当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Determination of nifedipine in human plasma and its use in bioequivalence study.

Determination of nifedipine in human plasma and its use in bioequivalence study.

Abstract：

:A sensitive atmospheric pressure chemical ionization liquid chromatographic-mass spectrometric (APCI-LC-MS) assay with positive ion mode has been developed for the determination of nifedipine in human plasma. In this method, nifedipine was extracted from human plasma using diethyl ether with dimethoxanate as the internal standard. Analysis was achieved on a BDS C(18) column with methanol-H(2)O (66:34, v/v) as the mobile phase. Sustained-release nifedipine tablets from DiSha (test, Weihai, China) and from GuoFeng (reference, Qingdao, China) were evaluated following a single 20mg oral dose to 20 healthy volunteers. Bioequivalence between the products was determined by calculating 90% confidence intervals (90% CI) for the ratio of C(max), AUC(0-t) and AUC(0-infinity) values for the test and reference products, using logarithmic transformed data. The 90% confidence intervals for the ratio of C(max) (86.6-105.2%), AUC(0-t) (97.8-110.9%) and AUC(0-infinity) (96.5-110.4%) values for the test and reference products are within the interval (80.0-125.0% for AUC, and 70-143% for C(max)), proposed by State of Food and Drug Administration [SFDA, 2005. Guidance for Bioavailability and Bioequivalence Studies for Chemical Drug Products in Human Being. China, p. 19]. It was concluded that the two sustained-release nifedipine tablets are bioequivalent in their rate and extent of absorption and, thus, may be used interchangeably.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Guo Y,Dai J,Qian G,Guo N,Ma Z,Guo X

doi

10.1016/j.ijpharm.2007.03.053

subject

Has Abstract

pub_date

2007-08-16 00:00:00

pages

91-6

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(07)00294-3

journal_volume

341

pub_type

杂志文章,随机对照试验

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Behaviour of silver nanoparticles in simulated saliva and gastrointestinal fluids.

    abstract：:Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust toxicological methods for evaluation of toxic potential of AgNPs and information on t...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.05.026

    authors： Pinďáková L,Kašpárková V,Kejlová K,Dvořáková M,Krsek D,Jírová D,Kašparová L

    更新日期：2017-07-15 00:00:00

  • β-Cyclodextrin encapsulation of nortriptyline HCl and amitriptyline HCl: Molecular insights from single-crystal X-ray diffraction and DFT calculation.

    abstract：:The β-CD encapsulation of two tricyclic antidepressants (TCAs), nortriptyline (NRT) HCl and amitriptyline (AMT) HCl (most widely used TCA), has been thoroughly investigated by single-crystal X-ray diffraction and DFT calculation for insights into the inclusion complexation. X-ray analysis reveals that both drugs inser...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118899

    authors： Aree T

    更新日期：2020-02-15 00:00:00

  • The consideration of indolicidin modification to balance its hemocompatibility and delivery efficiency.

    abstract：:Indolicidin (IL) is an antimicrobial peptide (AMP), which has been utilized as a cell penetrating peptide (CPP) for drug delivery. However, the hemolysis restricts its clinical application. Therefore, we investigated the delivery efficiency and hemocompatibility of IL and its derivatives. The transportation of fluorop...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.037

    authors： Tsai CW,Hu WW,Liu CI,Ruaan RC,Tsai BC,Jin SL,Chang Y,Chen WY

    更新日期：2015-10-15 00:00:00

  • An insight into powder entrainment and drug delivery mechanisms from a modified Rotahaler®.

    abstract：:This study aims to improve understanding of the powder fluidisation and aerosolisation processes unique to a split capsule dry powder inhaler. It uses a combination of dynamic real-time methods and a suite of powder material physicochemical characterisation methods. The study focused on examining the effect of differe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.038

    authors： Sim S,Margo K,Parks J,Howell R,Hebbink GA,Orlando L,Larson I,Leslie P,Ho L,Morton DA

    更新日期：2014-12-30 00:00:00

  • Quantification of surface composition and surface structure of inhalation powders using TOF-SIMS.

    abstract：:A multivariate TOF-SIMS methodology has been developed and applied to quantify surface composition and chemical distribution for dry powder blends. Surface properties are often critical to the behavior of powder formulations, especially in the case of dry powders for inhalation, as surface properties directly affect i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119666

    authors： Nicholas M,Josefson M,Fransson M,Wilbs J,Roos C,Boissier C,Thalberg K

    更新日期：2020-09-25 00:00:00

  • Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.

    abstract：:Paclitaxel is widely used to treat several types of solid tumors. The commercially available paclitaxel formulation contains Cremophor/ethanol as solubilizers. This study evaluated the effects of D-alpha-tocopheryl polyethylene glycol 400 succinate (TPGS 400) on the oral absorption of paclitaxel in mice. Mice were giv...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.04.013

    authors： Ho PY,Yeh TK,Yao HT,Lin HL,Wu HY,Lo YK,Chang YW,Chiang TH,Wu SH,Chao YS,Chen CT

    更新日期：2008-07-09 00:00:00

  • Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation.

    abstract：:N-Acetyl-l-cysteine (NAC) commonly used as an antidote in acetaminophen poisoning has shown promise in the treatment of neurological disorders such as cerebral palsy (CP). However, NAC suffers from drawbacks such as poor oral bioavailability and suboptimal blood-brain-barrier (BBB) permeability limiting its clinical s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.04.040

    authors： Yellepeddi VK,Mohammadpour R,Kambhampati SP,Sayre C,Mishra MK,Kannan RM,Ghandehari H

    更新日期：2018-07-10 00:00:00

  • Effect of varying the restriction degree of 4-aminopyridine release from HPMC matrices on the mechanism controlling the process.

    abstract：:Among different technological variables that influence drug release from hydrophilic matrices, different proportions of the polymer and a water-soluble excipient have been used to control the drug release properties. These variables were used to modify the drug release rate and to examine its effect on the mechanism c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00150-9

    authors： Martínez-González I,Villafuerte-Robles L

    更新日期：2003-05-12 00:00:00

  • Determination of bisphenol A in water and the medical devices used in hemodialysis treatment.

    abstract：:Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. The aim of this study is while taking into account the BPA originating in medical devices and the water used in dialysate production, to provide the first published investigation of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.03.003

    authors： Bacle A,Thevenot S,Grignon C,Belmouaz M,Bauwens M,Teychene B,Venisse N,Migeot V,Dupuis A

    更新日期：2016-05-30 00:00:00

  • In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery.

    abstract：:Cell-based and acute and subchronic in vivo toxicity profiles of a dendrimer based on melamine reveal that this class of molecules warrants additional study as vehicles for drug delivery. In cell culture, a substantial decrease in viability was observed at 0.1 mg/mL. For the acute studies, mice were administered 2.5, ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2004.04.023

    authors： Neerman MF,Zhang W,Parrish AR,Simanek EE

    更新日期：2004-08-20 00:00:00

  • A novel formulation of solubilised amphotericin B designed for ophthalmic use.

    abstract：:Amphotericin B (AmB) is a wide spectrum antifungal with low incidence of clinical resistance. However, there are no licensed topical formulations with AmB in most developed countries. Extemporaneous preparations of AmB are frequently prepared from available marketed parenteral formulations. Herein, a solution of AmB w...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.065

    authors： Serrano DR,Ruiz-Saldaña HK,Molero G,Ballesteros MP,Torrado JJ

    更新日期：2012-11-01 00:00:00

  • Evaluation of soluble fentanyl microneedles for loco-regional anti-nociceptive activity.

    abstract：:The use of opioids for treating acute and chronic pain condition is a common clinical practice. When delivered systemically, the analgesic activity is mediated through the central pathway, which although effective, leads to various adverse effects such as dependence, abuse and respiratory depression. Fentanyl is an op...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.04.066

    authors： Maurya A,Rangappa S,Bae J,Dhawan T,Ajjarapu SS,Murthy SN

    更新日期：2019-06-10 00:00:00

  • Effect of the combination of organic and inorganic filters on the Sun Protection Factor (SPF) determined by in vitro method.

    abstract：:This paper describes the effect on Sun Protection Factor (SPF) of the combination of inorganic and organic filters in sunscreen products as determined by an in vitro method. O/W emulsions containing inorganic filters, such as titanium dioxide and zinc oxide, combined with 18 EU-authorized UV-B organic filters were tes...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.05.047

    authors： El-Boury S,Couteau C,Boulande L,Paparis E,Coiffard LJ

    更新日期：2007-08-01 00:00:00

  • Predicting the gastrointestinal behaviour of modified-release products: utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers.

    abstract：:The establishment of physiologically relevant in vitro-in vivo correlations (IV-IVCs) is key for any biorelevant dissolution test. Historically, bicarbonate buffers have produced better correlations than compendial phosphate buffered media, though such tests are usually performed at a constant pH experiment, overlooki...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.09.003

    authors： Merchant HA,Goyanes A,Parashar N,Basit AW

    更新日期：2014-11-20 00:00:00

  • Enhanced antioxidation via encapsulation of isooctyl p-methoxycinnamate with sodium deoxycholate-mediated liposome endocytosis.

    abstract：:Isooctyl p-methoxycinnamate(OMC) is a commonly used chemical ultraviolet B sunscreen that suffers rapid degradation with current delivery systems following sun exposure. In this study, deoxycholate-mediated liposome (DOC-LS) endocytosis was employed to improve the antioxidation effects of OMC following topical adminis...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.010

    authors： Zhang Y,Shen L,Zhang K,Guo T,Zhao J,Li N,Feng N

    更新日期：2015-12-30 00:00:00

  • A theoretical approach to evaluate the release rate of acetaminophen from erosive wax matrix dosage forms.

    abstract：:To predict drug dissolution and understand the mechanisms of drug release from wax matrix dosage forms containing glyceryl monostearate (GM; a wax base), aminoalkyl methacrylate copolymer E (AMCE; a pH-dependent functional polymer), and acetaminophen (APAP; a model drug), we tried to derive a novel mathematical model ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.05.015

    authors： Agata Y,Iwao Y,Shiino K,Miyagishima A,Itai S

    更新日期：2011-07-29 00:00:00

  • In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate.

    abstract：:We demonstrate a rapidly formed cubic liquid crystalline phase, i.e. typically 1g cubic phase in less than 1 min confirmed by X-ray diffraction, consisting of an ether lipid, 1-glyceryl monooleyl ether (GME), an aprotic solvent (propylene glycol or pentane-1,5-diol) and water. The efficacy of the cubic formulation was...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.05.047

    authors： Evenbratt H,Jonsson C,Faergemann J,Engström S,Ericson MB

    更新日期：2013-08-16 00:00:00

  • Determination of promethazine hydrochloride and its preparations by highly accurate nephelometric titration.

    abstract：:A highly accurate nephelometric titration for the determination of promethazine hydrochloride and its preparations was presented. The titration operating conditions were studied and the solubility product constant of promethazine tetraphenylboron precipitation was determined. The result of the titration is comparable ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.043

    authors： Zhang Q,Zhan X,Li C,Lin T,Li L,Yin X,He N,Shi Y

    更新日期：2005-09-30 00:00:00

  • Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design.

    abstract：:The present study focused on the development and optimization of glycerosomes for dermal delivery of fisetin. The fisetin loaded glycerosomes formulation was optimized by Box-Behnken design. The independent variables were the lipoid S 100, glycerol, and sonication time, whereas the dependent variables were the vesicle...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119125

    authors： Moolakkadath T,Aqil M,Ahad A,Imam SS,Praveen A,Sultana Y,Mujeeb M

    更新日期：2020-03-30 00:00:00

  • Impact of controlled vacuum induced surface freezing on the freeze drying of human plasma.

    abstract：:During the freezing step of a typical freeze drying process, the temperature at which nucleation is induced is generally stochastically distributed, resulting in undesired within-batch heterogeneity. Controlled nucleation techniques have been developed to address this problem; these make it possible to trigger the for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119290

    authors： Arsiccio A,Matejtschuk P,Ezeajughi E,Riches-Duit A,Bullen A,Malik K,Raut S,Pisano R

    更新日期：2020-05-30 00:00:00

  • The quantification of small degrees of disorder in lactose using solution calorimetry.

    abstract：:There is a realisation that small quantities of amorphous material can have a significant impact on the properties of crystalline solids. Consequently there is a growing interest in quantifying the amount of amorphous material that is present in "crystalline powders". Success has been reported when using isothermal mi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00527-5

    authors： Hogan SE,Buckton G

    更新日期：2000-10-10 00:00:00

  • Dry powder inhalation of colistin sulphomethate in healthy volunteers: A pilot study.

    abstract：BACKGROUND:Pulmonary administration of the antimicrobial drugs colistin sulphomethate and tobramycin has been shown to be effective in slowing down pulmonary deterioration in cystic fibrosis (CF) patients. Both drugs are administered by liquid nebulisation, a technique known to have disadvantages. Dry powder inhalation...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijpharm.2006.11.021

    authors： Westerman EM,de Boer AH,Le Brun PPH,Touw DJ,Frijlink HW,Heijerman HGM

    更新日期：2007-04-20 00:00:00

  • Microencapsulation of amorphous solid dispersions of fenretinide enhances drug solubility and release from PLGA in vitro and in vivo.

    abstract：:The purpose of this study was to develop solid dispersions of fenretinide(4HPR), incorporate them into poly(lactic-co-glycolic)(PLGA) millicylindrical implants, and evaluate the resulting implants in vitro and in vivo for future applications in oral cancer chemoprevention. Due to the extreme hydrophobicity of 4HPR, 4H...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119475

    authors： Nieto K,Mallery SR,Schwendeman SP

    更新日期：2020-08-30 00:00:00

  • Nanodiamonds: Minuscule gems that ferry antineoplastic drugs to resistant tumors.

    abstract：:Remarkable efforts are currently devoted to the area of nanodiamonds (NDs) research due to their superior properties viz: biocompatibility, minute size, inert core, and tunable surface chemistry. The use of NDs for the delivery of anticancer drugs has been at the forefront of NDs applications owing to their ability to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2018.12.090

    authors： Ali MS,Metwally AA,Fahmy RH,Osman R

    更新日期：2019-03-10 00:00:00

  • Does ciprofloxacin interact with neutral bilayers? An aspect related to its antimicrobial activity.

    abstract：:Ciprofloxacin (CPX) physicochemical properties, mainly hydrophobicity and microspeciation, appear to be related with the ability of this drug to adsorb and diffuse through lipid environments. We have combined the information from fluorescence anisotropy, quenching and epifluorescence of phospholipid monolayers, to exp...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00633-6

    authors： Hernández-Borrell J,Montero MT

    更新日期：2003-02-18 00:00:00

  • Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs.

    abstract：:The buccal administration of ergotamine tartrate (ET) combined with polyvinyl alcohol (PVA) gel brought about higher plasma concentration of ET compared with that of oral administration of capsules in guinea-pigs. T(max) of ET in plasma of buccal administration was significantly smaller than that of oral administratio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00070-4

    authors： Tsutsumi K,Obata Y,Nagai T,Loftsson T,Takayama K

    更新日期：2002-05-15 00:00:00

  • Ascorbyl-dipalmitate-stabilised nanoemulsions as a potential localised treatment of inflammatory bowel diseases.

    abstract：:Current efforts on inflammatory bowel diseases (IBD) treatment are focused on strategies for localised drug delivery at the intestinal mucosa. Despite the potential of curcumin (CC) for IBD treatment, its low solubility and stability limit its application. Thus, the design of nanocarriers that focus CC delivery at the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119533

    authors： Plaza-Oliver M,Beloqui A,Santander-Ortega MJ,Castro-Vázquez L,Rodríguez-Robledo V,Arroyo-Jiménez MM,Préat V,Lozano MV

    更新日期：2020-08-30 00:00:00

  • Effect of storage on microstructural changes of Carbopol polymers tracked by the combination of positron annihilation lifetime spectroscopy and FT-IR spectroscopy.

    abstract：:Different types of Carbopols are frequently applied excipients of various dosage forms. Depending on the supramolecular structure, their water sorption behaviour could significantly differ. The purpose of the present study was to track the supramolecular changes of two types of Carbopol polymers (Carbopol 71G and Ultr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.06.028

    authors： Szabó B,Süvegh K,Zelkó R

    更新日期：2011-09-15 00:00:00

  • Strategies for maintaining the particle size of peptide DNA condensates following freeze-drying.

    abstract：:The particle size of peptide DNA condensates were studied after freeze-drying and rehydration as a function of sugar excipient, concentration, pH, DNA concentration, and peptide condensing agent. In the absence of an excipient, freeze-dried 50 microg/ml AlkCWK(18) (iodoacetic acid alkylated Cys-Typ-Lys(18)) DNA conden...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00435-x

    authors： Kwok KY,Adami RC,Hester KC,Park Y,Thomas S,Rice KG

    更新日期：2000-08-10 00:00:00

  • Evaluation of novel lipid based formulation of β-Artemether and Lumefantrine in murine malaria model.

    abstract：:The present investigation aims at formulating lipid based drug delivery system of β-Artemether and Lumefantrine and comparative pharmacological evaluation with innovator formulation. Commercial modified oil and indigenous natural fatty acids comprised the oily phase in developing lipidic formulation of β-Artemether an...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.033

    authors： Patil S,Suryavanshi S,Pathak S,Sharma S,Patravale V

    更新日期：2013-10-15 00:00:00