Abstract：
:Many fabrication methods for microneedle (MN) involve harsh conditions and long drying time. This study aims to fabricate a dissolving MN patch in a simple and efficient manner under mild conditions, using a combination of thermal and photo polymerisation. The MN patch was fabricated by pre-polymerisation of vinylpyrrolidone solution with heating followed by photolithography. The heating temperature and time of pre-polymer solution curing were optimized based on viscosity measurement. The MN properties including shape, size, skin penetration, dissolution, moisture absorption were determined. The fabricated MNs were sharp and consistent. The heated N-vinylpyrrolidone solution required less UV exposure time, thus reducing the total fabrication time. The percentage of MN penetration in human cadaver skin was more than 33.9%. The MN was dissolved within 1-2 min in water, or 40 min in saturated water vapor.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Kathuria H,Kang K,Cai J,Kang Ldoi
10.1016/j.ijpharm.2019.118992subject
Has Abstractpub_date
2020-02-15 00:00:00pages
118992eissn
0378-5173issn
1873-3476pii
S0378-5173(19)31053-1journal_volume
575pub_type
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