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Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.

Abstract：

:Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40 degrees C. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Souto EB,Wissing SA,Barbosa CM,Müller RH

doi

10.1016/j.ijpharm.2004.02.032

keywords:

subject

Has Abstract

pub_date

2004-06-18 00:00:00

pages

71-7

issue

1

eissn

0378-5173

issn

1873-3476

pii

S037851730400153X

journal_volume

278

pub_type

杂志文章

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