当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Evaluation of a cationic calix[4]arene: Solubilization and self-aggregation ability.

Evaluation of a cationic calix[4]arene: Solubilization and self-aggregation ability.

Abstract：

:Water-soluble calixarenes are promising macrocyclic compounds which have found numerous applications in chemistry and biology. However, these compounds have been less studied in regard to their behavior in aqueous solutions and mechanisms of drug solubilization. The present work is devoted to the evaluation of the solubilizing properties and estimation of self-aggregation ability of positively charged 5,11,17,23-tetrakis(trimethylammoniomethyl)-25,26,27,28-tetrapropoxy-calix[4]arene tetrachloride (aminocalix), including comparisons with a series of pharmaceutically relevant cyclodextrins. Phase-solubility measurements of the drugs with aminocalix and various cyclodextrins were carried out. Aminocalix showed a solubilizing ability comparable to the cyclodextrins. The drug solubility enhancement caused by the aminocalix was studied and was found to be maximal for steroid drugs. An attempt to understand the solubilizing mechanism of aminocalix was undertaken based on correlation analysis between physical and physico-chemical properties of the drugs from one side and the solubilizing ability of aminocalix from the other. Correlation analysis supports the supposition that the solubilizing effect of aminocalix is based on interaction of the drug with aminocalix aggregates rather than on inclusion complexation. UV-absorbance, osmolality and surface tension concentration dependences of aminocalix showed an inflection at 1% (w/v) which was initially related to the transition from monomers to micelles. However, dynamic light scattering and transmission electron microscopy measurements revealed that likely vesicles of diverse size exist at 0.1% (w/v) concentration. Thus the 1% (w/v) inflection point was interpreted to be spontaneous reordering of the vesicles between two different size populations.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Ukhatskaya EV,Kurkov SV,Matthews SE,El Fagui A,Amiel C,Dalmas F,Loftsson T

doi

10.1016/j.ijpharm.2010.09.011

subject

Has Abstract

pub_date

2010-12-15 00:00:00

pages

10-9

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(10)00712-X

journal_volume

402

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Glutathione-responsive self-delivery nanoparticles assembled by curcumin dimer for enhanced intracellular drug delivery.

    abstract：:Poor water solubility, short half-life, and low drug efficacy posed a challenge for clinical application of curcumin (CUR). In this work, a kind of CUR prodrug was synthesized by coupling two CUR molecules with a mono-thioether linker for glutathione (GSH)-responsive drug delivery. The synthesized CUR prodrug (CUR-S-C...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.07.061

    authors： Zhang H,Zhang Y,Chen Y,Zhang Y,Wang Y,Zhang Y,Song L,Jiang B,Su G,Li Y,Hou Z

    更新日期：2018-10-05 00:00:00

  • Quantifying electrostatic interactions in pharmaceutical solid systems.

    abstract：:Triboelectrification of pharmaceutical powders with stainless steel and polymer contact surfaces was investigated. alpha-Lactose monohydrate, from 90 to 125 up to 355-500 microm, was used to quantify electrostatic interactions with negligible powder adhesion to the contact surface. Size fractions down to 53-75 microm ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00784-0

    authors： Rowley G

    更新日期：2001-10-04 00:00:00

  • Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock.

    abstract：:d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models. The original BHB/MLT formulation contains dimethyl sulfoxide (DMSO) to increase melatonin solubility. We formulated BHB/MLT solutions wherein DMSO was replaced either with 10% polyvinylpyrrolidone (BHB/MLT/PVP) or with ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.046

    authors： Wolf A,Thakral S,Mulier KE,Suryanarayanan R,Beilman GJ

    更新日期：2018-09-05 00:00:00

  • Double barrier as an effective method for slower delivery rate of ibuprofen.

    abstract：:Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-lo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.06.037

    authors： Kurczewska J,Lewandowski D,Olejnik A,Schroeder G,Nowak I

    更新日期：2014-09-10 00:00:00

  • Effects of molecular weight of polyvinylpyrrolidone on the glass transition and crystallization of co-lyophilized sucrose.

    abstract：:The purpose of the present study was to investigate the effects of molecular weight (MW) of polyvinylpyrrolidone (PVP) on glass transition and crystallization of sucrose. Thus, sucrose was co-lyophilized with 2.5 and 5.0% w/w PVP of different molecular weights, which were characterized using gel permeation chromatogra...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00613-5

    authors： Zeng XM,Martin GP,Marriott C

    更新日期：2001-05-07 00:00:00

  • Dehydration behavior of nedocromil magnesium pentahydrate.

    abstract：:The dehydration of nedocromil magnesium (NM) pentahydrate proceeds in two steps, corresponding to the loss of four water molecules in the first step and one water molecule in the second step. The effects of temperature, particle size, sample weight, water vapor pressure and dehydration-rehydration cycle on both the ki...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00700-6

    authors： Zhu H,Grant DJ

    更新日期：2001-03-14 00:00:00

  • Synthesis and characterization of hydrogels formed from a glycidyl methacrylate derivative of galactomannan.

    abstract：:The present investigation describes a procedure for the synthesis of a glycidyl methacrylated derivative from galactomannan, GA-MA, and the respective hydrogel formation. The galactomannan (GA), raw material, was purified and dissolved in DMSO. After dissolution, 4-dimethyl-amino-pyridine (DMAP) and glycidyl methacryl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.08.001

    authors： Reis AV,Cavalcanti OA,Rubira AF,Muniz EC

    更新日期：2003-11-28 00:00:00

  • The dispersion behaviour of dry powder inhalation formulations cannot be assessed at a single inhalation flow rate.

    abstract：:The dispersion performances of inhalation powders are often tested at only one inhalation flow rate in mechanistic formulation studies. This limited approach is challenged by studies showing that interactions exist between inhalation flow rate and the effects on dispersion performance of several formulation variables....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.024

    authors： Grasmeijer F,de Boer AH

    更新日期：2014-04-25 00:00:00

  • Pharmacokinetic study of a carbamazepine nanoemulsion in beagle dogs.

    abstract：:This work describes the pharmacokinetics of a novel carbamazepine nanoemulsion. The plasma concentration profiles were determined in beagle dogs after i.v. bolus administration of a 5 mg/kg carbamazepine nanoemulsion and compared to the corresponding carbamazepine/hydroxypropyl-beta-cyclodextrin complex solution. Both...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.05.055

    authors： Kuminek G,Kratz JM,Ribeiro R,Kelmann RG,de Araújo BV,Teixeira HF,Simões CM,Koester LS

    更新日期：2009-08-13 00:00:00

  • Edetate calcium disodium nanoparticle dry powder inhalation: a novel approach against heavy metal decorporation.

    abstract：:Objective was to develop and characterize nano-edetate calcium disodium (Ca-Na(2)EDTA) dry powder inhaler (DPI), and assess its in vitro and in vivo deposition using pharmacoscintigraphy techniques. Factors influencing nanoparticle formation including concentration of drug, polymer solution and stirring rate were dete...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijpharm.2011.06.038

    authors： Kumar N,Soni S,Jaimini A,Ahmad FJ,Bhatnagar A,Mittal G

    更新日期：2011-09-15 00:00:00

  • Formulation design and evaluation of amorphous ABT-102 nanoparticles.

    abstract：:Amorphous nanoparticles are able to enhance the kinetic solubility and concomitant dissolution rates of BCS class II and BCS class II/IV molecules due to their characteristic increased supersaturation levels, smaller particle size and greater surface area. A DoE approach was applied to investigate formulation and spra...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.12.033

    authors： Jog R,Kumar S,Shen J,Jugade N,Tan DC,Gokhale R,Burgess DJ

    更新日期：2016-02-10 00:00:00

  • Doxorubicin liposomes cell penetration enhancement and its potential drawbacks for the tumor targeting efficiency.

    abstract：:The clinical efficacy of the PEGylated doxorubicin liposomes (PLD) is limited by low tumor accumulation and limited intra-tumoral disposition. Decoration with the cell penetration enhancers (CPEs) can increase the PLD permeability via the biological barriers, however at the expense of enhanced distribution to the non-...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.120012

    authors： Popilski H,Feinshtein V,Kleiman S,Mattarei A,Garofalo M,Salmaso S,Stepensky D

    更新日期：2021-01-05 00:00:00

  • Nasal timosaponin BII dually sensitive in situ hydrogels for the prevention of Alzheimer's disease induced by lipopolysaccharides.

    abstract：:Alzheimer's disease (AD) is a common and severe brain disease with a high mortality among the elders, but no highly efficient medications are currently available. For example, timosaponin BII, an efficient anti-AD agent, has low oral bioavailability. Here, timosaponin BII was formulated in a temperature/ion-sensitive ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119115

    authors： Chen W,Li R,Zhu S,Ma J,Pang L,Ma B,Du L,Jin Y

    更新日期：2020-03-30 00:00:00

  • Characterization of inhalation aerosols: a critical evaluation of cascade impactor analysis and laser diffraction technique.

    abstract：:Cascade impactor analysis is the standard technique for in vitro characterization of aerosol clouds generated by medical aerosol generators. One important reason for using this inertial separation principle is that drug fractions are classified into aerodynamic size ranges that are relevant to the deposition in the re...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00526-4

    authors： de Boer AH,Gjaltema D,Hagedoorn P,Frijlink HW

    更新日期：2002-12-05 00:00:00

  • Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part II - Solid-in-Oil dispersion of nanoparticulate benzoyl peroxide.

    abstract：:Benzoyl peroxide as a monotherapeutic and in combination with adapalene is a cornerstone of current acne therapy, but its unfavourable side effect profile reduces the therapeutic value of this compound. The incorporation into an adapalene-loaded microparticulate lipid matrix, which - via the principle of targeted eros...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118792

    authors： Brammann C,Müller-Goymann CC

    更新日期：2019-12-15 00:00:00

  • Preparation and characterization of teniposide PLGA nanoparticles and their uptake in human glioblastoma U87MG cells.

    abstract：:Many studies have demonstrated the uptake mechanisms of various nanoparticle delivery systems with different physicochemical properties in different cells. In this study, we report for the first time the preparation and characterization of teniposide (VM-26) poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) an...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.050

    authors： Mo L,Hou L,Guo D,Xiao X,Mao P,Yang X

    更新日期：2012-10-15 00:00:00

  • Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells.

    abstract：:In this study, solid lipid nanoparticles (SLN) loaded with MBO-asGCS oligonucleotide were prepared, characterized and evaluated for cytotoxicity against NCI/ADR-RES human ovary cancer cells. Two types of cetyltrimethyl ammonium bromide (CTAB) stabilized SLN, with or without ceramide VI, were prepared by mixed homogeni...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.08.044

    authors： Siddiqui A,Patwardhan GA,Liu YY,Nazzal S

    更新日期：2010-11-15 00:00:00

  • Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery.

    abstract：:Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the literature on an important subcategory of emulsions, microemulsions. Microemulsions are optically transparent, thermodynamically stable colloidal systems, 10-100nm diameter, that form s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.05.005

    authors： Callender SP,Mathews JA,Kobernyk K,Wettig SD

    更新日期：2017-06-30 00:00:00

  • Amino Acid-functionalized hollow mesoporous silica nanospheres as efficient biocompatible drug carriers for anticancer applications.

    abstract：:Herein, a series of new amino acid-functionalized hollow mesoporous silica nanospheres (HMSNs) by post-grafting methods were prepared. These new materials were characterized by different techniques and were studied as matrices for the antineoplastic drug (cisplatin) transport and delivery. The results demonstrate that...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118709

    authors： Ezzati N,Mahjoub AR,Abolhosseini Shahrnoy A,Syrgiannis Z

    更新日期：2019-12-15 00:00:00

  • Practical approach to prepare solid dispersion drug product using spherical silicate.

    abstract：:The purpose of this study is to establish a novel approach for preparing a solid dispersion drug product using spherical silicate by a Wurster-type fluidized bed granulator. The spherical silicate used in this study has porous structure and ideal particle size for loading by a Wurster-type fluidized bed granulator. As...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.016

    authors： Nagane K,Kimura S,Ukai K,Ogawa N,Yamamoto H

    更新日期：2014-11-20 00:00:00

  • Prolonged subcutaneous delivery of low molecular weight heparin based on thermoresponsive hydrogels with chitosan nanocomplexes: Design, in vitro evaluation, and cytotoxicity studies.

    abstract：:Low molecular weight heparins (LMWHs) have risen in popularity over the past decades. Owing to their appropriate pharmacokinetic profile, they enable long-term clinical applications, e.g. prophylaxis of deep vein thrombosis. Although the administration of LMWHs is not as frequent as of heparin, it still requires once ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.04.063

    authors： Radivojša Matanović M,Grabnar I,Gosenca M,Grabnar PA

    更新日期：2015-07-05 00:00:00

  • Macromolecular prodrugs: X. Kinetics of fenoprofen release from PHEA-fenoprofen conjugate.

    abstract：:The kinetics of fenoprofen release from poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-fenoprofen conjugate (PHEA-Fen) in aqueous buffer solutions (pH 10 and 1.1), simulated gastric (SGF) and intestinal fluids (SIF) was studied. In borate buffer pH 10, the following rate constants were obtained: k=0.2659 (t=60 deg...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00197-7

    authors： van der Merwe T,Boneschans B,Zorc B,Breytenbach J,Zovko M

    更新日期：2002-07-25 00:00:00

  • Formulation parameters governing sustained protein delivery from degradable viscous liquid aliphatic polycarbonates.

    abstract：:Viscous liquid degradable polymers have advantages as drug depots for sustained protein delivery. We have created a new aliphatic polycarbonate for this purpose, poly(trimethylene carbonate-co-5-hydroxy trimethylene carbonate), which upon degradation retains a near neutral micro-environmental pH. As such, this copolym...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119965

    authors： Mohajeri S,Burke-Kleinman J,Maurice DH,Amsden BG

    更新日期：2020-11-30 00:00:00

  • Controlled release of linear-dendritic hybrids of carbosiloxane dendrimer: the effect of hybrid's amphiphilicity on drug-incorporation; hybrid-drug interactions and hydrolytic behavior of nanocarriers.

    abstract：:Dendritic micelles formed from amphiphilic dendritic ABA triblock copolymers based on organic linear poly(ethylene oxide) and inorganic dendritic block containing silicon atoms (OSC-D(Gn)-PEO-D(Gn)-CSO, n=1-3)(1) were evaluated as drug delivery vehicles for a drug in both lipophilic and hydrophilic forms. The physical...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.01.007

    authors： Namazi H,Jafarirad S

    更新日期：2011-04-04 00:00:00

  • Quaternary polymethacrylate-magnesium aluminum silicate films: molecular interactions, mechanical properties and tackiness.

    abstract：:The aim of this study was to investigate the impact of the addition of magnesium aluminum silicate (MAS), a natural clay, on the properties of polymeric films based on quaternary polymethacrylates (QPMs). Two commercially available aqueous QPM dispersions were studied: Eudragit(®) RS 30D and Eudragit(®) RL 30D (the dr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.10.016

    authors： Rongthong T,Sungthongjeen S,Siepmann J,Pongjanyakul T

    更新日期：2013-12-15 00:00:00

  • A novel remote controlled capsule for site-specific drug delivery in human GI tract.

    abstract：:Remote controlled capsule (RCC) has been extensively used in the field of site-specific drug delivery. It is a potent tool to study the regional drug absorption of the gastrointestinal (GI) tract that provides pharmaceutical scientists with significant pharmacokinetics data for oral drug formulation development. In pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.08.026

    authors： Xitian P,Hongying L,Kang W,Yulin L,Xiaolin Z,Zhiyu W

    更新日期：2009-12-01 00:00:00

  • Dual-responsive lidocaine in situ gel reduces pain of intrauterine device insertion.

    abstract：:The most effective and safe contraceptive method, intrauterine devices (IUDs), is still underutilized due to the pain barrier during IUD insertion. Lidocaine, a well-known local anesthetic, can be used to relieve IUD insertion pain. This study aimed at formulation, in vitro, in vivo and clinical evaluation of a novel ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2018.01.033

    authors： Abd Ellah NH,Abouelmagd SA,Abbas AM,Shaaban OM,Hassanein KMA

    更新日期：2018-03-01 00:00:00

  • Localized drug delivery with mono and bilayered mucoadhesive films and wafers for oral mucosal infections.

    abstract：:Local drug delivery into oral cavity offers many advantages over systemic administration in treatment of the oral infections. In this study, monolayer and bilayered mucoadhesive film and wafer formulations were developed as local drug delivery platforms using chitosan and hydroxypropyl methylcellulose (HPMC). Cefuroxi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.029

    authors： Timur SS,Yüksel S,Akca G,Şenel S

    更新日期：2019-03-25 00:00:00

  • Sterilization of implantable polymer-based medical devices: A review.

    abstract：:This review article is focused on the sterilization techniques used for polymer-based implantable medical devices as well as the regulatory aspects governing sterile medical devices. Polymeric materials are increasingly used in implantable devices due to their biodegradable and biocompatible nature. Patients and medic...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.12.003

    authors： Tipnis NP,Burgess DJ

    更新日期：2018-06-15 00:00:00

  • NaCl strongly modifies the physicochemical properties of aluminum hydroxide vaccine adjuvants.

    abstract：:The immunostimulation capacity of most vaccines is enhanced through antigen adsorption on aluminum hydroxide (AH) adjuvants. Varying the adsorption conditions, i.e. pH and ionic strength (I), changes the antigen adsorbed amount and therefore the ability of the vaccine to stimulate the immune system. Vaccine formulatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.12.019

    authors： Art JF,Vander Straeten A,Dupont-Gillain CC

    更新日期：2017-01-30 00:00:00