Abstract：
:Two different PLGA samples (Resomer 502 and Resomer 506), either alone or in combinations, were used to prepare microcapsules. Microcapsules were prepared using a double emulsion solvent evaporation technique. The efficiency of encapsulation increased significantly when a mixture of 1 part Resomer 506 and 7 parts Resomer 502 was used to prepare the microcapsules. The efficiency of encapsulation of this batch was 23.7%, whereas the efficiency of encapsulations was only 13.9 and 9.8%, respectively, when the microcapsules were prepared with 100% Resomer 502 or 100% Resomer 506. In contrast, irrespective of the relative ratio of Resomer 502/Resomer 506, the median particle size of the microcapsules showed similar distribution pattern with the median size lies between 49 and 83microm. The glass transition temperature (T(g)) decreased significantly (44.6-25.5 degrees C) as the amount of Resomer 502 was increased in the formulation. The presence of Resomer 502 at lower concentration, along with Resomer 506, initially reduced the "burst effect." However, incorporation of a higher amount of Resomer 502 increased the "burst effect." Drug release from these microcapsules continued over 80 days. In conclusion, efficiency of encapsulation increased significantly when Resomer 506 was mixed with Resomer 502 at a ratio of 1:7. Blending of Resomer 502 with Resomer 506 reduced the glass transition temperature, which resulted in higher amount of drug release throughout the dissolution study.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Graves RA,Pamujula S,Moiseyev R,Freeman T,Bostanian LA,Mandal TKdoi
10.1016/j.ijpharm.2003.10.019keywords:
subject
Has Abstractpub_date
2004-02-11 00:00:00pages
251-62issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517303005775journal_volume
270pub_type
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