Arrhenius activation energy of damage to catalase during spray-drying.

Abstract:

:The inactivation of catalase during spray-drying over a range of outlet gas temperatures could be closely represented by the Arrhenius equation. From this an activation energy for damage to the catalase could be calculated. The close fit to Arrhenius suggests that the thermally-induced part of inactivation of the catalase during the complex drying and particle-formation processes takes place at constant temperature. These processes are rapid compared with the residence time of the powder in the collecting vessel of the cyclone where dried catalase is exposed to a constant temperature equal to approximately the drying gas outlet temperature. A lower activation energy after spray drying with the ultrasonic nozzle was found than with the 2-fluid nozzle under otherwise identical spray drying conditions. It is feasible that the ultrasonic nozzle when mounted in the lid of the spray dryer heats up toward the drying gas inlet temperature much more that the air-cooled 2-fluid nozzle. Calculation of the Arrhenius activation energy also showed how the stabilizing efficacy of trehalose and mannitol on the catalase varies in strength across the range of drying gas inlet and outlet temperatures examined.

journal_name

Int J Pharm

authors

Schaefer J,Lee G

doi

10.1016/j.ijpharm.2015.04.078

subject

Has Abstract

pub_date

2015-07-15 00:00:00

pages

124-30

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)00409-3

journal_volume

489

pub_type

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