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Pharmaceutical grade phyllosilicate dispersions: the influence of shear history on floc structure.

Abstract：

:The effect of mixing conditions on the flow curves of some clay-water dispersions was studied. Two Spanish fibrous phyllosilicates (sepiolite from Vicálvaro and palygorskite from Turón) and a commercial bentonite (Bentopharm Copyright, UK) were selected as model clays. The disperse systems were made up using a rotor-stator mixer working at two different mixing rates (1000 and 8000 rpm), for periods of 1 and 10 min. Rheological measurements were taken and the corresponding flow curves obtained immediately after interposition and then after a period of 24 h under low shear caused by a roller apparatus. Aqueous sepiolite dispersions showed the highest viscosity and were easily interposed, whereas palygorskite dispersions were more difficult to obtain, resulting in low to medium viscosity gels. Bentonite dispersions provided medium viscosity systems, which greatly increased their viscosity after the low shear treatment (as a result of swelling), whereas the viscosity of the fibrous clays stayed at approximately the same values or even decreased. A linear relation was found between mixing energy and apparent viscosity in the bentonite systems, while apparent viscosity in the sepiolite samples was related to mixing power, with minor influence of mixing times. All the systems studied had thixotropic behaviour, changing from clearly positive to even negative thixotropy in some palygorskite systems. Finally, we studied the effect of drastic pH changes on the system structure. Results showed that rheological properties were highly sensitive to pH in the fibrous dispersions, but less sensitive behaviour was found in the laminar clay systems.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Viseras C,Meeten GH,Lopez-Galindo A

doi

10.1016/s0378-5173(99)00075-7

keywords:

subject

Has Abstract

pub_date

1999-05-10 00:00:00

pages

7-20

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(99)00075-7

journal_volume

182

pub_type

杂志文章

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