Abstract：
:The tack of a pressure sensitive adhesive (PSA) is not an inherent material property and strongly depends on the measurement conditions. Following the concept of a measurement system analysis (MSA), influencing factors of the probe tack test were investigated by a design of experiments (DoE) approach. A response surface design with 38 runs was built to evaluate the influence of detachment speed, dwell time, contact force, adhesive film thickness and API content on tack, determined as the maximum of the stress strain curve (σmax). It could be shown that all investigated factors have a significant effect on the response and that the DoE approach allowed to detect two-factorial interactions between the dwell time, the contact force, the adhesive film thickness and the API content. Surprisingly, it was found that tack increases with decreasing and not with increasing adhesive film thickness.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Michaelis M,Leopold CSdoi
10.1016/j.ijpharm.2015.09.061subject
Has Abstractpub_date
2015-12-30 00:00:00pages
448-56issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30259-3journal_volume
496pub_type
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