Modified local diatomite as potential functional drug carrier--A model study for diclofenac sodium.

Abstract:

:Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (∼373mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8h) and those containing physical mixture of the same composition (up to 45% after 8h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.

journal_name

Int J Pharm

authors

Janićijević J,Krajišnik D,Čalija B,Vasiljević BN,Dobričić V,Daković A,Antonijević MD,Milić J

doi

10.1016/j.ijpharm.2015.10.047

subject

Has Abstract

pub_date

2015-12-30 00:00:00

pages

466-74

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)30316-1

journal_volume

496

pub_type

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