Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure.

abstract：BACKGROUND:Point of care (POC) assays for cardiac troponins I or T (cTnI or cTnT) may accelerate the diagnosis of patients with suspected acute coronary syndrome (ACS). However, their clinical utility according to the 0 h/3 h algorithm recommended by the European Society of Cardiology (ESC) for non-ST elevation myocard...

journal_title：Clinical chemistry and laboratory medicine

authors： Suh D,Keller DI,Hof D,von Eckardstein A,Gawinecka J

更新日期：2018-03-28 00:00:00

abstract：:Many limitations and conflicting results have cast serious doubts on the validity of cerebrospinal fluid tau and Abeta42 levels for the biological diagnosis of Alzheimer's disease, particularly extreme variations of the reference limits found by unrelated groups as a consequence of different reference populations used...

journal_title：Clinical chemistry and laboratory medicine

authors： Burkhard PR,Fournier R,Mermillod B,Krause KH,Bouras C,Irminger I

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Angiotensin II is produced primarily by angiotensin I-converting enzyme (ACE) within atherosclerotic lesions and ACE level in plaques correlates with the severity of vessel wall damage. Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of a...

journal_title：Clinical chemistry and laboratory medicine

authors： Niemiec P,Zak I,Wita K

更新日期：2008-01-01 00:00:00

abstract：:Since serum and plasma D-dimer concentrations correlate very well, we evaluated the comparability of other haemostasis activation markers in plasma and serum. Prothrombin fragment F1+2, fibrin monomer and D-dimer concentrations were measured with commercially available immunoassays in serum and plasma. Serum to plasma...

journal_title：Clinical chemistry and laboratory medicine

authors： Korte W,Riesen WF

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Despite remarkable advances in technology and laboratory automation, results of laboratory testing still suffer from a high degree of preanalytical variability. Although there is no definitive evidence, the use of small-gauge needles for venipuncture is usually discouraged to reduce the chance of producing u...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Salvagno GL,Montagnana M,Brocco G,Cesare Guidi G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Autoantibodies against β1-adrenergic receptors (β1AR) that stimulate cardiac cAMP-production play a causal role in the pathogenesis of human heart failure. Patients can be subjected to specific therapies, if the presence of potentially cardio-noxious β1AR-autoantibodies is reliably diagnosed. This requires a...

journal_title：Clinical chemistry and laboratory medicine

authors： Bornholz B,Benninghaus T,Reinke Y,Felix SB,Roggenbuck D,Jahns-Boivin V,Jahns R,Boege F

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Quantification of glycated hemoglobin (HbA1c) is a challenge in patients with hemoglobin (Hb) variants. We evaluated the impact of various Hb variants on five routine HbA1c assays by comparing with the IFCC reference measurement procedure (RMP). METHODS:Whole blood samples showing warning flags or no result...

journal_title：Clinical chemistry and laboratory medicine

authors： Yun YM,Ji M,Ko DH,Chun S,Kwon GC,Lee K,Song SH,Seong MW,Park SS,Song J

更新日期：2017-07-26 00:00:00

abstract：:The clinical usefulness of C-reactive protein (CRP) and of transthyretin (TTR) for the early diagnosis and follow-up of infection after an open fracture was prospectively investigated (cohort A). It was complemented by a retrospective study of trauma patients admitted to an intensive care unit (cohort B). Serial deter...

journal_title：Clinical chemistry and laboratory medicine

authors： Férard G,Gaudias J,Bourguignat A,Ingenbleek Y

更新日期：2002-12-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a potent inhibitor of nitric oxide synthase and is regarded as a novel risk factor for cardiovascular disease. The metabolic pathways of ADMA and homocysteine are strongly intertwined. First, during synthesis of ADMA, two equivalents of homocysteine are formed. Second, homocystein...

journal_title：Clinical chemistry and laboratory medicine

authors： Teerlink T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Reference laboratories providing reference services recognized by the Joint Committee for Traceability in Laboratory Medicine (JCTLM) must be accredited as calibration laboratories according to ISO 17025 and ISO 15195. These standards require laboratories to establish an uncertainty budget, in which the unce...

journal_title：Clinical chemistry and laboratory medicine

authors： Rami L,Canalias F

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The Intermountain Mortality Risk Score (IMRS), a sex-specific mortality-prediction metric, has proven to be effective in various populations. IMRS is comprised of the complete blood count (CBC), basic metabolic panel (BMP), and age. Whether the addition of factors from the comprehensive metabolic panel (CMP)...

journal_title：Clinical chemistry and laboratory medicine

authors： May HT,Anderson JL,Muhlestein JB,Lappé DL,Ronnow BS,Horne BD

更新日期：2016-10-01 00:00:00

abstract：:Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic...

journal_title：Clinical chemistry and laboratory medicine

authors： Hultberg B,Jensen E,Dehlin O,Hagberg B,Samuelsson G,Svensson T

更新日期：1999-10-01 00:00:00

abstract：:Progression of atherosclerosis is currently believed to involve interactions between leukocytes and vascular endothelium. Epidemiological risk factors for atherosclerosis such as hypertension and smoking are known to cause endothelial dysfunction, which is an early event in the atherosclerotic process; they also may b...

journal_title：Clinical chemistry and laboratory medicine

authors： Mazzone A,Cusa C,Mazzucchelli I,Vezzoli M,Ottini E,Ghio S,Tossini G,Pacifici R,Zuccaro P

更新日期：2001-09-01 00:00:00

abstract：:Automation is considered one of the most important breakthroughs in the recent history of laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers performing different types of tests on different sample matrices are physically integrated as modular systems or physically connected by asse...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Da Rin G

更新日期：2019-05-27 00:00:00

abstract：:Quality in diagnostic testing represents a key target of laboratory medicine, for which an assurance around the quality of testing is expected from all involved in the process. Laboratories attempt to assure the quality of their testing by various processes, but especially by performance of internal quality control an...

journal_title：Clinical chemistry and laboratory medicine

authors： Favaloro EJ,Jennings I,Olson J,Van Cott EM,Bonar R,Gosselin R,Meijer P

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Laboratory reference intervals are not necessarily reflecting the range in the background population. This study compared creatine kinase (CK) reference intervals calculated from a large sample from a Norwegian population with those elaborated by the Nordic Reference Interval Project (NORIP). It also assesse...

journal_title：Clinical chemistry and laboratory medicine

authors： Lilleng H,Johnsen SH,Wilsgaard T,Bekkelund SI

更新日期：2011-11-10 00:00:00

abstract：:Glycosylation is among the most important post-translational modifications for proteins and is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50%-70% of proteins in circulation are glycosylated, and the "sweet attachments" have versatile structural and functional implications. Both ...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang M,Zhu J,Lubman DM,Gao C

更新日期：2019-03-26 00:00:00

abstract：PURPOSE:DNA strand breaks are believed to induce carcinogenesis. This study was conducted to analyze induction and repair of irradiation- and chemotherapy-related strand breaks in vitro. METHODS:Friend Leukemia cells were exposed to irradiation and various chemotherapeutic agents at different doses and concentrations....

journal_title：Clinical chemistry and laboratory medicine

authors： Froelich JJ,Schneller FR,Zahn RK

更新日期：1999-04-01 00:00:00

abstract：:Betaine serves as a methyl donor in a reaction converting homocysteine to methionine, catalysed by the enzyme betaine-homocysteine methyltransferase. It has been used for years to lower the concentration of plasma total homocysteine (tHcy) in patients with homocystinuria, and has recently been shown to reduce fasting ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ueland PM,Holm PI,Hustad S

更新日期：2005-01-01 00:00:00

abstract：:Background The accurate and precise measurement of triglycerides is important due to the adverse effects associated with hypertriglyceridaemia. Most laboratory methods are based on enzymatic hydrolysis of triglycerides with measurement of the total glycerol. An elevated free glycerol concentration may result in overes...

journal_title：Clinical chemistry and laboratory medicine

authors： van Heerden C,Magwete A,Mabuza D

更新日期：2020-07-28 00:00:00

abstract：:On May 28-29, 2009, a number of medical laboratory opinion leaders, pathologists and biochemists met in Sitges, Spain to discuss issues of interest to medical laboratory professionals. The meeting was sponsored by Bio-Rad Laboratories Inc. (Hercules, CA). Over 40 persons representing Austria, Belgium, Czech Republic, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Burnett D,Ceriotti F,Cooper G,Parvin C,Plebani M,Westgard J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein A-I gene (APOA1) polymorphisms have been associated with variations in serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol. We have investigated whether APOA1 common variants are also associated with variations in basal triglyceride serum concentrations and resp...

journal_title：Clinical chemistry and laboratory medicine

authors： Sorkin SC,Forestiero FJ,Hirata MH,Guzmán EC,Cavalli SA,Bertolami MC,Salazar LA,Hirata RD

更新日期：2005-01-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance during pregnancy. In Denmark the health service offers selective screening for GDM, i.e., admission to an oral glucose tolerance test (OGTT) after pre-screening with interview for clinical risk factors for GDM, two capillary fasting blood gluco...

journal_title：Clinical chemistry and laboratory medicine

authors： Schytte T,Jørgensen LG,Brandslund I,Petersen PH,Andersen B

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Cardiac biomarkers, including cardiac troponin-I (cTn-I) and N-terminal pro brain natriuretic peptide (NT-proBNP) have been associated with poor outcome in hemodialysis (HD) patients. The present study was designed to evaluate these biomarkers as biological risk factors for early and late mortality in HD pat...

journal_title：Clinical chemistry and laboratory medicine

authors： Bargnoux AS,Morena M,Jaussent I,Maurice F,Chalabi L,Leray-Moragues H,Terrier N,Dupuy AM,Badiou S,Canaud B,Cristol JP

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validat...

journal_title：Clinical chemistry and laboratory medicine

authors： Badrnya S,Doherty T,Richardson C,McConnell RI,Lamont JV,Veitinger M,FitzGerald SP,Zellner M,Umlauf E

更新日期：2018-04-25 00:00:00

abstract：BACKGROUND:Interpretation of alkaline phosphatase activity in children is challenging due to extensive changes with growth and puberty leading to distinct sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics and seem reasonable for an analyt...

journal_title：Clinical chemistry and laboratory medicine

authors： Zierk J,Arzideh F,Haeckel R,Cario H,Frühwald MC,Groß HJ,Gscheidmeier T,Hoffmann R,Krebs A,Lichtinghagen R,Neumann M,Ruf HG,Steigerwald U,Streichert T,Rascher W,Metzler M,Rauh M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Genes correlated with nicotine may be important in obesity because of the role of nicotine in food intake. METHODS:To determine if single nucleotide polymorphisms (SNPs) in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) are associated with overweight/obesity, 156 non-obese and 20...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim J

更新日期：2008-01-01 00:00:00

abstract：:Classical genetic studies involving the analysis of pedigrees and recurrence risk within families have defined the extent to which genetic factors contribute to the aetiology of multiple sclerosis. Limited progress has been made in identifying the number and topography of genetic loci contributing to susceptibility th...

journal_title：Clinical chemistry and laboratory medicine

authors： Compston A

更新日期：2000-02-01 00:00:00

abstract：:Metabolic conversion of homocysteine (Hcy) to a chemically reactive metabolite, Hcy-thiolactone, catalyzed by methionyl-tRNA synthetase is the first step in a pathway that is suggested to contribute to Hcy toxicity in humans. The accumulation of Hcy-thiolactone is detrimental because of its intrinsic ability to modify...

journal_title：Clinical chemistry and laboratory medicine

authors： Jakubowski H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Fatty acid metabolites play a key role in numerous physiological and pathological processes. A rapid liquid chromatography-mass spectrometry assay for the simultaneous determination of prostanoids, isoprostane and lipoxygenase (LOX) derived fatty acid metabolites in a small biological sample of only 20 micro...

journal_title：Clinical chemistry and laboratory medicine

authors： Unterwurzacher I,Koal T,Bonn GK,Weinberger KM,Ramsay SL

更新日期：2008-01-01 00:00:00