当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Mucoadhesive zein/beta-cyclodextrin nanoparticles for the buccal delivery of curcumin.

Mucoadhesive zein/beta-cyclodextrin nanoparticles for the buccal delivery of curcumin.

Abstract：

:Herein, we have developed sprayable dispersions of mucoadhesive nanoparticles (NPs) made of zein, a hydrophobic plant-based protein, for the buccal delivery of curcumin (CUR), a poorly water-soluble polyphenol. NPs were prepared by the liquid-liquid dispersion method using an antisolvent water solution without or with beta-cyclodextrin (CD). NPs were spherical with a monomodal size distribution, a mean size around 140 nm and low polydispersity. Excellent colloidal stability of NPs was found at room temperature for up to 1 month. CUR entrapment was found to depend mainly on the zein/CUR ratio and related to the ability of CUR to set within hydrophobic pockets in the zein matrix. CD addition generated an increase of NP zeta potential up to +60 mV, indicating that positively charged amino acids are prompted to settle on the NP surface. Fluorescence emission spectroscopy indicated that CD interacted with lipophilic amino acids of zein altering interchain interactions and formation of glutamine bridge. Because of zein/CD interactions, mainly occurring at NP periphery, the slowing down of the CUR release rate was observed too. A combination of spectroscopic techniques unequivocally showed that zein NPs strongly interacted with mucin due to electrostatic interactions. Once sprayed on a porcine buccal mucosa, zein/CD NPs securely attached to the tissue resisting repeated washing steps but did not allow CUR transmucosal permeation. Overall, these results point at zein/CD NPs as a novel mucoadhesive platform for the buccal delivery of poorly water-soluble molecules to use as both a food supplement or a drug product to achieve local effects.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Esposito D,Conte C,d'Angelo I,Miro A,Ungaro F,Quaglia F

doi

10.1016/j.ijpharm.2020.119587

subject

Has Abstract

pub_date

2020-08-30 00:00:00

pages

119587

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(20)30571-8

journal_volume

586

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate.

    abstract：:D-glucosamine and chitosan were modified by the immobilization of thiol groups utilizing 2-iminothiolane. The toxicity profile of the resulting D-glucosamine-TBA (4-thiobutylamidine) conjugate, of chitosan-TBA conjugate and of the corresponding unmodified controls was evaluated in vitro. On the one hand, the cell memb...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.03.016

    authors： Guggi D,Langoth N,Hoffer MH,Wirth M,Bernkop-Schnürch A

    更新日期：2004-07-08 00:00:00

  • Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.

    abstract：:Nanoparticles delivery of oligonucleotides represents a potential approach for cancer treatment. However, most of the experiments were based on established cancer cell lines and may not reflect the original solid tumor in vivo. Both, tumor microenvironment and tumor cell biological properties in the tumor can influenc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.07.009

    authors： Dong M,Philippi C,Loretz B,Nafee N,Schaefer UF,Friedel G,Ammon-Treiber S,Griese EU,Lehr CM,Klotz U,Mürdter TE

    更新日期：2011-10-31 00:00:00

  • Mechanical testing methods for drug-releasing vaginal rings.

    abstract：:Vaginal rings (VRs) are currently marketed for contraceptive or hormone regulation purposes, and investigationally, have been widely reported for delivery of antiretrovirals to reduce HIV transmission. To date, there is no national or international standard for the mechanical testing and minimum performance characteri...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.026

    authors： McCoy CF,Millar BG,Murphy DJ,Blanda W,Hansraj B,Devlin B,Malcolm RK,Boyd P

    更新日期：2019-03-25 00:00:00

  • Approaches to determine the enthalpy of crystallisation, and amorphous content, of lactose from isothermal calorimetric data.

    abstract：:Amorphous lactose will crystallise rapidly if its glass transition temperature is reduced below its storage temperature. This is readily achieved by storing samples at ambient temperature and a relative humidity (RH) of greater than 50%. If the sample is monitored in an isothermal microcalorimeter as it crystallises, ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.07.016

    authors： Dilworth SE,Buckton G,Gaisford S,Ramos R

    更新日期：2004-10-13 00:00:00

  • Combining ibuprofen sodium with cellulosic polymers: a deep dive into mechanisms of prolonged supersaturation.

    abstract：:The combination of a highly soluble salt form of a drug with a polymeric precipitation inhibitor has the potential to prolong drug supersaturation even following salt disproportionation. In this study, dissolution profiles of ibuprofen sodium in the presence of various cellulosic polymers, including hydroxypropyl meth...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.09.015

    authors： Terebetski JL,Michniak-Kohn B

    更新日期：2014-11-20 00:00:00

  • Nanosuspension for improving the bioavailability of a poorly soluble drug and screening of stabilizing agents to inhibit crystal growth.

    abstract：:The purpose of this study was to develop a nanosuspension of a poorly soluble drug by nanomilling process using wet media milling to achieve superior in vitro dissolution and high in vivo exposure in pharmacokinetic studies. A promising nanosuspension was developed with Vitamin E TPGS based formulation with particle s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.051

    authors： Ghosh I,Bose S,Vippagunta R,Harmon F

    更新日期：2011-05-16 00:00:00

  • Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes: Evaluation of suitable plasticizers.

    abstract：:The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes. Specifically, the effect of mannitol (MAN), sorbitol (SOR), sucrose (SUC), anh...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119121

    authors： Katopodis K,Kapourani A,Vardaka E,Karagianni A,Chorianopoulou C,Kontogiannopoulos KN,Bikiaris DN,Kachrimanis K,Barmpalexis P

    更新日期：2020-03-30 00:00:00

  • A novel formulation of solubilised amphotericin B designed for ophthalmic use.

    abstract：:Amphotericin B (AmB) is a wide spectrum antifungal with low incidence of clinical resistance. However, there are no licensed topical formulations with AmB in most developed countries. Extemporaneous preparations of AmB are frequently prepared from available marketed parenteral formulations. Herein, a solution of AmB w...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.065

    authors： Serrano DR,Ruiz-Saldaña HK,Molero G,Ballesteros MP,Torrado JJ

    更新日期：2012-11-01 00:00:00

  • Development and evaluation of a dimensionless mechanistic pan coating model for the prediction of coated tablet appearance.

    abstract：:A mathematical, mechanistic tablet film-coating model has been developed for pharmaceutical pan coating systems based on the mechanisms of atomisation, tablet bed movement and droplet drying with the main purpose of predicting tablet appearance quality. Two dimensionless quantities were used to characterise the produc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.05.060

    authors： Niblett D,Porter S,Reynolds G,Morgan T,Greenamoyer J,Hach R,Sido S,Karan K,Gabbott I

    更新日期：2017-08-07 00:00:00

  • Development of a lyophilized kit formulation for labeling of DNA probes with 99mTc.

    abstract：:DNA fragments such as oligodeoxynucleotides (ODNs) are under investigation for a possible utilization in nuclear medicine. Until now, experiments on 99mTc-labeled ODNs in vitro or in vivo have required the application of time-consuming procedures to obtain and control the purity of the radiolabeled compound. A lyophil...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00293-8

    authors： Hjelstuen OK,Saetern AM,Tonnesen HH,Bremer PO,Verbruggen AM

    更新日期：1999-11-15 00:00:00

  • Effect of medium-chain triglycerides on the release behavior of Endostar encapsulated PLGA microspheres.

    abstract：:The incomplete release of Endostar from PLGA microspheres was observed in our previous study. In the present study, we focused on the effect of medium-chain triglycerides (MCT) on the in vitro/in vivo release behavior of Endostar encapsulated PLGA microspheres, which were prepared by a water-in-oil-in-water (W/O/W) do...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.07.018

    authors： Meng B,Li L,Hua S,Wang Q,Liu C,Xu X,Yin X

    更新日期：2010-09-15 00:00:00

  • Protein aggregation--pathways and influencing factors.

    abstract：:Proteins generally will tend to aggregate under a variety of environmental conditions in comparison with small drug molecules. The extent of aggregation is dependent on many factors that can be broadly classified as intrinsic (primary, secondary, tertiary or quaternary structure) or extrinsic (environment in which pro...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2010.02.025

    authors： Wang W,Nema S,Teagarden D

    更新日期：2010-05-10 00:00:00

  • Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance.

    abstract：:This study aims to investigate the effect of carrier characteristics and dosator capsule filling operation on the in vitro deposition of mixtures containing salbutamol sulphate (SS) and lactose and mannitol as model carrier materials. The carrier surfaces of lactose and mannitol were modified via wet decantation. The ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.06.044

    authors： Faulhammer E,Wahl V,Zellnitz S,Khinast JG,Paudel A

    更新日期：2015-08-01 00:00:00

  • Enhanced glioma therapy by synergistic inhibition of autophagy and tyrosine kinase activity.

    abstract：:Autophagy is a lysosomal degradation pathway that acts as a cytoprotective mechanism causing treatment resistance in various cancer cells. Recent studies showed that hydroxychloroquine can inhibit the latter step of autophagy and therefore enhance the anti-glioma efficiency of ZD6474, a tyrosine kinase inhibitor. Howe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.09.007

    authors： Wang X,Qiu Y,Yu Q,Li H,Chen X,Li M,Long Y,Liu Y,Lu L,Tang J,Zhang Z,He Q

    更新日期：2018-01-30 00:00:00

  • Emerging trends in the stabilization of amorphous drugs.

    abstract：:The number of active pharmaceutical substances having high therapeutic potential but low water solubility is constantly increasing, making it difficult to formulate these compounds as oral dosage forms. The solubility and dissolution rate, and thus potentially the bioavailability, of these poorly water-soluble drugs c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2012.04.066

    authors： Laitinen R,Löbmann K,Strachan CJ,Grohganz H,Rades T

    更新日期：2013-08-30 00:00:00

  • Powder, capsule and device: An imperative ménage à trois for respirable dry powders.

    abstract：OBJECTIVES:The development of inhaled products to treat or to prevent lung infection is a very active research field in drug delivery. The pulmonary route is extremely attractive but very challenging. This paper reports the study of excipient, capsule brand and device influence on the aerodynamic behavior of dry powder...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.012

    authors： Schoubben A,Blasi P,Giontella A,Giovagnoli S,Ricci M

    更新日期：2015-10-15 00:00:00

  • Effect of hydroxypropyl cellulose (HPC) on dissolution rate of hydrochlorothiazide tablets.

    abstract：:Hydrochlorothiazide (HCTZ) 60 mg strength tablets containing commonly used excipients and hydroxypropyl cellulose, marketed as either Klucel-EF (HPC, NF from Hercules, USA) or HPC-L (HPC, NF from Nippon Soda, Japan), as a binder were manufactured using identical aqueous wet granulation process. The tablets containing ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.10.011

    authors： Desai D,Rinaldi F,Kothari S,Paruchuri S,Li D,Lai M,Fung S,Both D

    更新日期：2006-02-03 00:00:00

  • Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate.

    abstract：:To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.11.001

    authors： Uchimoto T,Iwao Y,Ikegami Y,Murata T,Sonobe T,Miyagishima A,Itai S

    更新日期：2010-02-15 00:00:00

  • Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride.

    abstract：:The feasibility of a colorimetric technique was investigated in CIELAB color space as an analytical quality control method for content uniformity of printed orodispersible pediatric delivery systems. Inkjet printing was utilized to fabricate orodispersibe film formulations containing propranolol hydrochloride in a col...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.032

    authors： Vakili H,Nyman JO,Genina N,Preis M,Sandler N

    更新日期：2016-09-10 00:00:00

  • Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability.

    abstract：:Lipid-based liquid crystalline nanoparticles (LCNPs) have attracted growing interest as a new drug nanocarrier system for improving bioavailability for both hydrophilic and hydrophobic drugs. In this study, self-assembled LCNPs based on soy phosphatidyl choline and glycerol dioleate, which was known possessing low tox...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.12.058

    authors： Zeng N,Hu Q,Liu Z,Gao X,Hu R,Song Q,Gu G,Xia H,Yao L,Pang Z,Jiang X,Chen J,Fang L

    更新日期：2012-03-15 00:00:00

  • Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system.

    abstract：:In this study, a temperature and ROS-responsive drug delivery system ROSP@MSN based on mesoporous silica nanoparticles has been designed and synthesized by taking advantage of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate modified polymers (ROSP) as "nano-valve", which can respond selectively to cance...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.11.025

    authors： Yu F,Wu H,Tang Y,Xu Y,Qian X,Zhu W

    更新日期：2018-01-30 00:00:00

  • Characterization and monitoring of pseudo-polymorphs in manufacturing process by NIR.

    abstract：:Moisture-sensitive pseudo-polymorphs with different stabilities were characterized, and their polymorphisms were monitored in the process of tableting and film coating by near-infrared (NIR) spectroscopy. In this study, we proved that we could successfully maintain the crystal form ratio in the tablet by controlling t...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.10.010

    authors： Kamada K,Yoshimura S,Murata M,Murata H,Nagai H,Ushio H,Terada K

    更新日期：2009-02-23 00:00:00

  • A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study.

    abstract：:The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implanted v. jugularis ext. into a. carotis communis in rabbits. The vein ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.02.023

    authors： Skalský I,Szárszoi O,Filová E,Pařízek M,Lytvynets A,Malušková J,Lodererová A,Brynda E,Lisá V,Burdíková Z,Capek M,Pirk J,Bačáková L

    更新日期：2012-05-10 00:00:00

  • Drug release modeled by dissolution, diffusion, and immobilization.

    abstract：:This article presents a novel drug release model that combines drug dissolution, diffusion, and immobilization caused by adsorption of the drug to the tablet constituents. Drug dissolution is described by the well-known Noyes-Whitney equation and drug adsorption by a Langmuir-Freundlich adsorption isotherm, and these ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00539-2

    authors： Frenning G,Strømme M

    更新日期：2003-01-02 00:00:00

  • Elastic-plastic contact law for simulation of tablet crushing using the biharmonic equation.

    abstract：:This work presents a technique for shape modelling of cylindrical and spherical tablets subject to compression. This technique is based on the use of partial differential equations (PDEs), the biharmonic equation in particular. The deformation of the compressed elastic-plastic tablet of both shapes was obtained using ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.01.053

    authors： Ahmat N,Ugail H,González Castro G

    更新日期：2012-05-10 00:00:00

  • Effect of camphor/cyclodextrin complexation on the stability of O/W/O multiple emulsions.

    abstract：:Camphor (CA) encapsulation in oil/water/oil multiple emulsions prepared with cyclodextrin disturbs the emulsifier potential of alpha- and beta-natural cyclodextrins (CD). It was suggested that the size and geometrical fit between the CD cavity and CA could induce CD/CA complex formation in place of emulsifier formatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00261-8

    authors： Yu SC,Bochot A,Bas GL,Chéron M,Mahuteau J,Grossiord JL,Seiller M,Duchêne D

    更新日期：2003-08-11 00:00:00

  • Niosomes and discomes for ocular delivery of naltrexone hydrochloride: morphological, rheological, spreading properties and photo-protective effects.

    abstract：:Naltrexone hydrochloride (NTX) is a promising treatment for corneal disorders linked to diabetes mellitus (diabetic keratopathy). However, NTX has a major stability problem due to autoxidation, which is likely to hinder its formulation as eye drops for treatment of diabetic keratopathy. In this study, in-house develop...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.05.011

    authors： Abdelkader H,Wu Z,Al-Kassas R,Alany RG

    更新日期：2012-08-20 00:00:00

  • Effect of alkylcarbonates of gamma-cyclodextrins with different chain lengths on drug complexation and release characteristics.

    abstract：:Alkylcarbonates of gamma-cyclodextrins were produced and their inclusion complexes with four poorly water-soluble drugs of different structures and solubilities were prepared. The alkylcarbonates and the alkylcarbonate drug complexes were characterized by DSC and XRPD; the physical mixtures were used as control. Solub...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.03.001

    authors： Cavalli R,Trotta F,Trotta M,Pastero L,Aquilano D

    更新日期：2007-07-18 00:00:00

  • Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.

    abstract：:Electrospun composite zein/eudragit nanofibers were developed with an aim to deliver two different classes of drugs simultaneously that would restrict/compensate the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs). Co-administration of proton pump inhibitors is beneficial for patients consuming NSAID...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.075

    authors： Karthikeyan K,Guhathakarta S,Rajaram R,Korrapati PS

    更新日期：2012-11-15 00:00:00

  • Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain.

    abstract：:The aim of this study was to investigate the influence of the proteolytic enzyme bromelain on the permeation of heparin across the gastrointestinal epithelial barrier. Stability of the complex and effect of heparin on the enzymatic activity of bromelain was analysed photometrically by measuring bromelain enzymatic act...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.06.042

    authors： Grabovac V,Bernkop-Schnürch A

    更新日期：2006-12-01 00:00:00