Abstract：
:Dendritic micelles formed from amphiphilic dendritic ABA triblock copolymers based on organic linear poly(ethylene oxide) and inorganic dendritic block containing silicon atoms (OSC-D(Gn)-PEO-D(Gn)-CSO, n=1-3)(1) were evaluated as drug delivery vehicles for a drug in both lipophilic and hydrophilic forms. The physical parameters of the drug-incorporated carriers including the influences of drug:carrier ratio, the release kinetics of the drugs from the micellar solution were measured. The apparent partition constant of drug between the carriers and the external medium was studied as well. It was observed that the loading efficiency and hydrolytic behavior of the hybrids depend on several factors, such as type of interaction between host and guest molecules, generation of the dendritic copolymers and pH. The release profiles of the drugs from the micelle solution were found to be a slow steady release at pH 1, 7.4 and 10. Investigation of the drug release dynamics in buffered media at pH 7.4 showed that the drug released through the carriers with slight deviation follow Fickian and Case II diffusion mechanisms for drugs in lipophilic and hydrophilic forms, respectively.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Namazi H,Jafarirad Sdoi
10.1016/j.ijpharm.2011.01.007subject
Has Abstractpub_date
2011-04-04 00:00:00pages
167-73issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)00021-4journal_volume
407pub_type
杂志文章abstract：:A quality-by-design (QbD) principle, including process analytical technology, is becoming the principal idea in drug development and manufacturing. The implementation of QbD into product development and manufacturing requires larger resources, both human and financial, however, large-scale production can be establishe...
journal_title：International journal of pharmaceutics
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更新日期：2008-04-16 00:00:00
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