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Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch.

Abstract：

:The hamster cheek pouch mucosa was selected as a substitute for the human buccal mucosa in an in vitro permeation study. Considering that a keratinized layer is not present in the human buccal mucosa, keratinized epithelial-free hamster cheek pouch (KEF-membrane) was prepared by chemical splitting. To confirm the usefulness of the KEF-membrane, a permeation study was conducted using several drugs with different lipophilicities. The permeability coefficient of hydrophilic drugs through the KEF-membrane (Pkef) was significantly greater than that through a viable KEF-membrane (Pkef-viable), which was estimated by using the permeability coefficient of the viable full-thickness membrane and that of the keratinized layer. On the other hand, the Pkef values of lipophilic drugs were comparable with the Pkef-viable values. Furthermore, the ratio of these P values (Pkef/Pkef-viable) decreased with increasing lipophilicity of drugs. These findings indicate that the KEF-membrane may be useful for buccal permeation studies of lipophilic drugs.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Tsutsumi K,Obata Y,Takayama K,Isowa K,Nagai T

doi

10.1016/s0378-5173(98)00329-9

keywords:

subject

Has Abstract

pub_date

1999-01-15 00:00:00

pages

7-14

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378517398003299

journal_volume

177

pub_type

杂志文章

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