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A novel remote controlled capsule for site-specific drug delivery in human GI tract.

Abstract：

:Remote controlled capsule (RCC) has been extensively used in the field of site-specific drug delivery. It is a potent tool to study the regional drug absorption of the gastrointestinal (GI) tract that provides pharmaceutical scientists with significant pharmacokinetics data for oral drug formulation development. In present investigations, a patented novel RCC has been devised based on micro-electronic mechanical system (MEMS) technology. Micro-thrusters were for the first time exploited as drug release actuators of RCCs. As the micro-thruster is ignited by a radio frequency (RF) signal, the thrust force generated by the propellants pushes the piston forward and leads to a rapid and complete expulsion of therapeutic agents from the capsule. The micro-thruster merely consumes 120 mW for ignition and the duration time of drug release is decreased to less than 1 s. The feasibility of the novel RCC was evaluated through animal experiments in beagles using aminophylline as the model drug. The novel RCC developed is a promising alternative for site-specific drug delivery in human GI tract.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Xitian P,Hongying L,Kang W,Yulin L,Xiaolin Z,Zhiyu W

doi

10.1016/j.ijpharm.2009.08.026

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

160-4

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(09)00574-2

journal_volume

382

pub_type

杂志文章

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