Abstract：
:The study deals with the intercalation of procainamide hydrochloride (PA), an antiarrythmia drug in montmorillonite (MMT), as a new drug delivery device. Optimum intercalation of PA molecules within the interlayer space of MMT was achieved by means of different reaction conditions. Intercalation of PA in the MMT galleries was conformed by X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), and thermal analysis (DSC). In order to retard the quantity of drug release in the gastric environment, the prepared PA-MMT composite was compounded with alginate (AL), and further coated with chitosan (CS). The surface morphology of the PA-MMT-AL and PA-MMT-AL-CS nanocomposites beads was analyzed by scanning electron microscope (SEM). The in vitro release experiments revealed that AL and CS were able to retard the drug release in gastric environments, and release the drug in the intestinal environments with a controlled manner. The release profiles of PA from composites were best fitted in Higuchi kinetic model, and Korsmeyer-Peppas model suggested diffusion controlled release mechanism.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Kevadiya BD,Joshi GV,Bajaj HCdoi
10.1016/j.ijpharm.2010.01.002subject
Has Abstractpub_date
2010-03-30 00:00:00pages
280-6issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(10)00016-5journal_volume
388pub_type
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