,Fattal E

    更新日期：2007-07-18 00:00:00

  • A novel antimicrobial peptide-derived vehicle for oligodeoxynucleotide delivery to inhibit TNF-α expression.

    abstract：:Indolicidin (IL), an antimicrobial peptide, was investigated as a vehicle to promote oligodeoxynucleotides (ODNs) delivery. To increase charge density, IL was dimerized by adding a cysteine to its C or N terminus, which was denoted as ILC or CIL, respectively. In contrast to IL, cytotoxicity of ILC and CIL was signifi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.12.082

    authors： Hu WW,Huang SC,Jin SC

    更新日期：2019-03-10 00:00:00

  • Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis.

    abstract：:The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis. Physicochemical characterization of blend MS was assessed using scanning electron microscopy (SEM), Fourier tr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.11.036

    authors： Duan H,Lü S,Qin H,Gao C,Bai X,Wei Y,Wu X,Liu M,Zhang X,Liu Z

    更新日期：2017-01-10 00:00:00

  • Correlation between the stability constant and pH for β-cyclodextrin complexes.

    abstract：:In drug formulations, cyclodextrins are used to increase aqueous solubility and chemical stability of drugs via formation of inclusion complexes. For ionizable drug molecules, the complexation strength depends on pH. Increased ionization leads to a more soluble drug, but also results in destabilization of cyclodextrin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118523

    authors： Samuelsen L,Holm R,Lathuile A,Schönbeck C

    更新日期：2019-09-10 00:00:00

  • Drug interactions with diosmectite: a study using the artificial stomach-duodenum model.

    abstract：:Drug interactions with diosmectite, a gastric-protective drug, were studied in vitro using an artificial stomach-duodenum model. The behavior of neutral and ionisable drugs with pKa values ranging between 2 and 8 was monitored to determine the physicochemical characteristics of the interactions. The main neutral (digo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00073-3

    authors： Castela-Papin N,Cai S,Vatier J,Keller F,Souleau CH,Farinotti R

    更新日期：1999-05-10 00:00:00

  • Melt extrusion with poorly soluble drugs - An integrated review.

    abstract：:Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This revie...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.10.056

    authors： Repka MA,Bandari S,Kallakunta VR,Vo AQ,McFall H,Pimparade MB,Bhagurkar AM

    更新日期：2018-01-15 00:00:00

  • Ex vivo skin permeation and retention studies on chitosan-ibuprofen-gellan ternary nanogel prepared by in situ ionic gelation technique--a tool for controlled transdermal delivery of ibuprofen.

    abstract：:The chemical potentials of drug-polymer electrostatic interaction have been utilized to develop a novel ternary chitosan-ibuprofen-gellan nanogel as controlled transdermal delivery tool for ibuprofen. The ternary nanogels were prepared by a combination of electrostatic nanoassembly and ionic gelation techniques. The e...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.030

    authors： Abioye AO,Issah S,Kola-Mustapha AT

    更新日期：2015-07-25 00:00:00

  • Multi-modal detection of colon malignancy by NIR-tagged recognition polymers and ultrasound contrast agents.

    abstract：:To increase colonoscopy capability to discriminate benign from malignant polyps, we suggest combining two imaging approaches based on targeted polymeric platforms. Water-soluble cationized polyacrylamide (CPAA) was tagged with the near infrared (NIR) dye IR-783-S-Ph-COOH to form Flu-CPAA. The recognition peptide VRPMP...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.11.066

    authors： Bloch M,Jablonowski L,Yavin E,Moradov D,Djavsarov I,Nyska A,Wheatley M,Rubinstein A

    更新日期：2015-01-30 00:00:00

  • Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneously in oral administration.

    abstract：:Lipid nanoparticles (LNs) are widely investigated for oral drug delivery, and for achieving significant advantages in colloidal stability, biocompatibility and scaled-up possibility. However, researchers face challenge of developing methods to improve the ability of LNs in overcoming multiple barriers (i.e., mucus and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.02.015

    authors： Wu L,Liu M,Shan W,Cui Y,Zhang Z,Huang Y

    更新日期：2017-03-30 00:00:00

  • In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate.

    abstract：:We demonstrate a rapidly formed cubic liquid crystalline phase, i.e. typically 1g cubic phase in less than 1 min confirmed by X-ray diffraction, consisting of an ether lipid, 1-glyceryl monooleyl ether (GME), an aprotic solvent (propylene glycol or pentane-1,5-diol) and water. The efficacy of the cubic formulation was...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.05.047

    authors： Evenbratt H,Jonsson C,Faergemann J,Engström S,Ericson MB

    更新日期：2013-08-16 00:00:00

  • Non-viral gene delivery carrier and its three-dimensional transfection system.

    abstract：:An increasing number of non-viral vectors are being developed for the use of gene delivery nowadays, among which cationic polymers and lipoplexes receive most attention. Most of these researches are focused on how to increase the transfection efficiency of non-viral vectors as well as the reduction of toxicity. In thi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2009.11.006

    authors： He CX,Tabata Y,Gao JQ

    更新日期：2010-02-15 00:00:00

  • Effect of nicotinamide on the properties of aqueous HPMC solutions.

    abstract：:The effect of nicotinamide on the properties of aqueous hydroxypropylmethylcellulose (HPMC) solutions was studied. Rheological studies showed that solutions of HPMC of concentration less than 3.0 w/v.% did not form gels and exhibited Newtonian flow patterns at 25 degrees C. The inclusion of nicotinamide increased the ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00770-0

    authors： Hino T,Ford JL

    更新日期：2001-09-11 00:00:00

  • Characterization of nifedipine solid dispersions.

    abstract：:The sublingual administration of nifedipine (NIF) is currently used in clinical practice. The sublingual administration of NIF solid dispersions (SD), by using a suitable dispenser, appears an interesting approach in the treatment of moderate and severe hypertensive emergencies. With this aim nine SD made of NIF and a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00173-4

    authors： Cilurzo F,Minghetti P,Casiraghi A,Montanari L

    更新日期：2002-08-21 00:00:00

  • Differential expression of organic cation transporters in normal and polyps human nasal epithelium: implications for in vitro drug delivery studies.

    abstract：:The aim of this study was to compare the expression of organic cation transporters (OCTs) in normal and polyps nasal epithelium. Primary cell cultures of human nasal epithelium (polyps and normal tissues) were compared by investigating the uptake of a fluorescent organic cation, [4-dimethylaminostyryl-N-methylpyridini...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.12.037

    authors： Agu R,MacDonald C,Cowley E,Shao D,Renton K,Clarke DB,Massoud E

    更新日期：2011-03-15 00:00:00

  • Preparation and characterization of lipid nanoparticle/pDNA complexes for STAT3 downregulation and overcoming chemotherapy resistance in lung cancer cells.

    abstract：:Developments in the field of molecular oncology have revealed that resistance to chemotherapeutics is acqured through several mechanisms including overexpression of common oncogenic proteins. Signal Transducer and Activator of Transcription 3 (STAT3) is one of these oncogenes that is overexpressed in many cancer types...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.04.034

    authors： Kotmakçı M,Çetintaş VB,Kantarcı AG

    更新日期：2017-06-15 00:00:00

  • Preliminary evaluation of a novel oral delivery system for rhPTH1-34: in vitro and in vivo.

    abstract：:rhPTH1-34 is clinically used for osteoporosis treatment. However, this peptide drug has no oral bioavailability because of proteolysis and low membrane permeability in gastrointestinal gut. This study explored the possibility of absorption enhancement for rhPTH1-34 through the oral delivery of the microemulsion. The m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.08.029

    authors： Guo L,Ma E,Zhao H,Long Y,Zheng C,Duan M

    更新日期：2011-11-25 00:00:00

  • In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex.

    abstract：:Although the taste-masking of bitter drug using ion exchange resin has been recognized, in vitro testing using an electronic tongue (e-Tongue) and in vivo bitterness test by human panel test was not fully understood. In case of orally disintegrating tablet (ODT) containing bitter medicine, in vitro and in vivo disinte...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.072

    authors： Kim JI,Cho SM,Cui JH,Cao QR,Oh E,Lee BJ

    更新日期：2013-10-15 00:00:00

  • Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant physically mixed or incorporated.

    abstract：:In a previous study, it was shown that the incorporation of poorly soluble drugs (BCS class II) in sugar glasses could largely increase the drug's dissolution rate [van Drooge, D.J., Hinrichs, W.L.J., Frijlink, H.W., 2004 b. Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.07.023

    authors： de Waard H,Hinrichs WL,Visser MR,Bologna C,Frijlink HW

    更新日期：2008-02-12 00:00:00

  • Production and evaluation of size reduced grades of microcrystalline cellulose.

    abstract：:Size reduction of microcrystalline cellulose (MCC, Avicel PH-101) powder by ball milling was poorly effective, particularly in the presence of sodium lauryl sulphate (SLS), which tended to form a protective foam. Ultrasonic homogenisation of an aqueous suspension more readily produced ultra-fine MCC, even in the prese...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00652-9

    authors： Levis SR,Deasy PB

    更新日期：2001-02-01 00:00:00

  • pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan microspheres.

    abstract：:The aim of this study was using Eudragit-cysteine conjugate to coat on chitosan microspheres (CMs) for developing an oral protein drug delivery system, having mucoadhesive and pH-sensitive property. Bovine serum albumin (BSA) as a protein model drug was loaded in thiolated Eudragit-coated CMs (TECMs) to study the rele...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.04.003

    authors： Quan JS,Jiang HL,Kim EM,Jeong HJ,Choi YJ,Guo DD,Yoo MK,Lee HG,Cho CS

    更新日期：2008-07-09 00:00:00

  • Synthesis and evaluation of styrene-maleic acid copolymer conjugated amphotericin B.

    abstract：:Amphotericin B (AmB), which plays a central role in the treatment of systemic fungal infections, is difficult to formulate because it's sparingly soluble in water and organic solvents. We previously prepared AmB-loaded micelles using styrene-maleic acid copolymer (SMA). Although solubilization was achieved by this for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118719

    authors： Banshoya K,Kaneo Y,Tanaka T,Yamamoto S,Maeda H

    更新日期：2019-12-15 00:00:00

  • Aptamers as the chaperones (Aptachaperones) of drugs-from siRNAs to DNA nanorobots.

    abstract：:Aptamers, nucleic acid ligands that are specific against their corresponding targets are increasingly employed in a variety of applications including diagnostics and therapeutics. The specificity of the aptamers against their targets is also used as the basis for the formulation of the aptamer-based drug delivery syst...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2019.118483

    authors： Citartan M,Kaur H,Presela R,Tang TH

    更新日期：2019-08-15 00:00:00