Measuring Rivaroxaban in a clinical laboratory setting, using common coagulation assays, Xa inhibition and thrombin generation.

abstract：BACKGROUND:Haemoglobin (Hb) variants are well-known factors interfering with accurate HbA1c testing. This report describes two novel Hb variants leading to inappropriate quantification of HbA1c by ion-exchange chromatography. METHODS:Glycated forms of novel Hb variants were recognised in the blood of two patients with...

journal_title：Clinical chemistry and laboratory medicine

authors： Bots M,Stroobants AK,Delzenne B,Soeters MR,de Vries JE,Weykamp CW,Norg RJ,Veldthuis M,Zwieten Rv

更新日期：2015-08-01 00:00:00

abstract：:Cardiovascular risk is associated with high lipoprotein(a) (Lp(a)) concentrations and low molecular weight apolipoprotein(a) (apo(a)) isoforms. We studied the relationship between these two biological parameters, particularly in subjects expressing two apo(a) isoforms. Plasma Lp(a) was measured by immunonephelometry i...

journal_title：Clinical chemistry and laboratory medicine

authors： Alaoui M,Merle C,Garnotel R,Jolly D,Durlach V,Gillery P

更新日期：2003-05-01 00:00:00

abstract：:It is well-established that more than 8% of patients examined for vitamin B12 deficiency unexpectedly have increased plasma levels of the vitamin, but so far there are no guidelines for the clinical interpretation of such findings. In this review, we summarise known associations between high plasma cobalamin and disea...

journal_title：Clinical chemistry and laboratory medicine

authors： Arendt JF,Nexo E

更新日期：2013-03-01 00:00:00

abstract：:Prolidases I and II were highly purified from human erythrocytes. The effects of various amino acids, MnCl2 and mercaptoethanol, on these two enzymes were investigated. Normal prolidase II was very labile in the absence of MnCl2 or mercaptoethanol. The activity of prolidase II was maintained at about 76% by pre-incuba...

journal_title：Clinical chemistry and laboratory medicine

authors： Nakayama K,Awata S,Zhang J,Kaba H,Manabe M,Kodama H

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Fibrinogen-based clot firmness is reported as the maximum amplitude (MA) when using the citrated functional fibrinogen (CFF) assay in thrombelastography (TEG), and as the maximum clot firmness (MCF) together with several clot amplitude parameters when using the FIBTEM assay in thromboelastometry (ROTEM). Con...

journal_title：Clinical chemistry and laboratory medicine

authors： Prüller F,Münch A,Preininger A,Raggam RB,Grinschgl Y,Krumnikl J,Toller W,Metzler H,Mahla E,Mangge H

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Apolipoprotein A-I gene (APOA1) polymorphisms have been associated with variations in serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol. We have investigated whether APOA1 common variants are also associated with variations in basal triglyceride serum concentrations and resp...

journal_title：Clinical chemistry and laboratory medicine

authors： Sorkin SC,Forestiero FJ,Hirata MH,Guzmán EC,Cavalli SA,Bertolami MC,Salazar LA,Hirata RD

更新日期：2005-01-01 00:00:00

abstract：:The annual inter- and intra-individual biological variation, including the circannual rhythmic variation, of the serum concentrations of magnesium and ionized calcium has been investigated in a group of 51 apparently healthy volunteers. Venous blood specimens were collected on intervals of once a month within a one-ye...

journal_title：Clinical chemistry and laboratory medicine

authors： Valero-Politi J,Ginard-Salvá M,González-Alba JM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The Intermountain Mortality Risk Score (IMRS), a sex-specific mortality-prediction metric, has proven to be effective in various populations. IMRS is comprised of the complete blood count (CBC), basic metabolic panel (BMP), and age. Whether the addition of factors from the comprehensive metabolic panel (CMP)...

journal_title：Clinical chemistry and laboratory medicine

authors： May HT,Anderson JL,Muhlestein JB,Lappé DL,Ronnow BS,Horne BD

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The possible effects of the uncoupling protein-1 (UCP-1) gene -3826A/G polymorphism on hypertension (HT) have yet to be elucidated. METHODS:A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the -3826A/G ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kotani K,Sakane N,Saiga K,Tsuzaki K,Shimohiro H,Tabata M,Kurozawa Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to investigate serum lactate dehydrogenase (LD) levels in patients with silicosis due to denim sandblasting (SDDS) and also to investigate possible correlations between serum LD levels and the degree of radiological extent of disease (RED) and pulmonary function tests. METHO...

journal_title：Clinical chemistry and laboratory medicine

authors： Deniz O,Gumus S,Ors F,Yaman H,Battal B,Karaman B,Acikel CH,Ucar E,Cakir E,Tozkoparan E,Bilgic H

更新日期：2012-01-31 00:00:00

abstract：:Inflammatory bowel diseases (IBDs), which comprise the two major clinical subtypes, Crohn's disease and ulcerative colitis, incur high morbidity and potential mortality. The present study reviews data on the pathogenesis and diagnosis of IBDs. The pathogenesis depends on complex interactions between susceptibility gen...

journal_title：Clinical chemistry and laboratory medicine

authors： Basso D,Zambon CF,Plebani M

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Efficient laboratory service is the cornerstone of modern health care systems. Scientific innovations have contributed to substantial improvements in the field of laboratory science, but errors still prevail. These errors are classified as preanalytical, analytical and postanalytical, depending upon the time...

journal_title：Clinical chemistry and laboratory medicine

authors： Goswami B,Singh B,Chawla R,Mallika V

更新日期：2010-01-01 00:00:00

abstract：:Age-related variation of the urinary excretion of amino acids has been widely reported. Instead of the conventional reference intervals, continuous reference limits might be a more practical approach during periods of rapid changes such as infancy or childhood. Regression-based reference limits have been produced for ...

journal_title：Clinical chemistry and laboratory medicine

authors： Venta R,Prieto B,Alvarez FV

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Iodine requirements increase during pregnancy and previous studies have reported the inadequate iodine status of pregnant women in areas that have achieved iodine sufficiency in the general population. We examined the urinary iodine (UI) concentrations of pregnant women in Ukraine, where the iodine status is...

journal_title：Clinical chemistry and laboratory medicine

authors： Sekitani Y,Hayashida N,Takahashi J,Kozlovsky AA,Rudnitskiy S,Petrova A,Gutevych OK,Chorniy SA,Yamashita S,Takamura N

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The discovery of mutations in the epidermal growth factor receptor gene (EGFR) related to the clinical response to tyrosine kinase inhibitors, has transformed the management of non-small cell lung cancer (NSCLC). Several methods have been developed for determination of mutations in EGFR, with different sensi...

journal_title：Clinical chemistry and laboratory medicine

authors： Martínez-Carretero C,Pascual FI,Rus A,Bernardo I

更新日期：2017-10-26 00:00:00

abstract：:Background The present study was undertaken to evaluate the clinical impact of a thyroglobulin (Tg) minirecovery test (Tg-mRec) in a large series of differentiated thyroid carcinoma (DTC) patients treated and monitored homogeneously in a tertiary referral center. Methods Included were 1120 serum samples from 798 DTC p...

journal_title：Clinical chemistry and laboratory medicine

authors： Giovanella L,Verburg FA,Trimboli P,Imperiali M,Keller F,Ceriani L

更新日期：2019-07-26 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：:Background The aim of this study was to evaluate the diagnostic performance of cerebrospinal fluid (CSF) free light chains (FLCs) in the diagnosis of Lyme neuroborreliosis (LNB). Methods Serum and CSF levels of κ- and λ-FLC, albumin and total concentration of immunoglobulin M (IgM) were determined together with CSF ch...

journal_title：Clinical chemistry and laboratory medicine

authors： Tjernberg I,Johansson M,Henningsson AJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:The arginine derivatives asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) interfere with endothelial nitric oxide synthesis. Plasma ADMA and SDMA have been shown to be risk factors for cardiovascular disease and/or kidney function deterioration in a variety of patient populations. ME...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang S,Vicente FB,Miller A,Brooks ER,Price HE,Smith FA

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Validation of blood collection tubes are important to determine the role of different collection tubes which influence the assurance of laboratory results. We compared two different tubes (Improvacuter™ and Becton Dickinson [BD] Vacutainer™) and investigated the effect of gel and storage time in comparison w...

journal_title：Clinical chemistry and laboratory medicine

authors： Zungun C,Yılmaz FM,Boru EG,Topcuoglu C

更新日期：2015-02-01 00:00:00

abstract：:The erythrocyte sedimentation rate (ESR), now more appropriately referred to as the "length of sedimentation reaction in blood (LSRB)", remains the most widely used laboratory test for monitoring the course of infections, inflammatory diseases and some types of cancer. Thanks to the several recently developed methods ...

journal_title：Clinical chemistry and laboratory medicine

authors： Piva E,Fassina P,Plebani M

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:alpha-Thalassemia is a worldwide disease and considered to be a major public health problem in countries within the so-called thalassemia belt. The complex genetics of alpha-thalassemias requires diagnostic methods with the capacity to screen rapidly and accurately for common causative mutations. METHODS:We...

journal_title：Clinical chemistry and laboratory medicine

authors： Puehringer H,Najmabadi H,Law HY,Krugluger W,Viprakasit V,Pissard S,Baysal E,Taher A,Farra C,Al-Ali A,Al-Ateeq S,Oberkanins C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:POEMS syndrome is defined by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes. The vascular endothelial growth factor (VEGF) appears to play a key role in the pathogenesis of the syndrome, and its concentrations are deemed to correlate to disease activity. The aim of the p...

journal_title：Clinical chemistry and laboratory medicine

authors： Altinier S,Proko K,Zaninotto M,Ciubotaru D,Seguso M,Varagnolo M,Lessi F,Briani C,Adami F,Plebani M

更新日期：2016-06-01 00:00:00

abstract：:Activated protein C (APC), a natural anticoagulant, is formed from protein C by the action of the thrombin-thrombomodulin (TM) complex on the endothelial cell surface. Endothelial protein C receptor augments the activation of protein C by the thrombin/TM system. APC inactivates the activated form of coagulation factor...

journal_title：Clinical chemistry and laboratory medicine

authors： Okajima K

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:It has been proposed that only anti-thyroid-peroxidase (TPOAb) and not anti-thyroglobulin (TgAb) antibodies should be assayed in the diagnosis of autoimmune thyroid disease (AITD). METHODS:We analyzed the thyroid autoantibody profile with a multiplex bead array system, which allows simultaneous measurement ...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,Villalta D,Kodermaz G,Bagnasco M,Tonutti E,Bizzaro N

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In analogy with other areas of laboratory diagnostics, the pre-analytical phase is the leading source of variability also in urinalysis. We carried out a multicentric study for comparing results obtained from first-voided and mid-stream urine samples. METHODS:Each of the six hospital-based clinical laborato...

journal_title：Clinical chemistry and laboratory medicine

authors： Manoni F,Gessoni G,Alessio MG,Caleffi A,Saccani G,Silvestri MG,Poz D,Ercolin M,Tinello A,Valverde S,Ottomano C,Lippi G

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:The clinical relevance of chromogranin A (CgA) concentrations depends on the analytical performance of the assay. The goal of the present study was to define the clinical involvements in CgA calibration models by evaluating the confidence intervals (CIs) for values from patients who were undergoing monitorin...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Marano G,Ciardi L,Vendramin C,Bongo AS,Bellomo G,Boracchi P,Biganzoli EM

更新日期：2009-01-01 00:00:00

abstract：:Acute intestinal ischemic injury (i3) is a life-threatening condition with disastrous prognosis, which is currently difficult to diagnose at the early stages of the disease; a rapid diagnosis is mandatory to avoid irreversible ischemia, extensive bowel resection, sepsis and death. The overlapping protein expression of...

journal_title：Clinical chemistry and laboratory medicine

authors： Peoc'h K,Nuzzo A,Guedj K,Paugam C,Corcos O

更新日期：2018-02-23 00:00:00

abstract：:Although affinity and kinetic measurements on their own provide useful information regarding the suitability of antibodies for various immunoassays, a thermodynamic analysis provices additional information that throws light on the molecular forces at work in the antigen-antibody interaction. It may then be possible to...

journal_title：Clinical chemistry and laboratory medicine

authors： Van Regenmortel MH

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:After the re-introduction of ImmunoCAP® ISAC sIgE 112 on the market, we undertook a study to evaluate the performance of this multiplex-based immunoassay for IgE measurements to allergen components. METHODS:The study was carried out at 22 European and one South African site. Microarrays from different batch...

journal_title：Clinical chemistry and laboratory medicine

authors： van Hage M,Schmid-Grendelmeier P,Skevaki C,Plebani M,Canonica W,Kleine-Tebbe J,Nystrand M,Jafari-Mamaghani M,Jakob T

更新日期：2017-03-01 00:00:00