Harmonization in laboratory medicine: the complete picture.

abstract：BACKGROUND:To date, no practical tools are available to obtain optimal settings for moving average (MA) as a continuous analytical quality control instrument. Also, there is no knowledge of the true bias detection properties of applied MA. We describe the use of bias detection curves for MA optimization and MA validati...

journal_title：Clinical chemistry and laboratory medicine

authors： van Rossum HH,Kemperman H

更新日期：2017-02-01 00:00:00

abstract：:Microsatellite typing is frequently used in disease diagnosis and in genetic association studies. Inter-study consistency and comparability is essential in both applications. In this study, we show that the interlaboratory comparison of microsatellite sizes is often discrepant and misleading. This is a matter of great...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossouw M,Warren R,Hoal EG

更新日期：2002-09-01 00:00:00

abstract：:A software has been developed on quality control, department economics, information supervise and personal administration. In this article, we discuss the part of quality control, from which we benefit most, on developing ideas, running principle, and application. This network will enable the implementation of total q...

journal_title：Clinical chemistry and laboratory medicine

authors： Yulong C

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Proteogenomics is an emerging field at the intersection of genomics and proteomics. Many variant peptides corresponding to single nucleotide variations (SNVs) are associated with specific diseases. The aim of this study was to demonstrate the feasibility of proteogenomic-based variant peptide detection in di...

journal_title：Clinical chemistry and laboratory medicine

authors： Dimitrakopoulos L,Prassas I,Berns EMJJ,Foekens JA,Diamandis EP,Charames GS

更新日期：2017-08-28 00:00:00

abstract：:The availability of so-called high-sensitivity troponin assays (hsTn) has scored a compelling goal for laboratory medicine, allowing the safe clinical application of international recommendations for the definition of acute myocardial infarction (AMI). However, the introduction of hsTn has not been welcomed by clinici...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Panteghini M

更新日期：2015-04-01 00:00:00

abstract：:There is some evidence from recent observational studies that hyperhomocysteinemia is a risk factor for cognitive dysfunction, including Alzheimer's disease and vascular dementia. There are only a few intervention studies, and the results are disappointing for such a frequent disease. Prospective double-blind and plac...

journal_title：Clinical chemistry and laboratory medicine

authors： Joosten E

更新日期：2001-08-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is present in more than 90% of patients with congenital adrenal hyperplasia, an inherited metabolic disorder of adrenal steroidogenesis. Impaired enzymatic activity leads to the accumulation of metabolic intermediates (progesterone and 17-hydroxyprogesterone), which results in excessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Concolino P,Mello E,Zuppi C,Capoluongo E

更新日期：2010-08-01 00:00:00

abstract：:In the relatively short time frame since the introduction of next generation sequencing, it has become a method of choice for complex genomic research studies. As a paradigm shifting technology, we are now witnessing its translation into clinical diagnostic laboratories for patient care. Multi-gene panels for a variet...

journal_title：Clinical chemistry and laboratory medicine

authors： Coonrod EM,Margraf RL,Voelkerding KV

更新日期：2011-12-23 00:00:00

abstract：BACKGROUND:Autoantibodies against β1-adrenergic receptors (β1AR) that stimulate cardiac cAMP-production play a causal role in the pathogenesis of human heart failure. Patients can be subjected to specific therapies, if the presence of potentially cardio-noxious β1AR-autoantibodies is reliably diagnosed. This requires a...

journal_title：Clinical chemistry and laboratory medicine

authors： Bornholz B,Benninghaus T,Reinke Y,Felix SB,Roggenbuck D,Jahns-Boivin V,Jahns R,Boege F

更新日期：2016-04-01 00:00:00

abstract：:We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique. Insulin action, as evaluated by glu...

journal_title：Clinical chemistry and laboratory medicine

authors： Stanická S,Vondra K,Pelikánová T,Vlcek P,Hill M,Zamrazil V

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS:In a prospective...

journal_title：Clinical chemistry and laboratory medicine

authors： Behnes M,Papassotiriou J,Walter T,Fiedler E,Sauer T,Lang S,Elmas E,Hoffmann U,Borggrefe M,Brueckmann M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The plasma total and low-density lipoprotein-cholesterol (LDL-C) levels that are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the general population are too stringent for use in relatives, given the higher prior probability of a first-degree relative being FH (50% vs. 1/500...

journal_title：Clinical chemistry and laboratory medicine

authors： Starr B,Hadfield SG,Hutten BA,Lansberg PJ,Leren TP,Damgaard D,Neil HA,Humphries SE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Measurement of late-night salivary cortisol concentrations is increasingly used as a screening test in suspected Cushing's syndrome. Cortisol concentrations are typically extremely low in late-night samples and discordant assay-specific reference ranges have been reported. Therefore, the aim of our study was...

journal_title：Clinical chemistry and laboratory medicine

authors： Vogeser M,Durner J,Seliger E,Auernhammer C

更新日期：2006-01-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a potent inhibitor of nitric oxide synthase and is regarded as a novel risk factor for cardiovascular disease. The metabolic pathways of ADMA and homocysteine are strongly intertwined. First, during synthesis of ADMA, two equivalents of homocysteine are formed. Second, homocystein...

journal_title：Clinical chemistry and laboratory medicine

authors： Teerlink T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively contain RNA (small RNAs and mRNAs) and harbor unique subset of proteins, r...

journal_title：Clinical chemistry and laboratory medicine

authors： Channavajjhala SK,Rossato M,Morandini F,Castagna A,Pizzolo F,Bazzoni F,Olivieri O

更新日期：2014-03-01 00:00:00

abstract：:Human protein 1/Clara cell Mr 10,000 protein consists of two identical subunits of seventy amino acid residues each. In the present study, eight clones of monoclonal antibodies against native protein 1 were prepared and their respective epitopes were immunochemically and immunohistochemically characterized using nativ...

journal_title：Clinical chemistry and laboratory medicine

authors： Yamaguchi T,Yamada T,Okutani R,Shijubo N,Singh G,Itoh Y

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analy...

journal_title：Clinical chemistry and laboratory medicine

authors： Cangemi G,Storti S,Cantinotti M,Fortunato A,Emdin M,Bruschettini M,Bugnone D,Melioli G,Clerico A

更新日期：2013-05-01 00:00:00

abstract：:Quality in diagnostic testing represents a key target of laboratory medicine, for which an assurance around the quality of testing is expected from all involved in the process. Laboratories attempt to assure the quality of their testing by various processes, but especially by performance of internal quality control an...

journal_title：Clinical chemistry and laboratory medicine

authors： Favaloro EJ,Jennings I,Olson J,Van Cott EM,Bonar R,Gosselin R,Meijer P

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Accurate outcome prediction in gastroesophageal malignancies is challenging. Acute-phase response proteins (APRPs) have been claimed to be independent prognosticators, although the basis for their association with prognosis remains unexplained. We hypothesized that, similarly to pancreatic and lung cancers, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Krzystek-Korpacka M,Matusiewicz M,Diakowska D,Grabowski K,Blachut K,Kustrzeba-Wojcicka I,Terlecki G,Gamian A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS:In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) dif...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim HN,Hur M,Kim H,Kim SW,Moon HW,Yun YM

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:The objective of the study was to find the incidence of hemolysis in samples transported through a pneumatic tube system (PTS) at different speeds. METHODS:This prospective observational study was done in three phases: "short distance and high speed (115 m at 3 m/s)", "long distance and high speed (225 m at...

journal_title：Clinical chemistry and laboratory medicine

authors： Tiwari AK,Pandey P,Dixit S,Raina V

更新日期：2011-11-10 00:00:00

abstract：:Chronic rejection accounts for the greatest loss of renal allografts. HLA mismatching has been minimised by organ allocation and new immunosuppressive drugs have been employed, but the average cadaveric graft survival still does not exceed 12 years. Though the aetiology is multifactorial, one contributory factor for t...

journal_title：Clinical chemistry and laboratory medicine

authors： Gerstenkorn C,Robertson H,Mohamed MA,O'Donnell M,Ali S,Talbot D

更新日期：2000-11-01 00:00:00

abstract：:Objectives Cerebrospinal fluid (CSF) is a clear, colorless body fluid filling the central nervous system. The determination of the CSF total protein (TP) content represents an important screening test of various pathologies. We aimed to address the effect of sex and age on CSF-TP content and the use of the current upp...

journal_title：Clinical chemistry and laboratory medicine

authors： Castellazzi M,Pizzicotti S,Lombardo I,Alfiero S,Morotti A,Pellegatti P,Negri G,Natali L,Ferri C,Fainardi E,Bellini T,Pugliatti M

更新日期：2020-10-25 00:00:00

abstract：BACKGROUND:The VU University Medical Center (VUmc) was the first hospital in the Netherlands to introduce the Delfia Xpress for the analysis of free beta-human chorionic gonadotrophin (beta-hCG) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester screening program for Down syndrome. Since then, ot...

journal_title：Clinical chemistry and laboratory medicine

authors： Linskens IH,Levitus M,Frans A,Schielen PC,van Vugt JM,Blankenstein MA,Dijstelbloem HM

更新日期：2009-01-01 00:00:00

abstract：:Background The present study was undertaken to evaluate the clinical impact of a thyroglobulin (Tg) minirecovery test (Tg-mRec) in a large series of differentiated thyroid carcinoma (DTC) patients treated and monitored homogeneously in a tertiary referral center. Methods Included were 1120 serum samples from 798 DTC p...

journal_title：Clinical chemistry and laboratory medicine

authors： Giovanella L,Verburg FA,Trimboli P,Imperiali M,Keller F,Ceriani L

更新日期：2019-07-26 00:00:00

abstract：:Measurement of S-100B protein in serum or cerebrospinal fluid is increasingly used as a molecular marker of brain damage. However, there is no information about the pre-analytical in vitro stability of S-100B. We have investigated whether storing blood samples at different time periods and conditions affected the meas...

journal_title：Clinical chemistry and laboratory medicine

authors： Raabe A,Kopetsch O,Gross U,Zimmermann M,Gebhart P

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:It has been proposed that only anti-thyroid-peroxidase (TPOAb) and not anti-thyroglobulin (TgAb) antibodies should be assayed in the diagnosis of autoimmune thyroid disease (AITD). METHODS:We analyzed the thyroid autoantibody profile with a multiplex bead array system, which allows simultaneous measurement ...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,Villalta D,Kodermaz G,Bagnasco M,Tonutti E,Bizzaro N

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to provide inter-laboratory imprecision comparisons of different groups of diagnostic systems as well as a comparison of professional laboratories with medical offices performance on the basis of 88,429 glucose results obtained in external quality assessment (EQA) schemes organized ...

journal_title：Clinical chemistry and laboratory medicine

authors： Morandi PA,Deom A,Kesseler D,Cohen R

更新日期：2010-09-01 00:00:00

abstract：:The concentration of leukocyte elastase/alpha1-proteinase inhibitor complexes in plasma and polymorphonuclear neutrophil extracts, and plasma trypsin inhibitory capacity were determined in 88 patients with type 2 diabetes and 47 control subjects. Higher values of these variables were found in patients as compared to c...

journal_title：Clinical chemistry and laboratory medicine

authors： Piwowar A,Knapik-Kordecka M,Warwas M

更新日期：2000-12-01 00:00:00

abstract：:Early diagnosis of cobalamin deficiency is crucial, owing to the latent nature of this disorder and the resulting possible irreversible neurological damage. A normal serum cobalamin concentration does not reliably rule out a functional cobalamin deficiency and there does not at present seem to be any single diagnostic...

journal_title：Clinical chemistry and laboratory medicine

authors： Nilsson K,Isaksson A,Gustafson L,Hultberg B

更新日期：2004-01-01 00:00:00