Y-chromosome short tandem repeat (STR) haplotypes in a Campania population sample.

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Fibrinogen-based clot firmness is reported as the maximum amplitude (MA) when using the citrated functional fibrinogen (CFF) assay in thrombelastography (TEG), and as the maximum clot firmness (MCF) together with several clot amplitude parameters when using the FIBTEM assay in thromboelastometry (ROTEM). Con...

journal_title：Clinical chemistry and laboratory medicine

authors： Prüller F,Münch A,Preininger A,Raggam RB,Grinschgl Y,Krumnikl J,Toller W,Metzler H,Mahla E,Mangge H

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Measurement of late-night salivary cortisol concentrations is increasingly used as a screening test in suspected Cushing's syndrome. Cortisol concentrations are typically extremely low in late-night samples and discordant assay-specific reference ranges have been reported. Therefore, the aim of our study was...

journal_title：Clinical chemistry and laboratory medicine

authors： Vogeser M,Durner J,Seliger E,Auernhammer C

更新日期：2006-01-01 00:00:00

abstract：:Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% an...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonnet E,Genoux A,Bernard J,Fauvel J,Massip P,Perret B

更新日期：2007-01-01 00:00:00

abstract：:The present article proposes personal suggestions to improve determinations and clinical interpretation of results of lipoprotein(a) assays. Methods and procedures for sampling and quantification of the various isoforms of lipoprotein(a) in serum, plasma and urine are reviewed with the aim of improving the reliability...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Guidi G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Certain genetic polymorphisms can lead to differences in immunity function, resulting in different clinical outcomes for hepatitis B virus (HBV) patients. The aim of this study was to investigate the association between apolipoprotein E (ApoE) gene polymorphisms and HBV infection status in northern Chinese i...

journal_title：Clinical chemistry and laboratory medicine

authors： Yin Z,Xiong C,Wang Y,Zhou X,Yan SK

更新日期：2010-12-01 00:00:00

abstract：:Protein-coding genes comprise only 3% of the human genome, while the genes that are transcribed into RNAs but do not code for proteins occupy majority of the genome. Once considered as biological darker matter, non-coding RNAs are now being recognized as critical regulators in cancer genome. Among the many types of no...

journal_title：Clinical chemistry and laboratory medicine

authors： Ling H,Girnita L,Buda O,Calin GA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Query fever (Q fever) is a zoonotic infection, caused by the intracellular Gram-negative coccobacillus Coxiella burnetii. From 2007 until 2010, a large Q fever outbreak has occurred in the Netherlands. We studied traditional and less common inflammation markers in seronegative and seropositive patients with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Vissers E,de Jager CP,Hilbink M,Kusters R,van Gageldonk-Lafeber AB,Wever PC

更新日期：2012-02-04 00:00:00

abstract：BACKGROUND:Haptoglobin (Hp) is an abundant serum protein which binds extracorpuscular hemoglobin (Hb). Two alleles exist in humans for the Hp gene, denoted 1 and 2. Diabetic individuals with the Hp 2-2 genotype are at increased risk of developing vascular complications including heart attack, stroke, and kidney disease...

journal_title：Clinical chemistry and laboratory medicine

authors： Levy NS,Vardi M,Blum S,Miller-Lotan R,Afinbinder Y,Cleary PA,Paterson AD,Bharaj B,Snell-Bergeon JK,Rewers MJ,Lache O,Levy AP

更新日期：2013-08-01 00:00:00

abstract：:Thrombophilia can be identified in about half of all patients presenting with venous thromboembolism (VTE). Thrombophilia screening for various indications has increased tremendously, but whether the results of such tests help in the clinical management of patients is uncertain. Here, current recommendations for throm...

journal_title：Clinical chemistry and laboratory medicine

authors： Stegnar M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:There are several complementary English-language guidelines for the performance of the sweat chloride test. These guidelines also incorporate information for the collection of conductivity samples. However, recommendations for the measurement and reporting of sweat conductivity are less clear than for sweat ...

journal_title：Clinical chemistry and laboratory medicine

authors： Greaves RF,Jolly L,Massie J,Scott S,Wiley VC,Metz MP,Mackay RJ,Australasian Association of Clinical Biochemists Sweat Test Working Party in association with the Royal Australasian College of Pathologists Quality Assurance Programs.

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND:The usefulness of serum antibodies to common food antigens (immunoglobulin G4; IgG4) assay in management of patients suffering from food intolerance was assessed. METHODS:A total of 22 asymptomatic healthy subjects and 68 patients with symptoms referred for suspected food intolerance were studied. Serum IgG...

journal_title：Clinical chemistry and laboratory medicine

authors： Bernardi D,Borghesan F,Faggian D,Bianchi FC,Favero E,Billeri L,Plebani M

更新日期：2008-01-01 00:00:00

abstract：:Laboratory Medicine organizations and their professional members have a goal and responsibility to benefit the health and wellbeing of the patients and communities they serve. Newer genetics and biochemical techniques raise significant issues of community concern, impacting on privacy, informed consent, access to and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Burnett L,McQueen MJ,Jonsson JJ,Torricelli F,IFCC Taskforce on Ethics 13.7.

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Urinary enzymes, including the brush border enzyme alanine aminopeptidase (AAP), are reliable biomarkers of nephrotoxicity and represent early indicators of tubular damage. The aim of the present study was to develop and validate an automated urinary AAP activity assay. METHODS AND RESULTS:For this purpose,...

journal_title：Clinical chemistry and laboratory medicine

authors： Holdt B,Peters E,Nagel HR,Steiner M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:A crucial question when developing reference intervals is whether different subpopulations need their own reference interval or if a single joint reference interval can be used. It is reasonable to use partitioned reference intervals in situations where a single interval results in considerable variation in ...

journal_title：Clinical chemistry and laboratory medicine

authors： Gellerstedt M,Petersen PH

更新日期：2007-01-01 00:00:00

abstract：:Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The i...

journal_title：Clinical chemistry and laboratory medicine

authors： Hong YJ,Lee JK,Lee GH,Hong SI

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Serum free light chain (sFLC) measurements are increasingly important in the context of screening for monoclonal gammopathies, prognostic stratification, and monitoring of therapy responses. At the same time, analytical limitations have been reported with the currently available nephelometric and turbidimetr...

journal_title：Clinical chemistry and laboratory medicine

authors： Jacobs JFM,de Kat Angelino CM,Brouwers HMLM,Croockewit SA,Joosten I,van der Molen RG

更新日期：2018-01-26 00:00:00

abstract：:The concentration of leukocyte elastase/alpha1-proteinase inhibitor complexes in plasma and polymorphonuclear neutrophil extracts, and plasma trypsin inhibitory capacity were determined in 88 patients with type 2 diabetes and 47 control subjects. Higher values of these variables were found in patients as compared to c...

journal_title：Clinical chemistry and laboratory medicine

authors： Piwowar A,Knapik-Kordecka M,Warwas M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The objective of this study was to examine the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) for acute myocardial infarction (AMI) in patients with renal insufficiency, since this population has a high incidence of non-AMI elevations of hs-cTnT. METHODS:In this prospective study, we e...

journal_title：Clinical chemistry and laboratory medicine

authors： Huang H,Zhu S,Wang W,Yi H,Du X,Nie X,He Y,Song H,Miao Q,Wang L,Li G

更新日期：2015-04-01 00:00:00

abstract：:Background The relationship between renal disease and cardiovascular disease (CVD) is currently known as cardiorenal syndrome. Indoxyl sulfate (IS) is one of the uremic toxins that accelerates the progression of cardiorenal syndrome. This report presents a new method for measuring IS in a simpler way. Methods We evalu...

journal_title：Clinical chemistry and laboratory medicine

authors： Fushimi Y,Tatebe J,Okuda Y,Ishii T,Ujiie S,Morita T

更新日期：2019-10-25 00:00:00

abstract：BACKGROUND:Cardiac troponin T (cTnT) has been reported to be a predictor of stroke outcome. We hypothesized that the high-sensitivity cTnT (hs-cTnT) assay is superior to its previous assay generation for stroke outcome prediction. METHODS:cTnT was measured on emergency department admission in 60 consecutive patients (...

journal_title：Clinical chemistry and laboratory medicine

authors： Furtner M,Ploner T,Hammerer-Lercher A,Pechlaner R,Mair J

更新日期：2012-11-01 00:00:00

abstract：:Increased expression of sialyl Lewis X or A antigens on metastatic cancer cells leads to their selectin-mediated extravasation. Profound fucosylation of the serum microenvironment may be a factor that interrupts adhesion and influences the formation of metastases. In this study we quantitatively analyzed fucosylation ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kossowska B,Ferens-Sieczkowska M,Gancarz R,Passowicz-Muszyńska E,Jankowska R

更新日期：2005-01-01 00:00:00

abstract：:The aim of this study was to clarify the effects of anti-dsDNA antibodies on the titer and the nuclear staining pattern(s) in a fluorescent antinuclear antibody (FANA) assay using HEp-2 cells. Anti-dsDNA derived from 14 patients with systemic lupus erythematosus (SLE) was individually affinity-purified. The anti-dsDNA...

journal_title：Clinical chemistry and laboratory medicine

authors： Suzuki K,Kawamura M,Mineo M,Shinohara T,Kataharada K,Okada M,Takada K,Miyawaki S,Ohsuzu F

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Biological variation (BV) data enable assessment of the significance of changes in serial measurements observed within a subject and are used to set analytical quality specifications. This data is available in a database held in Westgard website (http://www.westgard.com/biodatabase1.htm). Some limitations of...

journal_title：Clinical chemistry and laboratory medicine

authors： Carobene A

更新日期：2015-05-01 00:00:00

abstract：:A body of evidence has been accumulated to demonstrate that current practice is not sufficiently safe for several stages of central laboratory testing. In particular, while analytical and perianalytical steps that take place within the laboratory are subjected to quality control procedures, this is not the case for se...

journal_title：Clinical chemistry and laboratory medicine

authors： Kay J

更新日期：2006-01-01 00:00:00

abstract：:Classical genetic studies involving the analysis of pedigrees and recurrence risk within families have defined the extent to which genetic factors contribute to the aetiology of multiple sclerosis. Limited progress has been made in identifying the number and topography of genetic loci contributing to susceptibility th...

journal_title：Clinical chemistry and laboratory medicine

authors： Compston A

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Serum immunoglobulin free light chains (FLC) are secreted into circulation by plasma cells as a by-product of immunoglobulin production. In a healthy individual the population of FLC is polyclonal as no single cell is secreting more FLC than the total immunoglobulin secreting cell population. In a person wit...

journal_title：Clinical chemistry and laboratory medicine

authors： Barnidge DR,Dispenzieri A,Merlini G,Katzmann JA,Murray DL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Transition from communications (abstracts) of an Argentinean congress and their publication as full papers was analyzed. No similar report was found for clinical laboratory in Latin America. METHODS:A total of 388 communications from five congresses were identified, and searches were performed on the intern...

journal_title：Clinical chemistry and laboratory medicine

authors： Martínez AM,Fink NE

更新日期：2008-01-01 00:00:00

abstract：:We developed sensitive assay methods for autoantibodies recognizing the citrullinated synthetic peptides derived from type I and type II collagens in patients with rheumatoid arthritis (RA). These peptides were tested with the chemiluminescence method (Nichols Advantage System). In 44 RA patients out of 120, the sera ...

journal_title：Clinical chemistry and laboratory medicine

authors： Koivula MK,Ramberg J,Aman S,Karjalainen A,Hakala M,Risteli J

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis is a crucial process in tissue remodeling during growth, both in the embryo and the adult. In our study we concentrated on the direct effect of beta-carotene on human umbilical cord originating from endothelial progenitor cells (EPCs). beta-Carotene uptake by EPCs was measured using a HPLC method. The det...

journal_title：Clinical chemistry and laboratory medicine

authors： Kieć-Wilk B,Polus A,Grzybowska J,Mikołajczyk M,Hartwich J,Pryjma J,Skrzeczyńska J,Dembińska-Kieć A

更新日期：2005-01-01 00:00:00