Long-term biological variability of galectin-3 after heart transplantation.

Abstract:

BACKGROUND:Galectin-3 is an emerging biomarker of heart failure and of myocardial fibrosis risk. Monitoring of galectin-3 is essential during treatment with galectin-3 inhibitors. The aim of our study was to assess long-term biological variability in a specific group of unhealthy subjects. METHODS:The biological variability of galectin-3 was measured in a group of 44 patients after heart transplantation (HTx). Six samples were taken from each patient during a 12-month period. Galectin-3 was measured with an Abbott Architect automated immunoassay. RESULTS:Intraindividual (CVi) and interindividual (CVg) variabilities were calculated together with the reference change value (RCV), the log-normal RCV for increase (RCV+), and the log-normal RCV for decrease (RCV-). The CVi, CVg, RCV, RCV+, and RCV- were 28.2%, 35.6%, 78.6%, 116%, and -53.7%, respectively. The index of individuality was 0.79. CONCLUSIONS:The concentrations of galectin-3 in patients followed 12 months after HTx fluctuated around the homeostatic point, with CVi of approximately 28%. RCVs of +116% (log-normal increase) and -54% (log-normal decrease) mean that the concentration of galectin-3 would need to approximately double or decrease by half to indicate a new process.

journal_name

Clin Chem Lab Med

authors

Franeková J,Kubíček Z,Hošková L,Kotrbatá M,Sečník P,Kautzner J,Jabor A

doi

10.1515/cclm-2013-1088

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

119-23

issue

1

eissn

1434-6621

issn

1437-4331

pii

/j/cclm.ahead-of-print/cclm-2013-1088/cclm-2013-10

journal_volume

53

pub_type

临床试验,杂志文章
  • Customer satisfaction survey to improve the European cystic fibrosis external quality assessment scheme.

    abstract:BACKGROUND:The Cystic Fibrosis European Network, coordinated from within the Katholieke Universiteit Leuven, is the provider of the European cystic fibrosis external quality assessment (EQA) scheme. The network aimed to seek feedback from laboratories that participated in the cystic fibrosis scheme in order to improve ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2011.215

    authors: Berwouts S,Dequeker E

    更新日期:2011-08-01 00:00:00

  • Concentrations of plasma methylmalonic acid in 80-year-olds show only weak relation to psychological performance.

    abstract::Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.1999.142

    authors: Hultberg B,Jensen E,Dehlin O,Hagberg B,Samuelsson G,Svensson T

    更新日期:1999-10-01 00:00:00

  • Performance of strip-based glucose meters and cassette-based blood gas analyzer for monitoring glucose levels in a surgical intensive care setting.

    abstract:BACKGROUND:We verified the analytical performance of strip-based handheld glucose meters (GM) for prescription use, in a comparative split-sample protocol using blood gas samples from a surgical intensive care unit (ICU). METHODS:Freestyle Precision Pro (Abbott), StatStrip Connectivity Meter (Nova), ACCU-CHEK Inform I...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2014-1289

    authors: Claerhout H,De Prins M,Mesotten D,Van den Berghe G,Mathieu C,Van Eldere J,Vanstapel F

    更新日期:2016-01-01 00:00:00

  • Evaluation of commutability of control materials.

    abstract::The commutability of 13 control materials was evaluated by performing parallel measurements on two different analysers: a Synchron CX-5 Delta from Beckman-Coulter and a Vitros 950 from Ortho-Clinical Diagnostics. Twenty three clinical chemistry analytes (substrates, electrolytes and enzymatic activities) were determin...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2002.108

    authors: Brion E,Lessinger JM,Gould N,Leyendecker J,Férard G

    更新日期:2002-06-01 00:00:00

  • The high-sensitivity cardiac troponin T assay is superior to its previous assay generation for prediction of 90-day clinical outcome in ischemic stroke.

    abstract:BACKGROUND:Cardiac troponin T (cTnT) has been reported to be a predictor of stroke outcome. We hypothesized that the high-sensitivity cTnT (hs-cTnT) assay is superior to its previous assay generation for stroke outcome prediction. METHODS:cTnT was measured on emergency department admission in 60 consecutive patients (...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2012-0176

    authors: Furtner M,Ploner T,Hammerer-Lercher A,Pechlaner R,Mair J

    更新日期:2012-11-01 00:00:00

  • Searching for genes involved in hypertension development in special populations: children and pre-eclamptic women. Where are we standing now?

    abstract::Primary hypertension is a very common disorder particularly in the aging population but hypertensive disorders can appear earlier in life, especially when obesity and unhealthy lifestyle are present. Also pregnant women can be at risk of developing gestational hypertension and/or pre-eclampsia, which causes complicati...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1515/cclm-2013-0405

    authors: Danese E,Montagnana M,Fava C

    更新日期:2013-12-01 00:00:00

  • Fluorimetric quantitation of citalopram and escitalopram in plasma: developing an express method to monitor compliance in clinical trials.

    abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) in general, and citalopram/escitalopram in particular, are widely used to treat clinical depression. However, SSRI bioavailability and non-compliance represent major issues, especially in the clinical trials setting. In this context, frequent drug-level measure...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2007.108

    authors: Serebruany V,Malinin A,Dragan V,Atar D,van Zyl L,Dragan A,Lexapro Compliance Task Force.

    更新日期:2007-01-01 00:00:00

  • Biological variation and quantification of health: the emergence of the concept of normality.

    abstract::Historical research on the concept of normality, its roots and its development show that this concept has its sources in very different areas of scientific and medical thinking. Of great importance were: (i) a new theory of disease arising early in the 19th century supposing a continuous change from the healthy to the...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 历史文章,杂志文章

    doi:10.1515/CCLM.1998.013

    authors: Büttner J

    更新日期:1998-01-01 00:00:00

  • High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference.

    abstract:BACKGROUND:High-dose biotin therapy is beneficial in progressive multiple sclerosis (MS) and is expected to be adopted by a large number of patients. Biotin therapy leads to analytical interference in many immunoassays that utilize streptavidin-biotin capture techniques, yielding skewed results that can mimic various e...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2016-1183

    authors: Piketty ML,Prie D,Sedel F,Bernard D,Hercend C,Chanson P,Souberbielle JC

    更新日期:2017-05-01 00:00:00

  • Age-related changes in serum amino acids concentrations in healthy individuals.

    abstract:BACKGROUND:Serum amino acids, part of a pool of free amino acids, are influenced by metabolism and disease. Few reports exist describing their function and concentrations in serum. Our study aimed to determine age- and gender-related differences in serum amino acid concentrations in healthy Japanese patients, focusing ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2011-0846

    authors: Kouchiwa T,Wada K,Uchiyama M,Kasezawa N,Niisato M,Murakami H,Fukuyama K,Yokogoshi H

    更新日期:2012-01-04 00:00:00

  • Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy.

    abstract::Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% an...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1515/CCLM.2007.140

    authors: Bonnet E,Genoux A,Bernard J,Fauvel J,Massip P,Perret B

    更新日期:2007-01-01 00:00:00

  • Unexpected high plasma cobalamin : proposal for a diagnostic strategy.

    abstract::It is well-established that more than 8% of patients examined for vitamin B12 deficiency unexpectedly have increased plasma levels of the vitamin, but so far there are no guidelines for the clinical interpretation of such findings. In this review, we summarise known associations between high plasma cobalamin and disea...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1515/cclm-2012-0545

    authors: Arendt JF,Nexo E

    更新日期:2013-03-01 00:00:00

  • Maillard reaction products: some considerations on their health effects.

    abstract::For several decades, researchers have been investigating the relations between the consumption of Maillard reaction products (MRPs) and biological activities, whether harmful or beneficial. Interest in this area is growing because the intake of these compounds has increased in parallel with the consumption of thermall...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1515/cclm-2012-0823

    authors: Delgado-Andrade C

    更新日期:2014-01-01 00:00:00

  • Trace elements and bone health.

    abstract::The importance of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well known. Moreover, bone health is positively influenced by certain elements (e.g., zinc, copper, fluorine, manganese, magnesium, iron and boron). Deficiency of these elements slows down the increase of ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1515/cclm-2012-0868

    authors: Zofková I,Nemcikova P,Matucha P

    更新日期:2013-08-01 00:00:00

  • Alpha2-macroglobulin deletion polymorphism and plasma levels in late onset Alzheimer's disease.

    abstract::The acute-phase "panproteinase" inhibitor alpha2-macroglobulin (alpha2M), a protein involved in inflammatory reactions, has been identified in amyloid plaques in Alzheimer's disease (AD). In addition, alpha2M is involved in AD susceptibility at the genetic level, and a deletion polymorphism at the a2M gene has been fo...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2002.052

    authors: Scacchi R,Ruggeri M,Gambina G,Martini MC,Corbo RM

    更新日期:2002-04-01 00:00:00

  • The serum uromodulin level is associated with kidney function.

    abstract:BACKGROUND:In chronic kidney diseases of various etiologies, the urinary excretion of uromodulin is usually decreased in parallel with the glomerular filtration rate. This study aimed to investigate whether serum uromodulin is associated with kidney function. METHODS:Within the framework of the Seniorlabor study, a su...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2014-0505

    authors: Risch L,Lhotta K,Meier D,Medina-Escobar P,Nydegger UE,Risch M

    更新日期:2014-12-01 00:00:00

  • A knowledge-based system to aid with the clinical interpretation of complex serum protein data.

    abstract::In every area of science workers are finding increasing difficulty in managing the volume of available data. In medicine, the accelerating pace has the worrisome overtones of our failing to provide up-to-date care for our patients. In other information-intensive areas, we rely heavily on software that manages much of ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2001.170

    authors: Ritchie RF

    更新日期:2001-11-01 00:00:00

  • Elimination of serum complexed prostate-specific antigen after radical retropubic prostatectomy.

    abstract::Total prostate-specific antigen (PSA) and complexed PSA were determined in venous blood from 12 patients with prostate cancer before and after radical prostatectomy by using Immuno 1 PSA assays. The elimination kinetics of complexed PSA were compared with that of total PSA. Nearly constant concentrations of complexed ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2000.044

    authors: Stephan C,Jung K,Brux B,Lein M,Sinha P,Schnorr D,Loening SA

    更新日期:2000-04-01 00:00:00

  • Serum omentin-1 is a novel biomarker for predicting the functional outcome of acute ischemic stroke patients.

    abstract:BACKGROUND:Recent studies have suggested that omentin-1 plays a critical role in the development of cardiovascular disease. However, reported findings are inconsistent, and no study has evaluated the association between omentin-1 levels and a poor functional outcome after ischemic stroke onset. METHODS:A total of 266 ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2017-0282

    authors: Xu T,Zuo P,Wang Y,Gao Z,Ke K

    更新日期:2018-01-26 00:00:00

  • Multicenter evaluation of the analytical and clinical performance of the Elecsys S100 immunoassay in patients with malignant melanoma.

    abstract::The aim of this multicenter study was to evaluate the technical and clinical performance of the Elecsys S100 electrochemiluminescence immunoassay and to assess its utility as a tumor marker in patients with malignant melanoma. Imprecision studies yielded within-run coefficients of variation (CVs) of 0.7-2.0% and betwe...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1515/CCLM.2005.097

    authors: Alber B,Hein R,Garbe C,Caroli U,Luppa PB

    更新日期:2005-01-01 00:00:00

  • Free light chains and heavy/light chains in monitoring POEMS patients.

    abstract:BACKGROUND:POEMS syndrome is defined by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes. The vascular endothelial growth factor (VEGF) appears to play a key role in the pathogenesis of the syndrome, and its concentrations are deemed to correlate to disease activity. The aim of the p...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2015-0910

    authors: Altinier S,Proko K,Zaninotto M,Ciubotaru D,Seguso M,Varagnolo M,Lessi F,Briani C,Adami F,Plebani M

    更新日期:2016-06-01 00:00:00

  • Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation.

    abstract:BACKGROUND:Gastrointestinal toxicity is the principal toxicity of chemoradiation in the treatment of rectal carcinoma. The assessment of this toxicity still relies mostly on the symptoms reported by the patient. METHODS:Plasma citrulline, serum neopterin and urinary neopterin were followed weekly in 49 patients with r...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2015-0326

    authors: Zezulová M,Bartoušková M,Hlídková E,Adam T,Kujovská Krčmová L,Červinková B,Solichová D,Zlevorová M,Cwiertka K,Friedecký D,Vrána D,Melichar B

    更新日期:2016-02-01 00:00:00

  • Sensitive detection of EML4-ALK fusion oncoprotein of lung cancer by in situ proximity ligation assay.

    abstract:BACKGROUND:EML4-ALK fusion oncogene has emerged as a novel molecular target in non-small cell lung cancer (NSCLC). Although break-apart fluorescent in situ hybridization (FISH) is the standard method for diagnosis, it is expensive, not readily available and sometimes difficult to interpret. In addition, ALK immunohisto...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2013-0044

    authors: Rho JK,Lee H,Park CS,Choi CM,Lee JC

    更新日期:2013-09-01 00:00:00

  • The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis.

    abstract:BACKGROUND:Angiotensin II is produced primarily by angiotensin I-converting enzyme (ACE) within atherosclerotic lesions and ACE level in plaques correlates with the severity of vessel wall damage. Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of a...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2008.101

    authors: Niemiec P,Zak I,Wita K

    更新日期:2008-01-01 00:00:00

  • Sensitive immunoassays for the autoantibodies reacting against citrullinated carboxy-terminal telopeptides of type I and type II collagens in patients with rheumatoid arthritis.

    abstract::We developed sensitive assay methods for autoantibodies recognizing the citrullinated synthetic peptides derived from type I and type II collagens in patients with rheumatoid arthritis (RA). These peptides were tested with the chemiluminescence method (Nichols Advantage System). In 44 RA patients out of 120, the sera ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2005.239

    authors: Koivula MK,Ramberg J,Aman S,Karjalainen A,Hakala M,Risteli J

    更新日期:2005-01-01 00:00:00

  • Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: II. Performance of a laboratory network running the HPLC candidate reference measurement procedure and evaluation of a candidate reference material.

    abstract::Carbohydrate-deficient transferrin (CDT) is a descriptive term used for a temporary change in the transferrin glycosylation profile caused by alcohol, and used as a biomarker of chronic high alcohol consumption. The use of an array of methods for measurement of CDT in various absolute or relative amounts, and sometime...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2010.322

    authors: Helander A,Wielders JP,Jeppsson JO,Weykamp C,Siebelder C,Anton RF,Schellenberg F,Whitfield JB,IFCC Working Group on Standardization of Carbohydrate-Deficient Transferrin (WG-CDT).

    更新日期:2010-11-01 00:00:00

  • Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease.

    abstract::Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is unclear. We and others have reported that homocysteine (Hcy) is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apoA-I) in patie...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1515/CCLM.2007.358

    authors: Liao D,Yang X,Wang H

    更新日期:2007-01-01 00:00:00

  • Evaluation of clinical cases in External Quality Assessment Scheme (EQAS) for the urinary sediment.

    abstract:BACKGROUND:The few available External Quality Assessment (EQA) programs on urinary sediment rarely include an evaluation of clinical cases. The present paper provides a descriptive analysis of clinical cases included in the Italian EQA program on urinary sediment. METHODS:Ten cases were presented over a 5-year period ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2013-0785

    authors: Fogazzi GB,Secchiero S,Garigali G,Plebani M

    更新日期:2014-06-01 00:00:00

  • Bovine spongiform encephalopathy: are the cows mad or full of carbohydrates?

    abstract::The non-forage feeding of dairy cows rich in fast absorption carbohydrates, the low value of their euglycemic-hyperinsulinemic clamp suggest a dysregulation of carbohydrate metabolism able to produce neurodegenerative disorders. Comparisons between Alzheimer's disease developed in diabetes mellitus and bovine spongifo...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/CCLM.2002.018

    authors: Frey J

    更新日期:2002-02-01 00:00:00

  • Elecsys® and Kryptor immunoassays for the measurement of sFlt-1 and PlGF to aid preeclampsia diagnosis: are they comparable?

    abstract::Background For pregnant women with suspected preeclampsia, the soluble fms-like tyrosine-kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio is a biomarker to aid diagnosis. We performed method comparisons between Elecsys® and Kryptor sFlt-1 and PlGF immunoassays and assessed the diagnostic performance for preeclam...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章

    doi:10.1515/cclm-2018-1228

    authors: Stepan H,Hund M,Dilba P,Sillman J,Schlembach D

    更新日期:2019-08-27 00:00:00