Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application.

abstract：BACKGROUND:Several drugs may affect the diagnosis of brain death by depressing the electroencephalographic signal. Serum levels of these drugs must be below their respective therapeutic ranges. METHODS:A high performance liquid chromatography-based fast and simple method was developed for determination of thiopentone,...

journal_title：Clinical chemistry and laboratory medicine

authors： Meinitzer A,Kalcher K,Gartner G,Halwachs-Baumann G,März W,Stettin M

更新日期：2008-01-01 00:00:00

abstract：Objectives:Monoclonal immunoglobulins can cause interference in many laboratory analyses. During a 4 month period we observed seven patients with monoclonal disease and falsely extremely elevated 25-hydroxyvitamin D (25(OH)D) results above 160 ng/mL (>400 nmol/L) measured using an immunoassay from Abbott Diagnostics. B...

journal_title：Clinical chemistry and laboratory medicine

authors： Hager HB,Bolstad N,Warren DJ,Ness MV,Seierstad B,Lindberg M

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:Quantification of glycated hemoglobin (HbA1c) is a challenge in patients with hemoglobin (Hb) variants. We evaluated the impact of various Hb variants on five routine HbA1c assays by comparing with the IFCC reference measurement procedure (RMP). METHODS:Whole blood samples showing warning flags or no result...

journal_title：Clinical chemistry and laboratory medicine

authors： Yun YM,Ji M,Ko DH,Chun S,Kwon GC,Lee K,Song SH,Seong MW,Park SS,Song J

更新日期：2017-07-26 00:00:00

abstract：Objectives:The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally. The laboratory diagnosis of SARS-CoV-2 infection has relied on nucleic acid testing; however, it has some limitations, such as low throughput and high rates of false negatives. Tests of higher sensitivit...

journal_title：Clinical chemistry and laboratory medicine

authors： Qian C,Zhou M,Cheng F,Lin X,Gong Y,Xie X,Li P,Li Z,Zhang P,Liu Z,Hu F,Wang Y,Li Q,Zhu Y,Duan G,Xing Y,Song H,Xu W,Liu BF,Xia F

更新日期：2020-07-15 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is unclear. We and others have reported that homocysteine (Hcy) is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apoA-I) in patie...

journal_title：Clinical chemistry and laboratory medicine

authors： Liao D,Yang X,Wang H

更新日期：2007-01-01 00:00:00

abstract：:Since serum and plasma D-dimer concentrations correlate very well, we evaluated the comparability of other haemostasis activation markers in plasma and serum. Prothrombin fragment F1+2, fibrin monomer and D-dimer concentrations were measured with commercially available immunoassays in serum and plasma. Serum to plasma...

journal_title：Clinical chemistry and laboratory medicine

authors： Korte W,Riesen WF

更新日期：2001-07-01 00:00:00

abstract：:In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for regist...

journal_title：Clinical chemistry and laboratory medicine

authors： Rizos D,Karababa P,Nikolou C,Sarandakou A,Panagiotakis O,Ferderigou A,Haliassos A,Makris K,Psarra K,Bairaktari E,Spyropoulou P,Galiatsatos N,Trakas N,Seferiadis K,Greek National Clinical Chemistry Registration Commission.

更新日期：2011-08-30 00:00:00

abstract：BACKGROUND:Interleukins, interferons and oxidative DNA products are important biomarkers assessing the inflammations and tissue damages caused by toxic materials in the body. We tried to evaluate distributions, reference values and age related changes of blood levels of inflammatory cytokines, C-reactive protein (CRP),...

journal_title：Clinical chemistry and laboratory medicine

authors： Murase T,Kitamura H,Kochi T,Terunuma N,Kurosaki S,Hata K,Yanagi N,Uchino B,Kitahara K,Morimoto Y,Kasai H,Sasaki T,Ogami A,Higashi T

更新日期：2013-02-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS:In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) dif...

journal_title：Clinical chemistry and laboratory medicine

authors： Kim HN,Hur M,Kim H,Kim SW,Moon HW,Yun YM

更新日期：2017-11-27 00:00:00

abstract：:Cytokines are key mediators in cell regulation and communication. The concentration of these proteins can rapidly and importantly increase during severe clinical situations. However, current techniques are not adapted to stat measurement, thus making their clinical use limited. In this context, the commercialization o...

journal_title：Clinical chemistry and laboratory medicine

authors： Berthier F,Lambert C,Genin C,Bienvenu J

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The European Directive 98/79/EC on in-vitro diagnostic medical devices (IVDs) regulates IVD marketing practices and post-market surveillance. IVD manufacturers have to inform the responsible Competent Authorities of any issues. In Germany, the Federal Institute for Drugs and Medical Devices (BfArM) is respon...

journal_title：Clinical chemistry and laboratory medicine

authors： Siekmeier R,Lütz J

更新日期：2007-01-01 00:00:00

abstract：:Carbohydrate-deficient transferrin (CDT) is a descriptive term used for a temporary change in the transferrin glycosylation profile caused by alcohol, and used as a biomarker of chronic high alcohol consumption. The use of an array of methods for measurement of CDT in various absolute or relative amounts, and sometime...

journal_title：Clinical chemistry and laboratory medicine

authors： Helander A,Wielders JP,Jeppsson JO,Weykamp C,Siebelder C,Anton RF,Schellenberg F,Whitfield JB,IFCC Working Group on Standardization of Carbohydrate-Deficient Transferrin (WG-CDT).

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Insulin-like growth factors (IGFs) are believed to be important in brain development and repair following neuronal damage. It is also speculated that IGFs are involved in the association of foetal and pre-adult growth with schizophrenia (SZ). METHODS:The aim of this study was to assess levels of IGF-I, IGF-...

journal_title：Clinical chemistry and laboratory medicine

authors： Akanji AO,Ohaeri JU,Al-Shammri SA,Fatania HR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cardiac troponin T (cTnT) has been reported to be a predictor of stroke outcome. We hypothesized that the high-sensitivity cTnT (hs-cTnT) assay is superior to its previous assay generation for stroke outcome prediction. METHODS:cTnT was measured on emergency department admission in 60 consecutive patients (...

journal_title：Clinical chemistry and laboratory medicine

authors： Furtner M,Ploner T,Hammerer-Lercher A,Pechlaner R,Mair J

更新日期：2012-11-01 00:00:00

abstract：:Over the past decades, the randomized controlled trial has entered an era of continuous improvement and has gradually become accepted as the most effective way of determining the relative efficacy and toxicity of new therapies because it controls for placebo and time effects. However, even sensitive and properly desig...

journal_title：Clinical chemistry and laboratory medicine

authors： Cleophas TJ

更新日期：1999-11-01 00:00:00

abstract：:Introduction Element-tagged immunoassay coupled with inductively coupled plasma-mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis in clinical detection; however, a systematic evaluation with the standard guidelines of the assay is needed to ensure its performance meets the re...

journal_title：Clinical chemistry and laboratory medicine

authors： Jiang W,Sun G,Wen X,Men S,Cui W,Jing M,Jia X,Hu Z,Pu D,Zhang S,Yuan X,Liu X,Zhang X,Wang C

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:Rivaroxaban, a direct Xa inhibitor, is one of the new oral antithrombotic agents for which laboratory monitoring is thought to be unnecessary in most cases due to predictable pharmacokinetics. Circumstances are conceivable, however, in which reliable laboratory testing of Rivaroxaban is desirable. The aim of...

journal_title：Clinical chemistry and laboratory medicine

authors： Molenaar PJ,Dinkelaar J,Leyte A

更新日期：2012-10-01 00:00:00

abstract：:Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The i...

journal_title：Clinical chemistry and laboratory medicine

authors： Hong YJ,Lee JK,Lee GH,Hong SI

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Haemoglobin (Hb) variants are well-known factors interfering with accurate HbA1c testing. This report describes two novel Hb variants leading to inappropriate quantification of HbA1c by ion-exchange chromatography. METHODS:Glycated forms of novel Hb variants were recognised in the blood of two patients with...

journal_title：Clinical chemistry and laboratory medicine

authors： Bots M,Stroobants AK,Delzenne B,Soeters MR,de Vries JE,Weykamp CW,Norg RJ,Veldthuis M,Zwieten Rv

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) is an incurable and difficult to diagnose condition. While high sensitive C-reactive protein (CRP) remains the best biochemical marker, we evaluated the diagnostic usefulness of lipid peroxidation indices. METHODS:Malondialdehyde/thiobarbituric acid-reactive substances (MDA/TBARS), pero...

journal_title：Clinical chemistry and laboratory medicine

authors： Boehm D,Krzystek-Korpacka M,Neubauer K,Matusiewicz M,Paradowski L,Gamian A

更新日期：2012-03-03 00:00:00

abstract：BACKGROUND:Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study ...

journal_title：Clinical chemistry and laboratory medicine

authors： Gojkovic T,Vladimirov S,Spasojevic-Kalimanovska V,Zeljkovic A,Vekic J,Kalimanovska-Ostric D,Djuricic I,Sobajic S,Jelic-Ivanovic Z

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The aim of the study was to develop a method for sweat chloride (Cl) quantification using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to present to the Joint Committee for Traceability in Laboratory Medicine (JCTLM) as a candidate reference method for the diagnosis of cystic fibrosis (CF). METHODS...

journal_title：Clinical chemistry and laboratory medicine

authors： Collie JT,Massie RJ,Jones OA,Morrison PD,Greaves RF

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Despite remarkable advances in technology and laboratory automation, results of laboratory testing still suffer from a high degree of preanalytical variability. Although there is no definitive evidence, the use of small-gauge needles for venipuncture is usually discouraged to reduce the chance of producing u...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Salvagno GL,Montagnana M,Brocco G,Cesare Guidi G

更新日期：2006-01-01 00:00:00

abstract：:The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to c...

journal_title：Clinical chemistry and laboratory medicine

authors： Rayana MC,Burnett RW,Covington AK,D'Orazio P,Fogh-Andersen N,Jacobs E,Kataky R,Külpmann WR,Kuwa K,Larsson L,Lewenstam A,Maas AH,Mager G,Naskalski JW,Okorodudu AO,Ritter C,St John A,International Federation of Clinical C

更新日期：2006-01-01 00:00:00

abstract：:Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight cytoplasmic protein and present abundantly in the myocardium. When the myocardium is injured, as in the case of myocardial infarction, low molecular weight cytoplasmic proteins including H-FABP are released into the circulation and H-FABP is dete...

journal_title：Clinical chemistry and laboratory medicine

authors： Okamoto F,Sohmiya K,Ohkaru Y,Kawamura K,Asayama K,Kimura H,Nishimura S,Ishii H,Sunahara N,Tanaka T

更新日期：2000-03-01 00:00:00

abstract：:An alcohol-associated change in the serum transferrin glycoform pattern, carbohydrate-deficient transferrin (CDT), is used as a biomarker of chronic moderate to heavy alcohol consumption. A current limitation in CDT analysis is the lack of standardization, which hampers clinical and analytical comparison between studi...

journal_title：Clinical chemistry and laboratory medicine

authors： Jeppsson JO,Arndt T,Schellenberg F,Wielders JP,Anton RF,Whitfield JB,Helander A,International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardization of Carbohydrate-deficient Transferin (IFCC-WG-CDT).

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There is a certain difference in opinion regarding the optimal choice of housekeeping genes used as normalization factors in gene expression analysis. We have therefore examined the suitability of three housekeeping genes, hypoxanthine phosphoribosyl transferase, beta-glucuronidase and beta2-micro-globulin, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kågedal B,Farnebäck M,Håkansson A,Gustafsson B,Håkansson L

更新日期：2007-01-01 00:00:00

abstract：:Diabesity, that is to say, obesity-dependent diabetes, has emerged as a major public health problem. Though diabesity is basically explained by insulin resistance and pancreatic beta cell dysfunction, new paradigms have evolved to explain these alterations in the context of the modern epidemics of obesity and diabetes...

journal_title：Clinical chemistry and laboratory medicine

authors： Schmidt MI,Duncan BB

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The possible effects of the uncoupling protein-1 (UCP-1) gene -3826A/G polymorphism on hypertension (HT) have yet to be elucidated. METHODS:A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the -3826A/G ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kotani K,Sakane N,Saiga K,Tsuzaki K,Shimohiro H,Tabata M,Kurozawa Y

更新日期：2007-01-01 00:00:00