Abstract:
:This study was designed to test the hypothesis that impaired neutrophil function might contribute to the development of bacterial pneumonia in patients with HIV-infection. Numbers of inflammatory cells and immunoglobulin G Fcgamma receptor (IgG FcgammaR) I, II, III levels were investigated in bronchoalveolar lavage (BAL) fluid of HIV-seronegative and HIV-infected patients with bacterial pneumonia. The 99 patients were classified into three groups: I: HIV-seronegative and pneumonia (n = 40); II: HIV-infected and pneumonia (n = 19); III: HIV-seronegative with other pulmonary diseases than pneumonia (n = 40). The results of groups I and II, II and III, and I and III were compared. The percentage of alveolar macrophages was significantly lower (group II vs. III: p = 0.005, group I vs. III: p = 0.001), that of neutrophils increased significantly in patients with pneumonia (group II vs. III: p = 0.02, group I vs. III: p = 0.01). Lymphocytes differed only between groups I and III (p = 0.04). Although only the expression of FcgammaRI was significantly higher in HIV-seronegative pneumonia patients compared to those without pneumonia (p = 0.01), the mean expression of all three receptors was lower in the HIV-infected group, with that of FcgammaRI approaching statistical significance. This report provides first evidence that altered FcgammaR expression on BAL neutrophils might contribute to the increased susceptibility of HIV-infected patients to bacterial pneumonia.
journal_name
Clin Chem Lab Medjournal_title
Clinical chemistry and laboratory medicineauthors
Armbruster C,Krugluger W,Huber M,Stephan Kdoi
10.1515/CCLM.2004.035keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
192-7issue
2eissn
1434-6621issn
1437-4331journal_volume
42pub_type
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