An enzyme linked immunosorbent assay (ELISA) for the determination of the human haptoglobin phenotype.

abstract：BACKGROUND:Recent studies have suggested that omentin-1 plays a critical role in the development of cardiovascular disease. However, reported findings are inconsistent, and no study has evaluated the association between omentin-1 levels and a poor functional outcome after ischemic stroke onset. METHODS:A total of 266 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Xu T,Zuo P,Wang Y,Gao Z,Ke K

更新日期：2018-01-26 00:00:00

abstract：:Surface-enhanced laser desorption time of flight mass spectrometry (SELDI-TOF-MS) is an important proteomic technology that is immediately available for the high throughput analysis of complex protein samples. Over the last few years, several studies have demonstrated that comparative protein profiling using SELDI-TOF...

journal_title：Clinical chemistry and laboratory medicine

authors： Kiehntopf M,Siegmund R,Deufel T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:In analogy with other areas of laboratory diagnostics, the pre-analytical phase is the leading source of variability also in urinalysis. We carried out a multicentric study for comparing results obtained from first-voided and mid-stream urine samples. METHODS:Each of the six hospital-based clinical laborato...

journal_title：Clinical chemistry and laboratory medicine

authors： Manoni F,Gessoni G,Alessio MG,Caleffi A,Saccani G,Silvestri MG,Poz D,Ercolin M,Tinello A,Valverde S,Ottomano C,Lippi G

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:With patients referred to emergency departments (EDs) for acute dyspnea, emergency physicians should consider all possible diagnoses and assess patients' risk stratification. Copeptin has been shown to have prognostic power for subsequent events, such as death and rehospitalization in patients admitted for d...

journal_title：Clinical chemistry and laboratory medicine

authors： Vetrone F,Santarelli S,Russo V,Lalle I,De Berardinis B,Magrini L,Di Stasio E,Salerno G,Cardelli P,Piccoli A,Codognotto M,Mion MM,Plebani M,Vettore G,Castello LM,Avanzi GC,Di Somma S

更新日期：2014-10-01 00:00:00

abstract：:The aim of this work was to assess the diagnostic value of anti-CCP-3 and anti-CCP-2 for the diagnosis of rheumatoid arthritis (RA) and determine whether anti-CCP-3 more accurately identifies patients with rheumatoid arthritis than anti-CCP-2. PubMed and CNKI databases were searched for studies published in English an...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhang WC,Wu H,Chen WX

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:As ABO blood type influences the plasma level of coagulation factor VIII (FVIII), it likely also affects activated partial thromboplastin time (aPTT) and thrombin generation assay (TGA) values. Here, we aimed to investigate the effect of ABO type on the normal values of three global coagulation assays: proth...

journal_title：Clinical chemistry and laboratory medicine

authors： Choi Q,Kim JE,Kim SY,Han KS,Kim HK

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:We aimed to investigate the prevalence of undiagnosed abnormal glucose regulation (AGR, including diabetes and prediabetes) in patients undergoing coronary angiography (CAG) by using both glycated hemoglobin (HbA1c) and oral glucose tolerance test (OGTT) to screen, and to compare the performance of fasting p...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang JS,Lee IT,Lee WJ,Lin SY,Fu CP,Lee WL,Liang KW,Sheu WH

更新日期：2015-08-01 00:00:00

abstract：Objectives:Monoclonal immunoglobulins can cause interference in many laboratory analyses. During a 4 month period we observed seven patients with monoclonal disease and falsely extremely elevated 25-hydroxyvitamin D (25(OH)D) results above 160 ng/mL (>400 nmol/L) measured using an immunoassay from Abbott Diagnostics. B...

journal_title：Clinical chemistry and laboratory medicine

authors： Hager HB,Bolstad N,Warren DJ,Ness MV,Seierstad B,Lindberg M

更新日期：2020-10-29 00:00:00

abstract：:Increased expression of sialyl Lewis X or A antigens on metastatic cancer cells leads to their selectin-mediated extravasation. Profound fucosylation of the serum microenvironment may be a factor that interrupts adhesion and influences the formation of metastases. In this study we quantitatively analyzed fucosylation ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kossowska B,Ferens-Sieczkowska M,Gancarz R,Passowicz-Muszyńska E,Jankowska R

更新日期：2005-01-01 00:00:00

abstract：:The aim of this multicenter study was to evaluate the technical and clinical performance of the Elecsys S100 electrochemiluminescence immunoassay and to assess its utility as a tumor marker in patients with malignant melanoma. Imprecision studies yielded within-run coefficients of variation (CVs) of 0.7-2.0% and betwe...

journal_title：Clinical chemistry and laboratory medicine

authors： Alber B,Hein R,Garbe C,Caroli U,Luppa PB

更新日期：2005-01-01 00:00:00

abstract：:Iron status in man is influenced by environmental and genetic factors. The molecular variation of haptoglobin is one of the genetic factors influencing iron status in Caucasians. Differences in iron metabolism between blacks and whites have been reported. We wanted to investigate the effect of haptoglobin polymorphism...

journal_title：Clinical chemistry and laboratory medicine

authors： Kasvosve I,Gordeuk VR,Delanghe JR,Gomo ZA,Gangaidzo IT,Khumalo H,Moyo VM,Saungweme T,Mvundura E,Boelaert JR

更新日期：2002-08-01 00:00:00

abstract：:Two reverse transcription-polymerase chain reaction methods to detect the AML1/ETO rearrangement in the M2 subtype of acute myeloid leukaemia those of Downing et al. (Blood 1993; 81: 2860-5) and Satake et al. (Br J Haematol 1995; 91: 892-8) were evaluated. Bone marrow samples, one at diagnosis and two in complete remi...

journal_title：Clinical chemistry and laboratory medicine

authors： Barragán E,Bonanad S,López JA,Bolufer P,Sanz MA

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Cardiac troponins are considered the cornerstone for risk stratification and diagnosis of patients with acute coronary syndrome (ACS). Following Clinical Laboratory Standards Institute (CLSI) guidelines, we assessed the analytical performances of the Pathfast (Mitsubishi, Japan) cTnI method. METHODS:We eval...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Serio F,Caputo M,Zaninotto M,Ottomano C,Plebani M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important. METHODS:An inductively coupled plasma mass spectrometry (ICP-MS) metho...

journal_title：Clinical chemistry and laboratory medicine

authors： Yan Y,Han B,Zeng J,Zhou W,Zhang T,Zhang J,Chen W,Zhang C

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:Cost-impact models have indicated that in the USA, the use of antibiotic stewardship protocols based on procalcitonin (PCT) levels for patients with suspected acute respiratory tract infection results in cost savings. Our objective was to assess the cost impact of adopting PCT testing among patients with acu...

journal_title：Clinical chemistry and laboratory medicine

authors： Stojanovic I,Schneider JE,Wei L,Hong Z,Keane C,Schuetz P

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:EML4-ALK fusion oncogene has emerged as a novel molecular target in non-small cell lung cancer (NSCLC). Although break-apart fluorescent in situ hybridization (FISH) is the standard method for diagnosis, it is expensive, not readily available and sometimes difficult to interpret. In addition, ALK immunohisto...

journal_title：Clinical chemistry and laboratory medicine

authors： Rho JK,Lee H,Park CS,Choi CM,Lee JC

更新日期：2013-09-01 00:00:00

abstract：:Historical research on the concept of normality, its roots and its development show that this concept has its sources in very different areas of scientific and medical thinking. Of great importance were: (i) a new theory of disease arising early in the 19th century supposing a continuous change from the healthy to the...

journal_title：Clinical chemistry and laboratory medicine

authors： Büttner J

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The biochemical determination of cardiac natriuretic peptides, primarily brain natriuretic peptide (BNP) and the amino-terminal fragment of its pro-hormone proBNP (NT-proBNP), are reliable tools for diagnosing cardiac disease, establishing prognosis and evaluating the effectiveness of treatment. These biomar...

journal_title：Clinical chemistry and laboratory medicine

authors： Zaninotto M,Mion MM,Di Serio F,Caputo M,Ottomano C,Plebani M

更新日期：2010-07-01 00:00:00

abstract：:Background Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers advantages over immunoassay due to its increased specificity and ability to multiplex metabolites within a single run. Wide scale adoption of LC-MS/MS in routine clinical laboratories is restricted in part due to the high level of technical ex...

journal_title：Clinical chemistry and laboratory medicine

authors： Benton SC,Tetteh GK,Needham SJ,Mücke J,Sheppard L,Alderson S,Ruppen C,Curti M,Redondo M,Milan AM

更新日期：2020-06-25 00:00:00

abstract：:Total prostate-specific antigen (PSA) and complexed PSA were determined in venous blood from 12 patients with prostate cancer before and after radical prostatectomy by using Immuno 1 PSA assays. The elimination kinetics of complexed PSA were compared with that of total PSA. Nearly constant concentrations of complexed ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stephan C,Jung K,Brux B,Lein M,Sinha P,Schnorr D,Loening SA

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Low levels of plasma homocysteine have been found in children and adult populations living in Burkina Faso in association with a low prevalence of coronary heart disease. METHODS:Based on this finding, the levels of plasma homocysteine and other thiols (cysteine, cysteinylglycine, glutathione) in postmenopa...

journal_title：Clinical chemistry and laboratory medicine

authors： Chillemi R,Simpore J,Persichilli S,Minucci A,D'Agata A,Musumeci S

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:This paper describes the evolution, structure, operation and some outcomes of the Brazilian Laboratory Indicators Program created by the Brazilian Society of Clinical Pathology/Laboratory Medicine (Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial, or SBPC/ML), in partnership with ControlLab, a...

journal_title：Clinical chemistry and laboratory medicine

authors： Shcolnik W,de Oliveira CA,de São José AS,de Oliveira Galoro CA,Plebani M,Burnett D

更新日期：2012-11-01 00:00:00

abstract：:Prolidases I and II were highly purified from human erythrocytes. The effects of various amino acids, MnCl2 and mercaptoethanol, on these two enzymes were investigated. Normal prolidase II was very labile in the absence of MnCl2 or mercaptoethanol. The activity of prolidase II was maintained at about 76% by pre-incuba...

journal_title：Clinical chemistry and laboratory medicine

authors： Nakayama K,Awata S,Zhang J,Kaba H,Manabe M,Kodama H

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:When performed erroneously, the venous blood specimen collection (VBSC) practice steps patient identification, test request management and test tube labeling are at high risk to jeopardize patient safety. VBSC educational programs with the intention to minimize risk of harm to patients are therefore needed. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Willman B,Grankvist K,Bölenius K

更新日期：2018-10-25 00:00:00

abstract：:A questionnaire to assess knowledge of the expected elevation in serum K measurement with different grades of hemolysis was administered to medical technologists working in biochemistry laboratories, hospital physicians and nurses. The questions involved different grades of hemolysis (mild, 1.0, moderate, 2.5 and seve...

journal_title：Clinical chemistry and laboratory medicine

authors： Hawkins RC

更新日期：2005-01-01 00:00:00

abstract：:This review evaluates the role of platelets in bleeding risk among patients with hematological disease and thrombocytopenia. Platelets are pivotal in primary hemostasis, and possess non-hemostatic properties involved in angiogenesis, tissue repair, inflammation and metastatis. Also, platelets safeguard vascular integr...

journal_title：Clinical chemistry and laboratory medicine

authors： Vinholt PJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:Certain genetic polymorphisms can lead to differences in immunity function, resulting in different clinical outcomes for hepatitis B virus (HBV) patients. The aim of this study was to investigate the association between apolipoprotein E (ApoE) gene polymorphisms and HBV infection status in northern Chinese i...

journal_title：Clinical chemistry and laboratory medicine

authors： Yin Z,Xiong C,Wang Y,Zhou X,Yan SK

更新日期：2010-12-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is formed by methylation of arginine residues in proteins and released after proteolysis. In this reaction, S-adenosylmethionine is methyldonor and S-adenosylhomocysteine the demethylated product. ADMA and homocysteine are thus bioch...

journal_title：Clinical chemistry and laboratory medicine

authors： van Guldener C,Nanayakkara PW,Stehouwer CD

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Plasma non-esterified (free) fatty acid concentrations rise as a consequence of stimulated endogenous lipolysis and are inversely related to the plasma magnesium concentration when plasma adrenaline concentration is increased. The aim of the study was to test whether high plasma non-esterified fatty acid conc...

journal_title：Clinical chemistry and laboratory medicine

authors： de Valk HW,Bianchi R,van Rijn HJ,Erkelens DW

更新日期：1998-02-01 00:00:00