Modified local diatomite as potential functional drug carrier--A model study for diclofenac sodium.


:Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (∼373mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8h) and those containing physical mixture of the same composition (up to 45% after 8h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.


Int J Pharm


Janićijević J,Krajišnik D,Čalija B,Vasiljević BN,Dobričić V,Daković A,Antonijević MD,Milić J




Has Abstract


2015-12-30 00:00:00














  • Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles.

    abstract::We developed several kinds of fentanyl-loaded poly(L-lactide-co-glycolide) (PLGA) microspheres (FMS) for sustained release of fentanyl. FMS were prepared by an emulsion solvent-evaporation method. In this study, the influences of several preparation parameters, such as initial drug loading, polymer concentration, and ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Choi HS,Seo SA,Khang G,Rhee JM,Lee HB

    更新日期:2002-03-02 00:00:00

  • Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.

    abstract::Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Souto EB,Wissing SA,Barbosa CM,Müller RH

    更新日期:2004-06-18 00:00:00

  • Anticancer effect of X-Ray triggered methotrexate conjugated albumin coated bismuth sulfide nanoparticles on SW480 colon cancer cell line.

    abstract::The application of nanoparticles (NPs) as radio-sensitizers and carriers has opened up a new horizon to overcome the limitations of chemo and radiotherapy. In this study, bovine serum albumin-coated Bi2S3 NPs (Bi2S3@BSA NPs) were synthesized and evaluated in terms of their ability to be used as a radio-sensitizer and ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Faghfoori MH,Nosrati H,Rezaeejam H,Charmi J,Kaboli S,Johari B,Danafar H

    更新日期:2020-05-30 00:00:00

  • Impact of implant composition of twin-screw extruded lipid implants on the release behavior.

    abstract::The development of vaccine delivery systems that will remove or reduce the need for repeated dosing has led to the investigation of sustained release systems. In this context, the duration of antigen release is of great importance as is the requirement for concomitant adjuvant release. In this work, lipid implants con...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Even MP,Bobbala S,Kooi KL,Hook S,Winter G,Engert J

    更新日期:2015-09-30 00:00:00

  • Development of new polymer-based particulate systems for anti-glioma vaccination.

    abstract::Biodegradable and biocompatible microspheres represent a promising alternative to conventional adjuvants for anti-tumour vaccination. Focusing on glioma, we developed two poly(D,L-lactide-co-glycolide) (PLGA)-based particulate systems presenting tumour antigens associated with plasma membranes or with cell lysates. Gl...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Sapin A,Garcion E,Clavreul A,Lagarce F,Benoit JP,Menei P

    更新日期:2006-02-17 00:00:00

  • Detection and characterization of protein aggregates by fluorescence microscopy.

    abstract::Aggregation may compromise the stability as well as the biological activity of protein drugs. Detection of protein aggregates is needed in the process of protein characterization and during optimization of pharmaceutical formulations. This paper describes a technique, which consists of analysing protein aggregates by ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Demeule B,Gurny R,Arvinte T

    更新日期:2007-02-01 00:00:00

  • Interaction of cationic partial dendrimers with charged and neutral liposomes.

    abstract::Amphipathic partial dendrimers having three lipidic (C(14)) chains coupled to dendritic lysine head groups with eight, 16 or 32 free terminal amino groups have been synthesised by solid-phase peptide synthesis. Liposomes were prepared with positive, negative and neutral charge using the dehydration-rehydration method ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Purohit G,Sakthivel T,Florence AT

    更新日期:2001-02-19 00:00:00

  • Design, synthesis and evaluation of N-acetyl glucosamine (NAG)-PEG-doxorubicin targeted conjugates for anticancer delivery.

    abstract::Efficacy of anticancer drug is limited by the severe adverse effects induced by drug; therefore the crux is in designing delivery systems targeted only to cancer cells. Toward this objectives, we propose, synthesis of poly(ethylene glycol) (PEG)-doxorubicin (DOX) prodrug conjugates consisting N-acetyl glucosamine (NAG...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Pawar SK,Badhwar AJ,Kharas F,Khandare JJ,Vavia PR

    更新日期:2012-10-15 00:00:00

  • A novel antibacterial agent based on AgNPs and Fe3O4 loaded chitin microspheres with peroxidase-like activity for synergistic antibacterial activity and wound-healing.

    abstract::In this study, a novel antibacterial agent was developed based on chitin nanofibrous microspheres loaded with AgNPs and Fe3O4 nanoparticles (Ag-Fe3O4-NMs) for synergistic antibacterial activity and wound healing. Ag-Fe3O4-NMs was prepared via an in situ synthetic method which showed an excellent porosity and wettabili...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Yu N,Cai T,Sun Y,Jiang C,Xiong H,Li Y,Peng H

    更新日期:2018-12-01 00:00:00

  • Preparation and biodisposition of methoxypolyethylene glycol amine-poly(DL-lactic acid) copolymer nanoparticles loaded with pyrene-ended poly(DL-lactic acid).

    abstract::A formyl group-ended poly(DL-lactic acid) (PLA-aldehyde), synthesized in the same manner as reported previously, was utilized to produce the polymeric marker for PLA-related nanoparticles. Namely, pyrene-ended poly(DL-lactic acid) (PLA-pyrene) was prepared as a polymeric marker by the reductive amination of PLA-aldehy...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Sasatsu M,Onishi H,Machida Y

    更新日期:2008-06-24 00:00:00

  • Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously.

    abstract::Drug solubility and lymphatic transport enhancements are two main pathways to improve drug oral bioavailability for microemulsions. However, it is not easy to have both achieved simultaneously because excipients used for improving lymphatic transport were usually insufficient in forming microemulsions and solubilizing...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Xing Q,Song J,You X,Xu D,Wang K,Song J,Guo Q,Li P,Wu C,Hu H

    更新日期:2016-09-25 00:00:00

  • Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin.

    abstract::As with many other anti-cancer agents, docetaxel is a substrate for ATP-binding cassette transporters such as P-glycoprotein and its metabolism is mainly catalysed by CYP3A. In order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal P-glycoprote...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Yan YD,Kim DH,Sung JH,Yong CS,Choi HG

    更新日期:2010-10-31 00:00:00

  • Enhanced oral delivery of alendronate by sucrose fatty acids esters in rats and their absorption-enhancing mechanisms.

    abstract::Oral delivery is the most fascinating route for interminable drug remedy. However, the intestinal absorption of alendronate (ALN), a bisphosphonate drug after oral administration is very poor. Absorption enhancers, which help to achieve the efficiency-safety balance, are considered one of the most promising agents for...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Alama T,Katayama H,Hirai S,Ono S,Kajiyama A,Kusamori K,Katsumi H,Sakane T,Yamamoto A

    更新日期:2016-12-30 00:00:00

  • Enabling real time release testing by NIR prediction of dissolution of tablets made by continuous direct compression (CDC).

    abstract::A method for predicting dissolution profiles of directly compressed tablets for a fixed sustained release formulation manufactured in a continuous direct compaction (CDC) system is presented. The methodology enables real-time release testing (RTRt). Tablets were made at a target drug concentration of 9% Acetaminophen,...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Pawar P,Wang Y,Keyvan G,Callegari G,Cuitino A,Muzzio F

    更新日期:2016-10-15 00:00:00

  • Redox-responsive microbeads containing thiolated pectin-doxorubicin conjugate inhibit tumor growth and metastasis: An in vitro and in vivo study.

    abstract::The objective of this study was to investigate the in vitro cytotoxicity and in vivo anticancer efficacy of redox-responsive microbeads containing thiolated pectin-doxorubicin (DOX) conjugate. Oral microbeads were coated with an enteric polymer to protect the drug from release in the upper gastrointestinal (GI) tract ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Cheewatanakornkool K,Niratisai S,Dass CR,Sriamornsak P

    更新日期:2018-07-10 00:00:00

  • An effective novel delivery strategy of rasagiline for Parkinson's disease.

    abstract::This is the first report on the efficacy of a new controlled release system developed for rasagiline mesylate (RM) in a rotenone-induced rat model of Parkinson's disease (PD). PLGA microspheres in vitro released RM at a constant rate of 62.3 μg/day for two weeks. Intraperitoneal injection of rotenone (2 mg/kg/day) to ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Fernández M,Negro S,Slowing K,Fernández-Carballido A,Barcia E

    更新日期:2011-10-31 00:00:00

  • Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles.

    abstract::Superparamagnetic iron oxide nanoparticles (SPIO-NPs) have traditionally been used as MRI contrast agent for disease imaging via passive targeting. However, there has been an increasing interest in the development of SPIO-NPs to cellular-specific targeting for imaging and drug delivery currently. The objective of our ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Fan C,Gao W,Chen Z,Fan H,Li M,Deng F,Chen Z

    更新日期:2011-02-14 00:00:00

  • Photodynamic ultradeformable liposomes: Design and characterization.

    abstract::Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine and sodium cholate (6...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Montanari J,Perez AP,Di Salvo F,Diz V,Barnadas R,Dicelio L,Doctorovich F,Morilla MJ,Romero EL

    更新日期:2007-02-07 00:00:00

  • Developability assessment of clinical drug products with maximum absorbable doses.

    abstract::Maximum absorbable dose refers to the maximum amount of an orally administered drug that can be absorbed in the gastrointestinal tract. Maximum absorbable dose, or D(abs), has proved to be an important parameter for quantifying the absorption potential of drug candidates. The purpose of this work is to validate the us...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ding X,Rose JP,Van Gelder J

    更新日期:2012-05-10 00:00:00

  • Effect of structural factors on release profiles of camptothecin from block copolymer conjugates with high load of drug.

    abstract::The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of d-PLA units and poly(ethylene glycol) methyl ether m...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Plichta A,Kowalczyk S,Olędzka E,Sobczak M,Strawski M

    更新日期:2018-03-01 00:00:00

  • Quality by Design (QbD) approach to optimize the formulation of a bilayer combination tablet (Telmiduo®) manufactured via high shear wet granulation.

    abstract::A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated based on a Quality by Design (QbD) approach. The control and response factors were determined based on primary knowledge and the target values of the control tablet (Twynsta®). A D-optimal mixture design was used to obtain the opt...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Lee AR,Kwon SY,Choi DH,Park ES

    更新日期:2017-12-20 00:00:00

  • Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin.

    abstract::Amino poly(glycerol methacrylate)s (PGOHMAs) were synthesized from linear or star-shaped poly(glycidyl methacrylate)s (PGMA)s via ring opening reactions with 1,2-ethanediamine, 1,4-butanediamine and diethylenetriamine, respectively. The resulting cationic polymers were employed to form polyelectrolyte complexes (PECs)...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Lu X,Gao H,Li C,Yang YW,Wang Y,Fan Y,Wu G,Ma J

    更新日期:2012-02-28 00:00:00

  • Percutaneous absorption of non-steroidal anti-inflammatory drugs from in situ gelling xyloglucan formulations in rats.

    abstract::The potential of gels formed in situ by dilute aqueous solutions of a xyloglucan polysaccharide derived from tamarind seed as sustained release vehicles for percutaneous administration of non-steroidal anti-inflammatory drugs has been assessed by in vitro and in vivo studies. Chilled aqueous solutions of xyloglucan th...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Takahashi A,Suzuki S,Kawasaki N,Kubo W,Miyazaki S,Loebenberg R,Bachynsky J,Attwood D

    更新日期:2002-10-10 00:00:00

  • Transdermal delivery of naloxone: effect of water, propylene glycol, ethanol and their binary combinations on permeation through rat skin.

    abstract::The effect of the solvent systems water, ethanol (EtOH), propylene glycol (PG) and their binary combinations was studied on the ex vivo permeation profile of the opioid receptor antagonist, naloxone, through rat skin. Fourier transform-infrared (FT-IR) spectroscopic studies were done to investigate the effect of enhan...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Panchagnula R,Salve PS,Thomas NS,Jain AK,Ramarao P

    更新日期:2001-05-21 00:00:00

  • Dynamic behavior of a spring-powered micronozzle needle-free injector.

    abstract::Conventional injection is still the leading method to deliver macromolecular therapeutics. Needle injection is considered a low compliance administration strategy, principally due to pain and needle phobia. This has fostered the research on the development of alternative strategies to circumvent the skin barrier. Amon...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Schoubben A,Cavicchi A,Barberini L,Faraon A,Berti M,Ricci M,Blasi P,Postrioti L

    更新日期:2015-08-01 00:00:00

  • Physicochemical properties of tamoxifen hemicitrate sesquihydrate.

    abstract::A novel modification of tamoxifen [(Z)-2-[4-(1,2-diphenyl-1-butenyl) phenoxy]-N,N-dimethylethylamine] citrate, tamoxifen hemicitrate hydrate was prepared. The crystalline form was identified and characterized by powder and single crystal X-ray diffractometries, differential scanning calorimetry (DSC), thermal gravimet...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kojima T,Katoh F,Matsuda Y,Teraoka R,Kitagawa S

    更新日期:2008-03-20 00:00:00

  • Novel self-floating tablet for enhanced oral bioavailability of metformin based on cellulose.

    abstract::Metformin has several problems such as low bioavailability, short half-life, and narrow absorption window, sustained and site-specific drug delivery system is required. Floating drug delivery systems are very useful to achieve these purposes. However, conventional floating systems have several limitations; lag time, a...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Wook Huh H,Na YG,Kang H,Kim M,Han M,Mai Anh Pham T,Lee H,Baek JS,Lee HK,Cho CW

    更新日期:2021-01-05 00:00:00

  • Long-circulating lipoprotein-mimic nanoparticles for smart intravenous delivery of a practically-insoluble antineoplastic drug: Development, preliminary safety evaluations and preclinical pharmacokinetic studies.

    abstract::Chlorambucil (CHL) is a water-insoluble antineoplastic drug having a short elimination half-life. It suffers from remarkable differences in pharmacokinetics following oral administration. The current work aimed to assess safety and pharmacokinetics of CHL-loaded, lipoprotein-mimic, nanoparticles (NPs) following intrav...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Tadros MI,Al-Mahallawi AM

    更新日期:2015-09-30 00:00:00

  • Validation of a continuous granulation process using a twin-screw extruder.

    abstract::Using twin-screw granulation as particle size enlargement technique, the effect of modifying the screw configuration (number of mixing zones, configuration of kneading block) on granule quality, tablet properties and mixing efficiency was investigated. The amount of oversized agglomerates and yield was significantly i...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Van Melkebeke B,Vervaet C,Remon JP

    更新日期:2008-05-22 00:00:00

  • Development and evaluation of a tampering resistant transdermal fentanyl patch.

    abstract::With the increasing number of misuse and abuse of opioids, the resistance to tampering becomes an important attribute for transdermal opioid patches. In this study, drug-containing geopolymer granules were integrated into an adhesive matrix to improve the resistance of fast drug release against some common abuse techn...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Cai B,Engqvist H,Bredenberg S

    更新日期:2015-07-05 00:00:00