Urinary iodine concentrations of pregnant women in Ukraine.

abstract：:We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique. Insulin action, as evaluated by glu...

journal_title：Clinical chemistry and laboratory medicine

authors： Stanická S,Vondra K,Pelikánová T,Vlcek P,Hill M,Zamrazil V

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The IFCC Task Force on Clinical Applications of Cardiac Biomarkers suggests comparing several contemporary sensitive troponin assays in the same, sufficiently large reference population. METHODS:Three contemporary sensitive assays were used to measure troponin I concentration in samples from a uniquely larg...

journal_title：Clinical chemistry and laboratory medicine

authors： Petersmann A,Ittermann T,Fries C,Lubenow N,Kohlmann T,Kallner A,Greinacher A,Nauck M

更新日期：2013-11-01 00:00:00

abstract：:Evidence of the acute lack of interchangeable laboratory results and consensus in current practice among clinical laboratories has underpinned greater attention to standardization and harmonization projects. Although the focus is mainly on the standardization of measurement procedures, the scope of harmonization goes ...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analy...

journal_title：Clinical chemistry and laboratory medicine

authors： Cangemi G,Storti S,Cantinotti M,Fortunato A,Emdin M,Bruschettini M,Bugnone D,Melioli G,Clerico A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Ebola virus, an enveloped virus, is the cause of the largest and most complex Ebola virus disease (EVD) outbreak in West Africa. Blood or body fluids of an infected person may represent a biohazard to laboratory workers. Laboratory tests of virus containing specimens should be conducted in referral centres a...

journal_title：Clinical chemistry and laboratory medicine

authors： Tempestilli M,Pucci L,Notari S,Di Caro A,Castilletti C,Rivelli MR,Agrati C,Pucillo LP

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The possible effects of the uncoupling protein-1 (UCP-1) gene -3826A/G polymorphism on hypertension (HT) have yet to be elucidated. METHODS:A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the -3826A/G ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kotani K,Sakane N,Saiga K,Tsuzaki K,Shimohiro H,Tabata M,Kurozawa Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recently published data identified bone-specific alkaline phosphatase (BALP) as a good marker of bone formation in different bone diseases and osteoporosis. Two methods are available for BALP determination: one measures enzyme activity, the other its mass concentration. We compared results for BALP activity ...

journal_title：Clinical chemistry and laboratory medicine

authors： Avbersek-Luznik I,Gmeiner Stopar T,Marc J

更新日期：2007-01-01 00:00:00

abstract：:Brain natriuretic peptide is proposed as a biochemical marker which could provide a useful screening test to select patients for further cardiac investigations in heart failure. The applicability of such a biochemical test in clinics, hospital wards, and clinical laboratories is dependent on its ease of use and on the...

journal_title：Clinical chemistry and laboratory medicine

authors： Gobinet-Georges A,Valli N,Filliatre H,Dubernet MF,Dedeystere O,Bordenave L

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Blood alcohol determination plays an important role in laboratory medicine and forensic medicine. Nowadays, many methods are being used for alcohol measurement, but these methods are time-consuming and complex to perform laborious sample pre-treatment. The disposable amperometric biosensor, due to its portab...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo P,Xie G,Liu Y,Xu H,Deng S,Song F

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mo...

journal_title：Clinical chemistry and laboratory medicine

authors： Kurt YG,Cayci T,Onguru P,Akgul EO,Yaman H,Aydin I,Bodur H,Turker T,Kurt I,Cevik MA,Erbil MK

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Risk prediction algorithms for coronary heart disease (CHD) are recommended for clinical use. However, their predictive ability remains modest and the inclusion of genetic risk may improve their performance. METHODS:QRISK2 was used to assess CHD risk using conventional risk factors (CRFs). The performance o...

journal_title：Clinical chemistry and laboratory medicine

authors： Beaney KE,Cooper JA,Drenos F,Humphries SE

更新日期：2017-08-28 00:00:00

abstract：:Automation is considered one of the most important breakthroughs in the recent history of laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers performing different types of tests on different sample matrices are physically integrated as modular systems or physically connected by asse...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Da Rin G

更新日期：2019-05-27 00:00:00

abstract：BACKGROUND:The knowledge of physiological fluctuation and variation of even commonly used biochemical quantities in extreme age groups and during development is sparse. This challenges the clinical interpretation and utility of laboratory tests in these age groups. To explore the utility of hospital laboratory data as ...

journal_title：Clinical chemistry and laboratory medicine

authors： Søeby K,Jensen PB,Werge T,Sørensen S

更新日期：2015-09-01 00:00:00

abstract：:We evaluated the analytical performance of the Immulite 2000 immunoassay analyzer (Diagnostic Products Corporation, Los Angeles, USA) based on a new detection technology, electrochemical luminescence. The evaluated analytes were thyrotropin, triiodothyronine, free thyroxine, follitropin, lutropin, prolactin, cortisol,...

journal_title：Clinical chemistry and laboratory medicine

authors： Tello FL,Hernández DM

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:The handling of cerebrospinal fluid (CSF) affects the biomarker quantification used to diagnose Alzheimer's disease (AD). Only specialized centers can test for AD markers. The precise timing and freezing is required to correctly measure these biomarkers. Therefore, the effects of CSF storage temperature and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Klener J,Hofbauerová K,Bartoš A,Ríčný J,Rípová D,Kopecký V

更新日期：2014-05-01 00:00:00

abstract：:Cryoglobulins are proteins that precipitate at temperatures below 37 degrees C. Cold-induced precipitation of proteins may occur in vivo secondary to several important diseases, and lead to pathological manifestations involving different organs. Cryoprecipitation may be observed in vitro by exposing serum samples, sup...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Stasio E,Bizzarri P,Bove M,Casato M,Giardina B,Fiorilli M,Galtieri A,Pucillo LP

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Mutations in BRCA1 and BRCA2 genes are associated with family predisposition to breast and ovarian cancer. Novel screening methods are required for efficient and rapid detection of sequence variants in cancer patients and their family members. METHODS:The screening for variants in the breast and ovarian can...

journal_title：Clinical chemistry and laboratory medicine

authors： Cvok ML,Cretnik M,Musani V,Ozretic P,Levanat S

更新日期：2008-01-01 00:00:00

abstract：Objectives:Colorectal cancer (CRC) screening using stool samples is now in routine use where tumor DNA methylation analysis for leading markers such as NDRG4 and SDC2 is an integral part of the test. However, processing stool samples for reproducible and efficient extraction of human genomic DNA remains a bottleneck fo...

journal_title：Clinical chemistry and laboratory medicine

authors： Jin S,Ye Q,Hong Y,Dai W,Zhang C,Liu W,Guo Y,Zhu D,Zhang Z,Chen S,Wang Y,Li D,Ma W,Yang Z,Li J,Zheng Z,Luan J,Wu X,Jiang F,Xu C,Ding C

更新日期：2020-07-16 00:00:00

abstract：:Background The aim of this study was to evaluate the diagnostic performance of cerebrospinal fluid (CSF) free light chains (FLCs) in the diagnosis of Lyme neuroborreliosis (LNB). Methods Serum and CSF levels of κ- and λ-FLC, albumin and total concentration of immunoglobulin M (IgM) were determined together with CSF ch...

journal_title：Clinical chemistry and laboratory medicine

authors： Tjernberg I,Johansson M,Henningsson AJ

更新日期：2019-11-26 00:00:00

abstract：:This study was designed to test the hypothesis that impaired neutrophil function might contribute to the development of bacterial pneumonia in patients with HIV-infection. Numbers of inflammatory cells and immunoglobulin G Fcgamma receptor (IgG FcgammaR) I, II, III levels were investigated in bronchoalveolar lavage (B...

journal_title：Clinical chemistry and laboratory medicine

authors： Armbruster C,Krugluger W,Huber M,Stephan K

更新日期：2004-02-01 00:00:00

abstract：:Serum concentration of carbohydrate 19-9 antigen (CA 19-9), a sensitive marker of pancreatic cancer and cholangiocarcinoma, increases in a variety of liver diseases due to higher production and release by bile duct cells. Biliary epithelial cells are primarily affected in liver disease associated with cystic fibrosis ...

journal_title：Clinical chemistry and laboratory medicine

authors： Bettinardi N,Felicetta I,Tomasi PA,Colombo C

更新日期：2003-03-01 00:00:00

abstract：:Background Quantification of plasma amino acids is key to the diagnosis of inherited defects of amino acid synthesis, catabolism and transport, many of which present as clinical emergencies. The utility of this test is limited by the long analysis time and subsequent inability of laboratories to provide results in rea...

journal_title：Clinical chemistry and laboratory medicine

authors： Carling RS,John K,Churchus R,Turner C,Dalton RN

更新日期：2020-04-28 00:00:00

abstract：:A body of evidence has been accumulated to demonstrate that current practice is not sufficiently safe for several stages of central laboratory testing. In particular, while analytical and perianalytical steps that take place within the laboratory are subjected to quality control procedures, this is not the case for se...

journal_title：Clinical chemistry and laboratory medicine

authors： Kay J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Urinary enzymes, including the brush border enzyme alanine aminopeptidase (AAP), are reliable biomarkers of nephrotoxicity and represent early indicators of tubular damage. The aim of the present study was to develop and validate an automated urinary AAP activity assay. METHODS AND RESULTS:For this purpose,...

journal_title：Clinical chemistry and laboratory medicine

authors： Holdt B,Peters E,Nagel HR,Steiner M

更新日期：2008-01-01 00:00:00

abstract：:Over the past decades, the randomized controlled trial has entered an era of continuous improvement and has gradually become accepted as the most effective way of determining the relative efficacy and toxicity of new therapies because it controls for placebo and time effects. However, even sensitive and properly desig...

journal_title：Clinical chemistry and laboratory medicine

authors： Cleophas TJ

更新日期：1999-11-01 00:00:00

abstract：:Objectives Our recent survey of 44 mass spectrometry laboratories across 17 countries identified variation in internal standard (IS) choice for the measurement of serum/plasma 17α-hydroxyprogesterone (17OHP) by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The choice of IS may contribute to inter-method v...

journal_title：Clinical chemistry and laboratory medicine

authors： Loh TP,Ho CS,Hartmann MF,Zakaria R,Lo CWS,van den Berg S,de Rijke YB,Cooke BR,Hoad K,Graham P,Davies SR,Mackay LG,Wudy SA,Greaves RF

更新日期：2020-09-25 00:00:00

abstract：:Laboratory and radiographic tests are often ordered unnecessarily. This excess testing has financial costs and is a burden on patients. We performed a systematic review to determine the effectiveness interventions to reduce test utilization by physicians. The MEDLINE and EMBASE databases were searched for the years 19...

journal_title：Clinical chemistry and laboratory medicine

authors： Kobewka DM,Ronksley PE,McKay JA,Forster AJ,van Walraven C

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:We assessed whether glycated albumin (GA) is a useful glycemic indicator in diabetic patients with anemia who did not undergo dialysis. METHODS:Hemoglobin A(1c) (HbA(1c)) and GA were simultaneously measured in 370 diabetic subjects who had not undergone dialysis. The relationship between GA and HbA(1c) was ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim S,Min WK,Chun S,Lee W,Park HI

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:In large clinical trials, where RNA cannot be extracted immediately after sampling, preserving RNA in whole blood is a crucial initial step in obtaining robust qPCR data. The current golden standard for RNA preservation is costly and designed for time-consuming column-based RNA-extraction. We investigated th...

journal_title：Clinical chemistry and laboratory medicine

authors： Mærkedahl RB,Frøkiær H,Lauritzen L,Metzdorff SB

更新日期：2015-07-01 00:00:00

abstract：:We estimated the frequencies of phenotype (isoelectric focusing; IEF) vs. genotype (PCR/Hhal) discordance in a sample of an aged population (> 65 years). Both phenotype and genotype techniques have been used in the study of apolipoprotein E (apoE) polymorphism in 125 elderly subjects. The discordance between phenotype...

journal_title：Clinical chemistry and laboratory medicine

authors： Dupuy AM,Badiou S,Ritchie K,Mas E,Descomps B,Cristol JP,Touchon J

更新日期：2001-05-01 00:00:00