当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoprotein- and cytochrome P4503A-mediated herb-drug interactions.

Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoprotein- and cytochrome P4503A-mediated herb-drug interactions.

Abstract：

:Danshen (Salvia miltiorrhiza) contains tanshinones, which inhibit P-glycoprotein (P-gp) and the cytochrome P450 (CYP) system. In the present study, we evaluated the possible pharmacokinetic interactions of Danshen extract with docetaxel and clopidogrel in rats. Docetaxel (5 mg/kg intravenously and 40 mg/kg orally) or clopidogrel (30 mg/kg orally) was administered to rats with or without oral co-administration of Danshen (400 mg/kg). Co-administration of Danshen did not affect the plasma concentration profiles and pharmacokinetic parameters of docetaxel and clopidogrel, whereas cyclosporine A, a P-gp and CYP3A inhibitor, significantly influenced the pharmacokinetics of co-administered docetaxel and clopidogrel. Orally administered Danshen had no substantial effect on the pharmacokinetics of docetaxel and clopidogrel, suggesting the negligible safety concern of Danshen in P-gp- and CYP3A-mediated interactions in vivo.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Lee JH,Shin YJ,Kim HJ,Oh JH,Jang YP,Lee YJ

doi

10.1016/j.ijpharm.2011.03.031

subject

Has Abstract

pub_date

2011-05-30 00:00:00

pages

68-74

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)00248-1

journal_volume

410

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Synergistic enhancement of anticancer therapeutic efficacy of HPMA copolymer doxorubicin conjugates via combination of ligand modification and stimuli-response srategies.

    abstract：:N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymer has been extensively studied as drug carrier for tumor therapy. Due to the Enhanced Permeability and Retention (EPR) effect, HPMA copolymer drug conjugates are able to be passively accumulated in the tumor site. Currently, efficient uptake of this polymeric system by...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.12.018

    authors： Li L,Zhou M,Huang Y

    更新日期：2018-01-30 00:00:00

  • Single-ligand dual-targeting irinotecan liposomes: Control of targeting ligand display by pH-responsive PEG-shedding strategy to enhance tumor-specific therapy and attenuate toxicity.

    abstract：:Along with the malignant proliferation of tumor requiring nutrients, the expression of L-type amino acid transporter 1(LAT1) and amino acid transporter B0,+ (ATB0,+) in cancer cells is up-regulated that can be used as new targets for active targeting of tumor. However, since normal cells also express amino acid transp...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119680

    authors： Wang Z,Lin X,Chi D,Xu Z,Lin G,Liu H,Sun J,He Z,Wang Y

    更新日期：2020-09-25 00:00:00

  • Evaluation and structure-activity relationship of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network.

    abstract：:The effect of 35 newly synthesized O-ethylmenthol (MET) derivatives on percutaneous absorption of ketoprofen was investigated in rats. In order to understand the relationship between the structure of compounds and promoting activity (structure-activity relationship), an artificial neural network (ANN) was employed. In...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00608-6

    authors： Obata Y,Li CJ,Fujikawa M,Takayama K,Sato H,Higashiyama K,Isowa K,Nagai T

    更新日期：2001-01-16 00:00:00

  • Mucoadhesivity and release properties of quaternary ammonium-chitosan conjugates and their nanoparticulate supramolecular aggregates: an NMR investigation.

    abstract：:Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium-chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profile of dexamethasone...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.018

    authors： Uccello-Barretta G,Balzano F,Aiello F,Senatore A,Fabiano A,Zambito Y

    更新日期：2014-01-30 00:00:00

  • Novel applications of ubiquinone biopolymer nanocarriers for preventive and regenerative therapeutics: The Saccharomyces cerevisiae paradigm.

    abstract：:Since the last decade, nanodispersed drug delivery systems gain increasingly more importance for therapeutic research fields. The forced transport to the centers of inflammation is supposed to take advantage as a novel strategic approach. Thus, the focus of this study was to investigate the applicability of ubiquinone...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.11.034

    authors： Hoennscheidt C,Margaritis A,Krull R

    更新日期：2015-01-15 00:00:00

  • Systematic modifications of amino acid-based organogelators for the investigation of structure-property correlations in drug delivery system.

    abstract：:Thermogels, used as multi-functional drug-loading materials, have properties that mainly rely on their gelator structure. Although a large variety of organogel systems are used as drug delivery carriers, relatively few have been investigated in terms of their structure-property correlations based on amino acid derivat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.043

    authors： Hu B,Sun W,Li H,Sui H,Li S

    更新日期：2018-08-25 00:00:00

  • Permeability of surface-modified polyamidoamine (PAMAM) dendrimers across Caco-2 cell monolayers.

    abstract：:Aim of this study was to prepare polyamine-conjugated PAMAM dendrimers and study their permeability across Caco-2 cell monolayers. Polyamines, namely, arginine and ornithine were conjugated to the amine terminals of the G4 PAMAM dendrimers by Fmoc synthesis. The apical-to-basolateral (AB) and basolateral-to-apical (BA...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.08.033

    authors： Pisal DS,Yellepeddi VK,Kumar A,Kaushik RS,Hildreth MB,Guan X,Palakurthi S

    更新日期：2008-02-28 00:00:00

  • Dispersibility of lactose fines as compared to API in dry powders for inhalation.

    abstract：:This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone Dipropionate (BDP) as model API. The total load of fine particles is kept constant in the formulations while the proportions of API and lactose fines are varied. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.03.004

    authors： Thalberg K,Åslund S,Skogevall M,Andersson P

    更新日期：2016-05-17 00:00:00

  • Effect of structural factors on release profiles of camptothecin from block copolymer conjugates with high load of drug.

    abstract：:The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of d-PLA units and poly(ethylene glycol) methyl ether m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.01.022

    authors： Plichta A,Kowalczyk S,Olędzka E,Sobczak M,Strawski M

    更新日期：2018-03-01 00:00:00

  • Application of statistical experimental design to study the formulation variables influencing the coating process of lidocaine liposomes.

    abstract：:In this paper, we have used statistical experimental design to investigate the effect of several factors in coating process of lidocaine hydrochloride (LID) liposomes by a biodegradable polymer (chitosan, CH). These variables were the concentration of CH coating solution, the dripping rate of this solution on the lipo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.01.024

    authors： González-Rodríguez ML,Barros LB,Palma J,González-Rodríguez PL,Rabasco AM

    更新日期：2007-06-07 00:00:00

  • 3D printed orodispersible films with Aripiprazole.

    abstract：:Three dimensional printing technology is gaining in importance because of its increasing availability and wide applications. One of the three dimensional printing techniques is Fused Deposition Modelling (FDM) which works on the basis of hot melt extrusion-well known in the pharmaceutical technology. Combination of fu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.05.052

    authors： Jamróz W,Kurek M,Łyszczarz E,Szafraniec J,Knapik-Kowalczuk J,Syrek K,Paluch M,Jachowicz R

    更新日期：2017-11-30 00:00:00

  • Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer.

    abstract：:The main purpose of this study was to develop self-emulsifying drug delivery systems (SEDDS) for the improvement of the stability of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) after released from poly (D,L-lactide-co-glycolide) (PLGA) wafer and to evaluate its in vitro antitumor activity against 9L gliosarcoma cells....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.03.034

    authors： Chae GS,Lee JS,Kim SH,Seo KS,Kim MS,Lee HB,Khang G

    更新日期：2005-09-14 00:00:00

  • A novel remote controlled capsule for site-specific drug delivery in human GI tract.

    abstract：:Remote controlled capsule (RCC) has been extensively used in the field of site-specific drug delivery. It is a potent tool to study the regional drug absorption of the gastrointestinal (GI) tract that provides pharmaceutical scientists with significant pharmacokinetics data for oral drug formulation development. In pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.08.026

    authors： Xitian P,Hongying L,Kang W,Yulin L,Xiaolin Z,Zhiyu W

    更新日期：2009-12-01 00:00:00

  • Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity.

    abstract：:Lipid-based formulations can be effective drug delivery systems for poorly water-soluble chemical entities, provided they are designed with careful selection of the excipients, based on their role in the delivery system and in relation to drug properties. The primary factor leading to increased bioavailability is the ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.09.009

    authors： Jannin V,Chevrier S,Michenaud M,Dumont C,Belotti S,Chavant Y,Demarne F

    更新日期：2015-11-10 00:00:00

  • Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system.

    abstract：:Poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) copolymers are important synthetic biomedical materials with amphiphilicity, controlled biodegradability, and great biocompatibility. They have great potential application in the fields of nanotechnology, tissue engineering, pharmaceutics, and medicinal chemis...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2009.07.033

    authors： Wei X,Gong C,Gou M,Fu S,Guo Q,Shi S,Luo F,Guo G,Qiu L,Qian Z

    更新日期：2009-10-20 00:00:00

  • Tablet capping predictions of model materials using multivariate approach.

    abstract：:The present study demonstrated the prediction of predominant root causes of capping behavior as a function of the powder rheological and the mechanical behavior of Acetaminophen (APAP) and Ibuprofen (IBU). The authors analyzed powder rheological properties for powder blend permeability, pressure drop, and cohesion. Th...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118548

    authors： Basim P,Haware RV,Dave RH

    更新日期：2019-10-05 00:00:00

  • Does ciprofloxacin interact with neutral bilayers? An aspect related to its antimicrobial activity.

    abstract：:Ciprofloxacin (CPX) physicochemical properties, mainly hydrophobicity and microspeciation, appear to be related with the ability of this drug to adsorb and diffuse through lipid environments. We have combined the information from fluorescence anisotropy, quenching and epifluorescence of phospholipid monolayers, to exp...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00633-6

    authors： Hernández-Borrell J,Montero MT

    更新日期：2003-02-18 00:00:00

  • Developability assessment of clinical drug products with maximum absorbable doses.

    abstract：:Maximum absorbable dose refers to the maximum amount of an orally administered drug that can be absorbed in the gastrointestinal tract. Maximum absorbable dose, or D(abs), has proved to be an important parameter for quantifying the absorption potential of drug candidates. The purpose of this work is to validate the us...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.02.003

    authors： Ding X,Rose JP,Van Gelder J

    更新日期：2012-05-10 00:00:00

  • Risperidone solid dispersion for orally disintegrating tablet: its formulation design and non-destructive methods of evaluation.

    abstract：:The focus of present investigation was to assess the utility of non-destructive techniques in the evaluation of risperidone solid dispersions (SD) with methyl-β-cyclodextrin (MBCD) and subsequent incorporation of the SD into orally disintegrating tablets (ODT) for a faster release of risperidone. The SD was prepared b...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.08.025

    authors： Rahman Z,Zidan AS,Khan MA

    更新日期：2010-11-15 00:00:00

  • Broad spectrum bioactive sunscreens.

    abstract：:The development of sunscreens containing reduced concentration of chemical UV filters, even though, possessing broad spectrum effectiveness with the use of natural raw materials that improve and infer UV absorption is of great interest. Due to the structural similarities between polyphenolic compounds and organic UV f...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.06.031

    authors： Velasco MV,Sarruf FD,Salgado-Santos IM,Haroutiounian-Filho CA,Kaneko TM,Baby AR

    更新日期：2008-11-03 00:00:00

  • Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres.

    abstract：:The development of a single-dose tetanus vaccine based on Poly(Lactic acid) (PLA) or Poly(Lactide-co-Glycolide) (PLGA) microspheres has been complicated due to the instability of tetanus toxoid (TT) inside these systems. Herein we report an attempt to re-design PLGA microspheres by co-encapsulating TT in the dry solid...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00178-7

    authors： Sánchez A,Villamayor B,Guo Y,McIver J,Alonso MJ

    更新日期：1999-08-20 00:00:00

  • Sinomenine hydrochloride loaded thermosensitive liposomes combined with microwave hyperthermia for the treatment of rheumatoid arthritis.

    abstract：:The conventional medications are still facing a huge challenge for the treatment of rheumatoid arthritis (RA). Thus, looking for an effective therapy of RA has became an urgent issue nowadays. In this study, a novel thermosensitive liposome loaded with sinomenine hydrochloride (SIN-TSL) was developed by a pH gradient ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.119001

    authors： Shen Q,Zhang X,Qi J,Shu G,Du Y,Ying X

    更新日期：2020-02-25 00:00:00

  • Electrospun protein nanofibers in healthcare: A review.

    abstract：:Electrospun nanofibers are being utilized for a wide range of healthcare applications. A plethora of natural and synthetic polymers are exploited for their ability to be electrospun and replace the complex habitat provided by the extracellular matrix for the cells. The fabrication of nanofibers can be tuned to act as ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.03.013

    authors： Babitha S,Rachita L,Karthikeyan K,Shoba E,Janani I,Poornima B,Purna Sai K

    更新日期：2017-05-15 00:00:00

  • In-line monitoring of pellet coating thickness growth by means of visual imaging.

    abstract：:Coating thickness is the most important attribute of coated pharmaceutical pellets as it directly affects release profiles and stability of the drug. Quality control of the coating process of pharmaceutical pellets is thus of utmost importance for assuring the desired end product characteristics. A visual imaging tech...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.04.066

    authors： Oman Kadunc N,Sibanc R,Dreu R,Likar B,Tomaževič D

    更新日期：2014-08-15 00:00:00

  • Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate.

    abstract：:Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) and it is mainly administered either orally or by subcutaneous (SC) injection, which are not so satisfactory. While orally administered MTX is associated with variable bioavailability and cause...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119580

    authors： Tekko IA,Chen G,Domínguez-Robles J,Thakur RRS,Hamdan IMN,Vora L,Larrañeta E,McElnay JC,McCarthy HO,Rooney M,Donnelly RF

    更新日期：2020-08-30 00:00:00

  • Characterization of alginate/poly-L-lysine particles as antisense oligonucleotide carriers.

    abstract：:The gel forming characteristics of alginate in the presence of calcium ions and further crosslinking with poly-L-lysine led to the formation of sponge-like nano- and microparticles. The particle size was varied by adjusting the final concentrations of and proportions between the components. The region for particle for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00030-3

    authors： González Ferreiro M,Tillman L,Hardee G,Bodmeier R

    更新日期：2002-06-04 00:00:00

  • Investigation of physicochemical factors affecting the stability of a pH-modulated solid dispersion and a tablet during storage.

    abstract：:The stability of solid dispersions (SD) during storage is of concern. We prepared the pH-modulated SD (pSD) and compressed tablets consisting of polyethylene glycol (PEG) 6000 as a carrier, drug and MgO (alkalizer). Telmisartan (TEL), an ionizable poorly water-soluble drug, was chosen as a model drug. The changes in p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.04.065

    authors： Tran PH,Tran TT,Park JB,Min DH,Choi HG,Han HK,Rhee YS,Lee BJ

    更新日期：2011-07-29 00:00:00

  • Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals.

    abstract：:Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-car...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.05.001

    authors： Chu J,Cheng YL,Rao AV,Nouraei M,Zarate-Muñoz S,Acosta EJ

    更新日期：2014-08-25 00:00:00

  • Stability and activity of hydroxyethyl starch-coated polyplexes in frozen solutions or lyophilizates.

    abstract：:Despite their great potential, gene delivery polyplexes have a number of limitations, including their tendency for aggregation in vivo or upon storage. In previous studies, we could show that hydroxyethyl starch (HES)-decoration of polyplexes reduces aggregation in vitro and in vivo. The current study investigates the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.04.020

    authors： Noga M,Edinger D,Wagner E,Winter G,Besheer A

    更新日期：2014-07-20 00:00:00

  • Slow-release of famotidine from tablets consisting of chitosan/sulfobutyl ether β-cyclodextrin composites.

    abstract：:An intermolecular complex formed from a 1:1 weight ratio of chitosan (CS, molecular weight 30 kDa) and sulfobutyl ether β-cyclodextrin (SBE-β-CyD, degree of substitution 7) was less soluble than either of the original components. The release of famotidine from tablets composed of a simple mixture of CS and SBE-β-CyD i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.04.022

    authors： Anraku M,Hiraga A,Iohara D,Pipkin JD,Uekama K,Hirayama F

    更新日期：2015-06-20 00:00:00