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Effect of granule properties on rough mouth feel and palatability of orally disintegrating tablets.

Abstract：

:In this study, we evaluated the palatability of orally disintegrating tablets (ODTs) containing core granules with different particle sizes, coating, and types of materials using visual analog scales (VAS). Tableting the core granules into ODTs reduced rough mouth feel and improved overall palatability compared to the ingestion of core granules alone. Moreover, the evaluation performed immediately after spitting out ODTs demonstrated differences in rough mouth feel between ODTs containing placebo and core granules. Rough mouth feel was found to be significantly more intense with core granules with particle sizes ≥ 200 μm. Since ODTs may contain taste-masked particles, palatability of ODTs containing coated core granules was also evaluated. Although coating with polymers impairs palatability, it was improved by coating the outer layer with d-mannitol. The effects on palatability of materials constituting core granules were also evaluated, with reduced rough mouth feel observed with core granules composed of water-soluble additives. Based on these data, receiver operating characteristic analysis was performed to determine the threshold VAS scores at which the subjects felt roughness and discomfort. In addition, the threshold particle size of the core granule contained within the ODT required for feeling roughness was determined to be 244 μm. This study elucidated the effect of the properties of masking particles on the rough mouth feel and palatability of ODTs.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Kimura S,Uchida S,Kanada K,Namiki N

doi

10.1016/j.ijpharm.2015.02.023

subject

Has Abstract

pub_date

2015-04-30 00:00:00

pages

156-62

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)00119-2

journal_volume

484

pub_type

杂志文章,随机对照试验

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