Abstract：
:The buccal administration of ergotamine tartrate (ET) combined with polyvinyl alcohol (PVA) gel brought about higher plasma concentration of ET compared with that of oral administration of capsules in guinea-pigs. T(max) of ET in plasma of buccal administration was significantly smaller than that of oral administration. For the buccal dosage form of ET, the bioadhesive tablet system (BTS) was newly developed. It consisted of a reservoir of drug and an adhesive region. BTS showed better absorption of ET compared with PVA gel in guinea pigs. Among several pharmaceutical bases in the reservoir of BTS, Witepsol W-35 was most effective. It is likely that the high lipophilic property of Witepsol W-35 in which ET was dissolved facilitated the drug release by its relatively low melting point (around 35 degrees C), consequently a rapid absorption. In addition, the enhancing activity of the cod-liver oil extract (CLOE) in hydrophilic ointment on the in vivo buccal ET absorption was clarified to be comparable to that in the in vitro study utilizing the keratinized epithelial-free membrane (KEF-membrane) of the hamster cheek pouch.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Tsutsumi K,Obata Y,Nagai T,Loftsson T,Takayama Kdoi
10.1016/s0378-5173(02)00070-4keywords:
subject
Has Abstractpub_date
2002-05-15 00:00:00pages
161-70issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517302000704journal_volume
238pub_type
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