Searching for genes involved in hypertension development in special populations: children and pre-eclamptic women. Where are we standing now?

abstract：:There are large differences in the use of laboratory tests between hospitals in Sweden. These differences are not only due to differences between the patients treated but also to differences in practice. Use of laboratory test seems to reflect local traditions to a large extent. These large variations in practice are ...

journal_title：Clinical chemistry and laboratory medicine

authors： Larsson A,Palmer M,Hultén G,Tryding N

更新日期：2000-05-01 00:00:00

abstract：:Protein-coding genes comprise only 3% of the human genome, while the genes that are transcribed into RNAs but do not code for proteins occupy majority of the genome. Once considered as biological darker matter, non-coding RNAs are now being recognized as critical regulators in cancer genome. Among the many types of no...

journal_title：Clinical chemistry and laboratory medicine

authors： Ling H,Girnita L,Buda O,Calin GA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The purpose of an external quality assessment (EQA) is to evaluate the analytical capability of clinical laboratories, identify differences among the laboratories and improve analytical quality. Our EQA results show that the rates of unsatisfactory performance for thyroid hormone tests were the highest in al...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhou Q,Li S,Li X,Wang W,Wang Z

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:High-dose biotin therapy is beneficial in progressive multiple sclerosis (MS) and is expected to be adopted by a large number of patients. Biotin therapy leads to analytical interference in many immunoassays that utilize streptavidin-biotin capture techniques, yielding skewed results that can mimic various e...

journal_title：Clinical chemistry and laboratory medicine

authors： Piketty ML,Prie D,Sedel F,Bernard D,Hercend C,Chanson P,Souberbielle JC

更新日期：2017-05-01 00:00:00

abstract：:Evidence of the acute lack of interchangeable laboratory results and consensus in current practice among clinical laboratories has underpinned greater attention to standardization and harmonization projects. Although the focus is mainly on the standardization of measurement procedures, the scope of harmonization goes ...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M

更新日期：2013-04-01 00:00:00

abstract：:Phenylketonuria is an inherited metabolic disease, which is characterized by an increased level of serum phenylalanine. Quantitative measurement of phenylalanine in the serum of phenylketonuria patients is necessary to confirm the disease, and to distinguish phenylketonuria from other forms of hyperphenylalaninemia. I...

journal_title：Clinical chemistry and laboratory medicine

authors： Vallian S,Moeini H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In analogy with other areas of laboratory diagnostics, the pre-analytical phase is the leading source of variability also in urinalysis. We carried out a multicentric study for comparing results obtained from first-voided and mid-stream urine samples. METHODS:Each of the six hospital-based clinical laborato...

journal_title：Clinical chemistry and laboratory medicine

authors： Manoni F,Gessoni G,Alessio MG,Caleffi A,Saccani G,Silvestri MG,Poz D,Ercolin M,Tinello A,Valverde S,Ottomano C,Lippi G

更新日期：2011-12-20 00:00:00

abstract：:The aim of this work was to assess the diagnostic value of anti-CCP-3 and anti-CCP-2 for the diagnosis of rheumatoid arthritis (RA) and determine whether anti-CCP-3 more accurately identifies patients with rheumatoid arthritis than anti-CCP-2. PubMed and CNKI databases were searched for studies published in English an...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhang WC,Wu H,Chen WX

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Non-invasive biochemical markers are needed to support the diagnosis of ulcerative colitis (UC), an incurable disease of unknown pathology. Midkine is an angiogenic cytokine, chemotactic towards neutrophils and macrophages, and a T-regulatory cell suppressor. METHODS:Serum midkine was measured immunoenzymat...

journal_title：Clinical chemistry and laboratory medicine

authors： Krzystek-Korpacka M,Neubauer K,Matusiewicz M

更新日期：2009-01-01 00:00:00

abstract：:The aim of the study was to evaluate the clinical efficiency of soluble transferrin receptor and transferrin receptor-ferritin index (sTfR/logF) in the diagnosis of iron deficiency anemia, as well as the differential diagnosis of iron deficiency anemia and anemia in rheumatoid arthritis. The study included 96 patients...

journal_title：Clinical chemistry and laboratory medicine

authors： Margetic S,Topic E,Ruzic DF,Kvaternik M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Linezolid is the first synthetic compound of a new group of antimicrobials, the oxazolidinones, which inhibit protein synthesis. It shows a broad spectrum of activity against Gram positive organisms. With respect to its pharmacokinetics, linezolid shows a relatively high volume of distribution and good penet...

journal_title：Clinical chemistry and laboratory medicine

authors： Guerrero L,Martínez-Olondris P,Rigol M,Esperatti M,Esquinas C,Luque N,Piñer R,Torres A,Soy D

更新日期：2010-03-01 00:00:00

abstract：Objectives:Colorectal cancer (CRC) screening using stool samples is now in routine use where tumor DNA methylation analysis for leading markers such as NDRG4 and SDC2 is an integral part of the test. However, processing stool samples for reproducible and efficient extraction of human genomic DNA remains a bottleneck fo...

journal_title：Clinical chemistry and laboratory medicine

authors： Jin S,Ye Q,Hong Y,Dai W,Zhang C,Liu W,Guo Y,Zhu D,Zhang Z,Chen S,Wang Y,Li D,Ma W,Yang Z,Li J,Zheng Z,Luan J,Wu X,Jiang F,Xu C,Ding C

更新日期：2020-07-16 00:00:00

abstract：:Nitric oxide (NO) activates soluble guanylyl cyclase, which results in an increased synthesis of cyclic guanosine 3',5'-cyclic monophosphate (cGMP), smooth muscle relaxation and vasodilation. The heme group in soluble guanylyl cyclase binds NO and allosterically activates the catalytic site. In addition, a second allo...

journal_title：Clinical chemistry and laboratory medicine

authors： Nakane M

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Fatty acid metabolites play a key role in numerous physiological and pathological processes. A rapid liquid chromatography-mass spectrometry assay for the simultaneous determination of prostanoids, isoprostane and lipoxygenase (LOX) derived fatty acid metabolites in a small biological sample of only 20 micro...

journal_title：Clinical chemistry and laboratory medicine

authors： Unterwurzacher I,Koal T,Bonn GK,Weinberger KM,Ramsay SL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Automated systems have been broadly used in the counting of particles in urine, while manual microscopic analyses are still required for confirming components of urine sediments, especially pathologic casts and other unknown particles. Good review rules can reduce the number of manual urine microscopy examin...

journal_title：Clinical chemistry and laboratory medicine

authors： Cao Y,Cheng M,Hu C

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Whereas N-terminal pro-brain natriuretic peptide (NT-proBNP) is approved for risk stratification of patients with acute coronary syndromes (ACS), short-term temporal changes in NT-proBNP concentrations and the optimal time points for sampling are not clear. The purpose of this study was to better define the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Buchner S,Debl K,Barlage S,Griese D,Fredersdorf S,Jeron A,Lubnow M,Müller T,Muders F,Holmer S,Riegger GA,Luchner A

更新日期：2010-06-01 00:00:00

abstract：:For several decades, researchers have been investigating the relations between the consumption of Maillard reaction products (MRPs) and biological activities, whether harmful or beneficial. Interest in this area is growing because the intake of these compounds has increased in parallel with the consumption of thermall...

journal_title：Clinical chemistry and laboratory medicine

authors： Delgado-Andrade C

更新日期：2014-01-01 00:00:00

abstract：:Volatile biomarker analysis in exhaled breath is becoming one of the desirable strategies for cancer detection because it may offer a relatively inexpensive, rapid, and non-invasive screening method for early diagnosis. Breath analysis has attracted a considerable amount of scientific and clinical interest over the pa...

journal_title：Clinical chemistry and laboratory medicine

authors： Badjagbo K

更新日期：2012-11-01 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：:In the relatively short time frame since the introduction of next generation sequencing, it has become a method of choice for complex genomic research studies. As a paradigm shifting technology, we are now witnessing its translation into clinical diagnostic laboratories for patient care. Multi-gene panels for a variet...

journal_title：Clinical chemistry and laboratory medicine

authors： Coonrod EM,Margraf RL,Voelkerding KV

更新日期：2011-12-23 00:00:00

abstract：:Collagenous proteins are especially prone to nonenzymatic glycation, because they contain several dibasic amino acid residues with free amino groups, have a very slow turnover rate, and are exposed to ambient levels of glucose. The aim of this study was to determine the time-dependent course of advanced glycation proc...

journal_title：Clinical chemistry and laboratory medicine

authors： Turk Z,Misur I,Turk N,Benko B

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Haemoglobin (Hb) variants are well-known factors interfering with accurate HbA1c testing. This report describes two novel Hb variants leading to inappropriate quantification of HbA1c by ion-exchange chromatography. METHODS:Glycated forms of novel Hb variants were recognised in the blood of two patients with...

journal_title：Clinical chemistry and laboratory medicine

authors： Bots M,Stroobants AK,Delzenne B,Soeters MR,de Vries JE,Weykamp CW,Norg RJ,Veldthuis M,Zwieten Rv

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:A crucial question when developing reference intervals is whether different subpopulations need their own reference interval or if a single joint reference interval can be used. It is reasonable to use partitioned reference intervals in situations where a single interval results in considerable variation in ...

journal_title：Clinical chemistry and laboratory medicine

authors： Gellerstedt M,Petersen PH

更新日期：2007-01-01 00:00:00

abstract：:Cryoglobulins are proteins that precipitate at temperatures below 37 degrees C. Cold-induced precipitation of proteins may occur in vivo secondary to several important diseases, and lead to pathological manifestations involving different organs. Cryoprecipitation may be observed in vitro by exposing serum samples, sup...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Stasio E,Bizzarri P,Bove M,Casato M,Giardina B,Fiorilli M,Galtieri A,Pucillo LP

更新日期：2003-02-01 00:00:00

abstract：:Point-of-care testing (POCT) is the fastest growing segment of a US$30 billion worldwide market. "Errors" in the testing process, as well as medical data interpretation and treatment associated with POCT, are recognized as leading to major compromises of patient safety. In today's environment, most testing errors (pre...

journal_title：Clinical chemistry and laboratory medicine

authors： Ehrmeyer SS,Laessig RH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The immunoglobulin superfamily receptor translocation-associated 2 (IRTA2) gene encodes both membrane and secreted forms of the B-cell differentiation antigen (also identified as FcRH5). The membrane form is highly expressed on the surface of hairy cell leukemia (HCL) cells from patients. This study aimed to...

journal_title：Clinical chemistry and laboratory medicine

authors： Ise T,Kreitman RJ,Pastan I,Nagata S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:When certain inflammatory processes occur, toxic granulation neutrophils (TGNs) appear in the blood showing prominent cytoplasmic granules. Currently, the granularity of TGNs is analyzed by manual microscopy of blood smears. The SYSMEX XE-5000 is an automated hematology analyzer, which can measure toxic gran...

journal_title：Clinical chemistry and laboratory medicine

authors： Zimmermann M,Cremer M,Hoffmann C,Weimann K,Weimann A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Urinary enzymes, including the brush border enzyme alanine aminopeptidase (AAP), are reliable biomarkers of nephrotoxicity and represent early indicators of tubular damage. The aim of the present study was to develop and validate an automated urinary AAP activity assay. METHODS AND RESULTS:For this purpose,...

journal_title：Clinical chemistry and laboratory medicine

authors： Holdt B,Peters E,Nagel HR,Steiner M

更新日期：2008-01-01 00:00:00

abstract：:Background Intravascular hemolysis and in vitro hemolysis are prevalent contributors to failed blood sample analysis in the routine hospital laboratory. Interferences by hemoglobin in spectrophotometric and certain enzyme activity assays is the major causative factor. Methods By exploiting the hemoglobin-binding prope...

journal_title：Clinical chemistry and laboratory medicine

authors： Sæderup KL,Revsholm J,Richardt PB,Christiansen SH,Hennig D,Moestrup SK,Graversen JH

更新日期：2019-10-25 00:00:00