Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing.

abstract：:Nickel-titanium shape-memory alloys (NiTi-SMA) were coated with calcium phosphate by dipping in oversaturated calcium phosphate solution. The layer thickness (typically 5-20 micrometer) can be varied by choice of the immersion time. The porous nature of the layer of microcrystals makes it mechanically stable enough to...

journal_title：Biomaterials

authors： Choi J,Bogdanski D,Köller M,Esenwein SA,Müller D,Muhr G,Epple M

更新日期：2003-09-01 00:00:00

abstract：:Acute trauma or trauma associated with occlusal disturbance can produce tooth crack or fracture. Although several methods are proposed to treat the defect, however, the prognosis is generally poor. If the fusion of a tooth fracture by laser is possible, it will offer an alternative to extraction or at least serve as a...

journal_title：Biomaterials

authors： Lin CP,Tseng YC,Lin FH,Liao JD,Lan WH

更新日期：2001-03-01 00:00:00

abstract：:Therapeutic options to treat primary glioblastoma (GBM) tumors are scarce. GBM tumors with epidermal growth factor receptor (EGFR) mutations, in particular a constitutively active EGFRvIII mutant, have extremely poor clinical outcomes. GBM tumors with concurrent EGFR amplification and active phosphatase and tensin hom...

journal_title：Biomaterials

authors： Pedron S,Wolter GL,Chen JE,Laken SE,Sarkaria JN,Harley BAC

更新日期：2019-10-01 00:00:00

abstract：:Successful cell-based tissue engineering requires a rapid and thorough vascularization in order to ensure long-term implant survival and tissue integration. The vascularization of a scaffold is a complex process, and is modulated by the presence of transplanted cells, exogenous and endogenous signaling proteins, and t...

journal_title：Biomaterials

authors： Ghanaati S,Unger RE,Webber MJ,Barbeck M,Orth C,Kirkpatrick JA,Booms P,Motta A,Migliaresi C,Sader RA,Kirkpatrick CJ

更新日期：2011-11-01 00:00:00

abstract：:The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (MSC) chondrogenesis. In this study, we combined gene therapy and functional tissue engineering to develop engineered...

journal_title：Biomaterials

authors： Glass KA,Link JM,Brunger JM,Moutos FT,Gersbach CA,Guilak F

更新日期：2014-07-01 00:00:00

abstract：:In-stent restenosis is one of the most serious modes of failure of cardiovascular stent implant. Although drug-eluting stents have been proven to reduce in-stent restenosis, the nonspecific inhibitory effects of anti-proliferative drugs, such as rapamycin, result in delayed re-endothelialization and fatal late stent t...

journal_title：Biomaterials

authors： Zhang H,Ren KF,Chang H,Wang JL,Ji J

更新日期：2017-02-01 00:00:00

abstract：:This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

journal_title：Biomaterials

authors： Dey RK,Ray AR

更新日期：2003-08-01 00:00:00

abstract：:Thin sheets of nanofibrous (NF) poly(L-lactic acid) (PLLA) matrix were fabricated using a novel phase separation method, mimicking the structure of natural collagen fibers. In this study, the cell morphology, cytoskeleton and adhesion structure, proliferation and differentiation were investigated on NF PLLA matrix usi...

journal_title：Biomaterials

authors： Hu J,Liu X,Ma PX

更新日期：2008-10-01 00:00:00

abstract：:Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical performance of...

journal_title：Biomaterials

authors： Lomas RJ,Gillan HL,Matthews JB,Ingham E,Kearney JN

更新日期：2001-05-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is among the most aggressive cancers associated with massive infiltration of peritumoral parenchyma by migrating tumor cells. The infiltrative nature of GBM cells, the intratumoral heterogeneity concomitant with redundant signaling pathways likely underlie the inability of conventional an...

journal_title：Biomaterials

authors： Cosset E,Petty T,Dutoit V,Tirefort D,Otten-Hernandez P,Farinelli L,Dietrich PY,Preynat-Seauve O

更新日期：2016-11-01 00:00:00

abstract：:Multilayered coatings composed of mixtures of HA and P2O5-based bioactive glasses are of potential clinical benefit in orthopaedic and dental surgery. Pre-immersion of these materials has been reported to further enhance their efficacy in vivo, although the precise biological effects of this treatment are not yet know...

journal_title：Biomaterials

authors： Ferraz MP,Knowles JC,Olsen I,Monteiro FJ,Santos JD

更新日期：2000-04-01 00:00:00

abstract：:The systemic administration of immunosuppressive and anti-inflammatory drugs is routinely employed in organ transplantation to minimize graft rejection and improve graft survival. Localized drug delivery has the potential to improve transplant outcomes by providing sustained exposure to efficacious drug concentrations...

journal_title：Biomaterials

authors： Chang CA,Akinbobuyi B,Quintana JM,Yoshimatsu G,Naziruddin B,Kane RR

更新日期：2018-03-01 00:00:00

abstract：:Seven nominally identical samples of Na-free carbonate apatite (CO(3)Ap) were prepared by reaction of CaHPO(4) with ammonium carbonate solution at 70 degrees C over 3 days. They were studied by chemical analysis, Rietveld analysis of powder X-ray diffraction (XRD) data, Ca/P ratio determinations (quantitative phase an...

journal_title：Biomaterials

authors： Wilson RM,Dowker SE,Elliott JC

更新日期：2006-09-01 00:00:00

abstract：:In spite of tremendous demand for the development and implementation of effective therapeutic strategies, limitations are still associated with doxorubicin-induced cardiotoxicity. Arjunolic acid (AA) has been shown to possess a multitude of biological functions. The purpose of the present study was to explore whether ...

journal_title：Biomaterials

authors： Ghosh J,Das J,Manna P,Sil PC

更新日期：2011-07-01 00:00:00

abstract：:Samples of linear (additionally crosslinked) p(HEMA) with different amounts of fibrillar collagen were implanted into the popliteal region of rats. After 3 month, the implanted materials were harvested and examined by SEM. The implants underwent marked structural or morphological changes. While the fibrillar collagen ...

journal_title：Biomaterials

authors： Stol M,Cífková I,Tyrácková V,Adam M

更新日期：1991-07-01 00:00:00

abstract：:Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time. Cryopreservation/vitrific...

journal_title：Biomaterials

authors： Jomha NM,Elliott JA,Law GK,Maghdoori B,Forbes JF,Abazari A,Adesida AB,Laouar L,Zhou X,McGann LE

更新日期：2012-09-01 00:00:00

abstract：:The objective of this study is to develop a carrier for the controlled release of bone morphogenetic protein-2 (BMP-2) suitable for enhancement of the bone regeneration activity. Hydrogels with different water contents were prepared through glutaraldehyde crosslinking of gelatin with an isoelectric point of 9.0 under ...

journal_title：Biomaterials

authors： Yamamoto M,Takahashi Y,Tabata Y

更新日期：2003-11-01 00:00:00

abstract：:Cancer stem cells (CSCs) play pivotal roles in cancer metastasis, and strategies targeting cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The canonical Wnt/β-catenin pathway plays critical roles in CSC generation and maintenance as well as in normal stem cells. Non-specifically su...

journal_title：Biomaterials

authors： Li Y,Xiao Y,Lin HP,Reichel D,Bae Y,Lee EY,Jiang Y,Huang X,Yang C,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...

journal_title：Biomaterials

authors： Zhang J,Wang Z,Lin W,Chen S

更新日期：2014-09-01 00:00:00

abstract：:This study is aimed to develop a long-acting injectable formulation in treatment of type II diabetes. A glucoregulatory polypeptide, exenatide (EXT), was chosen as the model drug, and an aqueous block copolymer system with a sol-gel transition upon the increase of temperature was selected as the delivery matrix of EXT...

journal_title：Biomaterials

authors： Li K,Yu L,Liu X,Chen C,Chen Q,Ding J

更新日期：2013-04-01 00:00:00

abstract：:Injectable, biodegradable scaffolds are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural polysaccharides are ideal scaffolds as they resemble the extracellular matrices of tissues comprised of various glycosaminoglycans (GAGs). Here, we report a new class of biocompatible...

journal_title：Biomaterials

authors： Tan H,Chu CR,Payne KA,Marra KG

更新日期：2009-05-01 00:00:00

abstract：:We have shown that nanoparticles (NPs) conjugated to trans-activating transcriptor (TAT) peptide bypass the efflux action of P-glycoprotein and increase the transport of the encapsulated ritonavir, a protease inhibitor (PI), across the blood-brain-barrier (BBB) to the central nervous system (CNS). A steady increase in...

journal_title：Biomaterials

authors： Rao KS,Reddy MK,Horning JL,Labhasetwar V

更新日期：2008-11-01 00:00:00

abstract：:Liver diseases can be caused by viral infection, metabolic disorder, alcohol consumption, carcinoma or injury, chronically progressing to end-stage liver disease or rapidly resulting in acute liver failure. In either situation, liver transplantation is most often sought for life saving, which is, however, significantl...

journal_title：Biomaterials

authors： Zhang J,Zhao X,Liang L,Li J,Demirci U,Wang S

更新日期：2018-03-01 00:00:00

abstract：:Current tissue engineering scaffolds fabricated via solvent casting and porogen leaching methods suffer from the lack of control over parameters such as interconnectivity and pore geometry, properties that are a function of the fabrication process. The progress of tissue engineering would thus benefit from the ability...

journal_title：Biomaterials

authors： Hsieh TM,Ng CW,Narayanan K,Wan AC,Ying JY

更新日期：2010-10-01 00:00:00

abstract：:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

journal_title：Biomaterials

authors： Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

更新日期：2019-08-01 00:00:00

abstract：:Retinal degenerations cause permanent visual loss and affect millions world-wide. Presently, a novel treatment highlights the potential of using biodegradable polymer scaffolds to induce differentiation and deliver retinal progenitor cells for cell replacement therapy. In this study, we engineered and analyzed a micro...

journal_title：Biomaterials

authors： Redenti S,Neeley WL,Rompani S,Saigal S,Yang J,Klassen H,Langer R,Young MJ

更新日期：2009-07-01 00:00:00

abstract：:Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer treatment. Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and...

journal_title：Biomaterials

authors： Zhang R,Feng L,Dong Z,Wang L,Liang C,Chen J,Ma Q,Zhang R,Chen Q,Wang Y,Liu Z

更新日期：2018-04-01 00:00:00

abstract：:Hepatocytes derived from human pluripotent stem cells (hPSCs) are promising candidates for cell therapy and drug discovery. However, it remains challenging to efficiently purify hepatocytes from undesired cell types after differentiation and to accurately monitor grafted cells after transplantation. Indocyanine Green ...

journal_title：Biomaterials

authors： Park JY,Han J,Jung HS,Lee G,Kim HJ,Cho GS,Park HJ,Han C,Kim JS,Kim JH

更新日期：2019-11-01 00:00:00

abstract：:While subcutaneous tissue has been proposed as a potential site for pancreatic islet transplantation, concern remains that the microvasculature of subcutaneous tissue is too poor to support transplanted islets. In an effort to overcome this limitation, we evaluated whether fibrin gel with human adipose-derived stem ce...

journal_title：Biomaterials

authors： Bhang SH,Jung MJ,Shin JY,La WG,Hwang YH,Kim MJ,Kim BS,Lee DY

更新日期：2013-10-01 00:00:00

abstract：:Topographical cues, independent of biochemistry, generated by the extracellular matrix may have significant effects upon cellular behavior. Studies have documented that substratum topography has direct effects on the ability of cells to orient themselves, migrate, and produce organized cytoskeletal arrangements. Basem...

journal_title：Biomaterials

authors： Flemming RG,Murphy CJ,Abrams GA,Goodman SL,Nealey PF

更新日期：1999-03-01 00:00:00