Sexual dimorphism in the cerebrospinal fluid total protein content.

abstract：BACKGROUND:Rivaroxaban, a direct Xa inhibitor, is one of the new oral antithrombotic agents for which laboratory monitoring is thought to be unnecessary in most cases due to predictable pharmacokinetics. Circumstances are conceivable, however, in which reliable laboratory testing of Rivaroxaban is desirable. The aim of...

journal_title：Clinical chemistry and laboratory medicine

authors： Molenaar PJ,Dinkelaar J,Leyte A

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:After the re-introduction of ImmunoCAP® ISAC sIgE 112 on the market, we undertook a study to evaluate the performance of this multiplex-based immunoassay for IgE measurements to allergen components. METHODS:The study was carried out at 22 European and one South African site. Microarrays from different batch...

journal_title：Clinical chemistry and laboratory medicine

authors： van Hage M,Schmid-Grendelmeier P,Skevaki C,Plebani M,Canonica W,Kleine-Tebbe J,Nystrand M,Jafari-Mamaghani M,Jakob T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Polymorphisms of the gene for C-reactive protein (CRP) alter baseline serum CRP concentrations. The impact of polymorphisms of the CRP gene (genotype) on the normal range for CRP concentrations (phenotype) has not been determined. This study evaluated the median serum CRP concentrations in normal subjects st...

journal_title：Clinical chemistry and laboratory medicine

authors： Jones J,Chen LS,Baudhuin L,Peterson S,Harmsen WS,Zinsmeister AR,McConnell J,Sandborn WJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Pertussis has been increasing in frequency and can cause protean manifestation in infants, often resulting in extensive laboratory evaluation. METHODS:We examined the prevalence of cerebrospinal fluid (CSF) anomalies in infants with pertussis and parapertussis over a 5-year period. RESULTS:In total, 239 of...

journal_title：Clinical chemistry and laboratory medicine

authors： Chu TT,Groh J,Cruz AT

更新日期：2011-08-01 00:00:00

abstract：:The formation of superoxide partially accounts for the well-known oxygen enhancement of radiation-induced biochemical changes and cell damage. Radioprotective effects of copper (II), manganese (IV) or vanadium (IV) complexes, of superoxide dismutase-mimetic activity, on body weight, survival rate and some biochemical ...

journal_title：Clinical chemistry and laboratory medicine

authors： Abou-Seif MA,El-Naggar MM,El-Far M,Ramadan M,Salah N

更新日期：2003-07-01 00:00:00

abstract：:The preterm premature rupture of membranes (PPROM) is a common condition in pregnant women and is associated with significant maternal and perinatal morbidity. Most of the time, the diagnosis is done during physical examination. However, in 10%-20% of equivocal cases, biological markers are needed to confirm the diagn...

journal_title：Clinical chemistry and laboratory medicine

authors： Marcellin L,Goffinet F

更新日期：2012-04-14 00:00:00

abstract：BACKGROUND:Non-invasive biochemical markers are needed to support the diagnosis of ulcerative colitis (UC), an incurable disease of unknown pathology. Midkine is an angiogenic cytokine, chemotactic towards neutrophils and macrophages, and a T-regulatory cell suppressor. METHODS:Serum midkine was measured immunoenzymat...

journal_title：Clinical chemistry and laboratory medicine

authors： Krzystek-Korpacka M,Neubauer K,Matusiewicz M

更新日期：2009-01-01 00:00:00

abstract：:Cancers of the respiratory tract (lung and head and neck) share common aetiologies, risk factors and molecular characteristics. Epigenetic reprogramming is one of the hallmarks of cancer and DNA methylation is currently the best-studied form. There are a number of characteristics of DNA methylation, which seem advanta...

journal_title：Clinical chemistry and laboratory medicine

authors： Markopoulou S,Nikolaidis G,Liloglou T

更新日期：2012-10-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：:A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal bl...

journal_title：Clinical chemistry and laboratory medicine

authors： Heidrich JP,Niemeier A,Seyfarth M

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Post-menopausal osteoporosis (PO) affecting a large fraction of elderly women, is triggered by the decline in 17β-estradiol (E2) level. Experimental studies in animal models and cell cultures have suggested that the fall in E2 might contribute to developing oxidative stress (OS) which in turn is believed to ...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Bonaccorsi G,Cremonini E,Bergamini CM,Patella A,Castaldini C,Ferrazzini S,Capatti A,Picarelli V,Pansini FS,Massari L

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validat...

journal_title：Clinical chemistry and laboratory medicine

authors： Badrnya S,Doherty T,Richardson C,McConnell RI,Lamont JV,Veitinger M,FitzGerald SP,Zellner M,Umlauf E

更新日期：2018-04-25 00:00:00

abstract：:Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% an...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonnet E,Genoux A,Bernard J,Fauvel J,Massip P,Perret B

更新日期：2007-01-01 00:00:00

abstract：:The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chemotherapy for metastati...

journal_title：Clinical chemistry and laboratory medicine

authors： Sölétormos G,Petersen PH,Dombernowsky P

更新日期：2000-05-01 00:00:00

abstract：:We evaluated the analytical performance of the Immulite 2000 immunoassay analyzer (Diagnostic Products Corporation, Los Angeles, USA) based on a new detection technology, electrochemical luminescence. The evaluated analytes were thyrotropin, triiodothyronine, free thyroxine, follitropin, lutropin, prolactin, cortisol,...

journal_title：Clinical chemistry and laboratory medicine

authors： Tello FL,Hernández DM

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analy...

journal_title：Clinical chemistry and laboratory medicine

authors： Cangemi G,Storti S,Cantinotti M,Fortunato A,Emdin M,Bruschettini M,Bugnone D,Melioli G,Clerico A

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Plasma non-esterified (free) fatty acid concentrations rise as a consequence of stimulated endogenous lipolysis and are inversely related to the plasma magnesium concentration when plasma adrenaline concentration is increased. The aim of the study was to test whether high plasma non-esterified fatty acid conc...

journal_title：Clinical chemistry and laboratory medicine

authors： de Valk HW,Bianchi R,van Rijn HJ,Erkelens DW

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The compatibility of immunoassay tests in different sample matrices is extremely important during the assay validation process. In this study, we investigated the interchangeability of some Access (and therefore all the UniCel Family platforms) assays between serum and plasma. METHODS:We tested approximatel...

journal_title：Clinical chemistry and laboratory medicine

authors： Vignati G,Chiecchio A,Osnaghi B,Giovanelli L,Meloncelli C

更新日期：2008-01-01 00:00:00

abstract：:Carbohydrate-deficient transferrin (CDT) is a descriptive term used for a temporary change in the transferrin glycosylation profile caused by alcohol, and used as a biomarker of chronic high alcohol consumption. The use of an array of methods for measurement of CDT in various absolute or relative amounts, and sometime...

journal_title：Clinical chemistry and laboratory medicine

authors： Helander A,Wielders JP,Jeppsson JO,Weykamp C,Siebelder C,Anton RF,Schellenberg F,Whitfield JB,IFCC Working Group on Standardization of Carbohydrate-Deficient Transferrin (WG-CDT).

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Detection of systemic sclerosis-associated autoantibodies (SSc-Ab) is mostly restricted to anti-centromere and anti-topoisomerase-I. However, anti-RNA-polymerase-III and anti-PM/Scl are also important diagnostic markers for the disease supporting their incorporation in the laboratory repertoire. The aim of t...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonroy C,Smith V,Van Steendam K,Van Praet J,Deforce D,Devreese K,De Keyser F

更新日期：2013-11-01 00:00:00

abstract：:Authors are usually invited to follow the instructions to authors in scientific journals, because this section is likely to contain unique requirements, such as the references style requested. Authors not only must accurately check the instructions, but are also expected to verify references against the original docum...

journal_title：Clinical chemistry and laboratory medicine

authors： Salvagno GL,Lippi G,Montagnana M,Guidi GC

更新日期：2008-01-01 00:00:00

abstract：:Many limitations and conflicting results have cast serious doubts on the validity of cerebrospinal fluid tau and Abeta42 levels for the biological diagnosis of Alzheimer's disease, particularly extreme variations of the reference limits found by unrelated groups as a consequence of different reference populations used...

journal_title：Clinical chemistry and laboratory medicine

authors： Burkhard PR,Fournier R,Mermillod B,Krause KH,Bouras C,Irminger I

更新日期：2004-04-01 00:00:00

abstract：:The present paper describes an evaluation of the interferences found with an immunochemical drug test performed during a workplace control. During the period 1993-2003 more than 200,000 urine samples from workers were examined by the Italian Air Force. Samples were screened for drugs of abuse (opiates, cocaine, cannab...

journal_title：Clinical chemistry and laboratory medicine

authors： De Giovanni N,Fucci N

更新日期：2006-01-01 00:00:00

abstract：:Since serum and plasma D-dimer concentrations correlate very well, we evaluated the comparability of other haemostasis activation markers in plasma and serum. Prothrombin fragment F1+2, fibrin monomer and D-dimer concentrations were measured with commercially available immunoassays in serum and plasma. Serum to plasma...

journal_title：Clinical chemistry and laboratory medicine

authors： Korte W,Riesen WF

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The presence of preanalytical mistakes (PM) in samples from primary care centres (PCC) is a widely studied topic. Different correcting strategies have been proposed, with variable success. We planned a series of multidisciplinary sessions for clinical update, with the aim to decrease PM rates in samples from...

journal_title：Clinical chemistry and laboratory medicine

authors： Romero A,Gómez-Salgado J,Gómez-Fernández JA,Cobos A,Ruiz-Frutos C

更新日期：2017-10-26 00:00:00

abstract：BACKGROUND:Chagas disease is endemic in Latin America, affecting 16-18 million people with more than 100 million exposed to risk of infection. Its etiological agent is Trypanosoma cruzi. To date, benznidazole is the only treatment of Chagas disease available in Europe. METHODS:A high-performance reversed-phase isocrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Guerrero L,Pinazo MJ,Posada E,Gascón J,Ribas J,Soy D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:EML4-ALK fusion oncogene has emerged as a novel molecular target in non-small cell lung cancer (NSCLC). Although break-apart fluorescent in situ hybridization (FISH) is the standard method for diagnosis, it is expensive, not readily available and sometimes difficult to interpret. In addition, ALK immunohisto...

journal_title：Clinical chemistry and laboratory medicine

authors： Rho JK,Lee H,Park CS,Choi CM,Lee JC

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Risk prediction algorithms for coronary heart disease (CHD) are recommended for clinical use. However, their predictive ability remains modest and the inclusion of genetic risk may improve their performance. METHODS:QRISK2 was used to assess CHD risk using conventional risk factors (CRFs). The performance o...

journal_title：Clinical chemistry and laboratory medicine

authors： Beaney KE,Cooper JA,Drenos F,Humphries SE

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively contain RNA (small RNAs and mRNAs) and harbor unique subset of proteins, r...

journal_title：Clinical chemistry and laboratory medicine

authors： Channavajjhala SK,Rossato M,Morandini F,Castagna A,Pizzolo F,Bazzoni F,Olivieri O

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The aim was to investigate whether first trimester glycodelin and angiopoietin-2 can predict small-for-gestational age (SGA) at delivery, individually or in combination. METHODS:In this case-control study we measured glycodelin and angiopoietin-2 on serum from 170 singleton pregnant women delivering SGA neo...

journal_title：Clinical chemistry and laboratory medicine

authors： Hansen YB,Myrhøj V,Jørgensen FS,Sørensen S

更新日期：2016-09-01 00:00:00