Abstract:
BACKGROUND:As ABO blood type influences the plasma level of coagulation factor VIII (FVIII), it likely also affects activated partial thromboplastin time (aPTT) and thrombin generation assay (TGA) values. Here, we aimed to investigate the effect of ABO type on the normal values of three global coagulation assays: prothrombin time (PT), aPTT, and TGA. METHODS:PT, aPTT, TGA [1 or 5 pmol/L tissue factor (TF)], coagulation factors, anticoagulation factors, and ABO type were measured in 200 healthy adults. RESULTS:aPTT was significantly prolonged in those with type O compared with those with type non-O, whereas PT was not significantly different between those with type O and type non-O. The time to peak induced by 5 pmol/L TF was significantly prolonged, and the peak thrombin level was decreased in those with type O compared with those with type non-O. FVIII was a major contributor to the ABO-specific reference range of aPTT, 5 pmol/L TF-induced time to peak, and peak thrombin level. CONCLUSIONS:The reference ranges of aPTT and TGA (time to peak and peak thrombin level) differed by ABO type. FVIII level is considered a major contributor to ABO type-specific differences with respect to aPTT and TGA.
journal_name
Clin Chem Lab Medjournal_title
Clinical chemistry and laboratory medicineauthors
Choi Q,Kim JE,Kim SY,Han KS,Kim HKdoi
10.1515/cclm-2014-0909subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1425-32issue
9eissn
1434-6621issn
1437-4331pii
/j/cclm.ahead-of-print/cclm-2014-0909/cclm-2014-09journal_volume
53pub_type
杂志文章abstract:BACKGROUND:We verified the analytical performance of strip-based handheld glucose meters (GM) for prescription use, in a comparative split-sample protocol using blood gas samples from a surgical intensive care unit (ICU). METHODS:Freestyle Precision Pro (Abbott), StatStrip Connectivity Meter (Nova), ACCU-CHEK Inform I...
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doi:10.1515/CCLM.2008.288
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journal_title:Clinical chemistry and laboratory medicine
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doi:10.1515/CCLM.2001.136
更新日期:2001-09-01 00:00:00
abstract::Background This study aimed to investigate the correlation between glucose fluctuation from self-monitored blood glucose (SMBG) and the major adverse cardiac events (MACE) in diabetic patients with acute coronary syndrome (ACS) during a 6-month follow-up period using the WeChat application. Methods From November 2016 ...
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更新日期:2001-06-01 00:00:00
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更新日期:2001-12-01 00:00:00