Abstract：
:The aim of the current study is to explore the potential of PEG-30-dipolyhydroxystearate (Cithrol(®) DPHS) and Soluplus(®) as ingredients in novel semisolid self-nanoemulsifying drug delivery systems (SNEDDS). Semisolid SNEDDS consisting of Cithrol(®) DPHS, Capmul(®) MCM and Kolliphor(®) HS 15 were successfully prepared. The formulations were comprehensively characterized by photon correlation spectroscopy (PCS), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), electron spin resonance (ESR) and proton nuclear magnetic resonance ((1)H NMR). All formulations were semisolid at room temperature and melted at body temperature. The hydrodynamic diameter of the dispersions was less than 25 nm. The ratio Cithrol(®) DPHS:Capmul(®) MCM was found to be critical for the dispersibility and the stability of the formed nanoemulsion.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Hassan TH,Metz H,Mäder Kdoi
10.1016/j.ijpharm.2014.10.063subject
Has Abstractpub_date
2014-12-30 00:00:00pages
506-18issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(14)00786-8journal_volume
477pub_type
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