Determination of the length of sedimentation reaction (erythrocyte sedimentation rate) in non-anticoagulated blood with the Microtest 1.

abstract：:Intake of drugs may influence the interpretation of laboratory test results. Knowledge and correct interpretation of possible drug-laboratory test interactions (DLTIs) is important for physicians, pharmacists and laboratory specialists. Laboratory results may be affected by analytical or physiological effects of medic...

journal_title：Clinical chemistry and laboratory medicine

authors： van Balveren JA,Verboeket-van de Venne WPHG,Erdem-Eraslan L,de Graaf AJ,Loot AE,Musson REA,Oosterhuis WP,Schuijt MP,van der Sijs H,Verheul RJ,de Wolf HK,Kusters R,Hoedemakers RMJ,Dutch Society for Clinical Chemistry and Laborat

更新日期：2018-11-27 00:00:00

abstract：:Microsatellite typing is frequently used in disease diagnosis and in genetic association studies. Inter-study consistency and comparability is essential in both applications. In this study, we show that the interlaboratory comparison of microsatellite sizes is often discrepant and misleading. This is a matter of great...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossouw M,Warren R,Hoal EG

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Mechanical manipulation of the prostate is a generally accepted interfering factor for the measurement of prostate-specific antigen (PSA). However, only few studies have focused on common daily mechanical manipulations, such as bicycle riding. Furthermore, physical exercise is also supposed to modulate PSA seru...

journal_title：Clinical chemistry and laboratory medicine

authors： Herrmann M,Scharhag J,Sand-Hill M,Kindermann W,Herrmann W

更新日期：2004-03-01 00:00:00

abstract：:Testing for the diagnosis of acute myocardial infarction and other diseases included in the spectrum of the "acute coronary syndrome" is rapidly changing from the traditional enzymatic assays to mass measurement of more specific and sensitive markers (cardiac troponins, CK-MB and myoglobin). Several questions have ari...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M,Zaninotto M

更新日期：1999-11-01 00:00:00

abstract：:Angiogenesis is a crucial process in tissue remodeling during growth, both in the embryo and the adult. In our study we concentrated on the direct effect of beta-carotene on human umbilical cord originating from endothelial progenitor cells (EPCs). beta-Carotene uptake by EPCs was measured using a HPLC method. The det...

journal_title：Clinical chemistry and laboratory medicine

authors： Kieć-Wilk B,Polus A,Grzybowska J,Mikołajczyk M,Hartwich J,Pryjma J,Skrzeczyńska J,Dembińska-Kieć A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The Cystic Fibrosis European Network, coordinated from within the Katholieke Universiteit Leuven, is the provider of the European cystic fibrosis external quality assessment (EQA) scheme. The network aimed to seek feedback from laboratories that participated in the cystic fibrosis scheme in order to improve ...

journal_title：Clinical chemistry and laboratory medicine

authors： Berwouts S,Dequeker E

更新日期：2011-08-01 00:00:00

abstract：:The measurement of glycated haemoglobin has become centrally important in the monitoring of glycaemic control in the patient with diabetes. A number of analytical techniques have been described to measure this important haemoglobin fraction, and the fraction measured depends on the technique used; this has resulted in...

journal_title：Clinical chemistry and laboratory medicine

authors： John WG

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF/MS), a laboratory-friendly technique, is used to identify biomarkers for cancer. The aim of the present study was to explore the application of SELDI proteomic patterns in serum for distinguishing between cases of pa...

journal_title：Clinical chemistry and laboratory medicine

authors： Navaglia F,Fogar P,Basso D,Greco E,Padoan A,Tonidandel L,Fadi E,Zambon CF,Bozzato D,Moz S,Seraglia R,Pedrazzoli S,Plebani M

更新日期：2009-01-01 00:00:00

abstract：:Progression of atherosclerosis is currently believed to involve interactions between leukocytes and vascular endothelium. Epidemiological risk factors for atherosclerosis such as hypertension and smoking are known to cause endothelial dysfunction, which is an early event in the atherosclerotic process; they also may b...

journal_title：Clinical chemistry and laboratory medicine

authors： Mazzone A,Cusa C,Mazzucchelli I,Vezzoli M,Ottini E,Ghio S,Tossini G,Pacifici R,Zuccaro P

更新日期：2001-09-01 00:00:00

abstract：:Background While quantitation methods for small-molecule and tryptic peptide bottom-up mass spectrometry (MS) have been well defined, quantitation methods for top-down or middle-up MS approaches have not been as well defined. Therapeutic monoclonal antibodies (t-mAbs) are a group of proteins that can be used to both d...

journal_title：Clinical chemistry and laboratory medicine

authors： Cradic KW,Ladwig PM,Rivard AL,Katrangi W,Wintgens KF,Willrich MAV

更新日期：2020-06-25 00:00:00

abstract：:Biochemical measurements in "special fluids" are complicated with the problem of reference intervals. Reference intervals are difficult to establish for these types of samples since they are usually only collected in patients with clinical suspicion of disease. Determination of neurotransmitter metabolites in cerebros...

journal_title：Clinical chemistry and laboratory medicine

authors： Dhondt JL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative data and secondarily to evaluate the potential utility of GDF-15 in DKD using Roche Diagnostics ele...

journal_title：Clinical chemistry and laboratory medicine

authors： Hamon SM,Griffin TP,Islam MN,Wall D,Griffin MD,O'Shea PM

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:Laboratory reference intervals are not necessarily reflecting the range in the background population. This study compared creatine kinase (CK) reference intervals calculated from a large sample from a Norwegian population with those elaborated by the Nordic Reference Interval Project (NORIP). It also assesse...

journal_title：Clinical chemistry and laboratory medicine

authors： Lilleng H,Johnsen SH,Wilsgaard T,Bekkelund SI

更新日期：2011-11-10 00:00:00

abstract：BACKGROUND:An E670G polymorphism of the exon 12 of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was recently found to be associated with increased plasma low-density lipoprotein cholesterol (LDL-C) levels and severity of coronary atherosclerosis. This case-control study tested for a possible link betw...

journal_title：Clinical chemistry and laboratory medicine

authors： Hsu LA,Teng MS,Ko YL,Chang CJ,Wu S,Wang CL,Hu CF

更新日期：2009-01-01 00:00:00

abstract：:Complexity, cost, and content are three important factors that can impede translation of clinical protein mass spectrometry (MS) tests at a larger scale. Complexity stems from the many components/steps involved in bottom-up protein MS workflows, making them significantly more complicated than enzymatic immunoassays (E...

journal_title：Clinical chemistry and laboratory medicine

authors： Nedelkov D,Hu Y

更新日期：2020-06-25 00:00:00

abstract：:There is no comprehensive study on the stability of coagulation analytes in plasma. We therefore determined the influence of storage time and temperature on prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, factors V and VIII, antithrombin III, protein C and S in plasma from 20 health...

journal_title：Clinical chemistry and laboratory medicine

authors： Heil W,Grunewald R,Amend M,Heins M

更新日期：1998-06-01 00:00:00

abstract：Background:Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based assays are employed in more and more clinical laboratories to quantify steroids. The steroid quantification by LC-MS/MS shows great value in screening or diagnosing endocrine disorders; however, the number of functional steroids included in the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang Z,Wang H,Peng Y,Chen F,Zhao L,Li X,Qin J,Li Q,Wang B,Pan B,Guo W

更新日期：2020-02-21 00:00:00

abstract：:This paper reports on a pilot external quality assessment scheme for bone markers including serum bone alkaline phosphatase and procollagen 1-carboxy terminal propeptide together with urine deoxypyridinoline, N- and C-telopeptides. The data shows poor numerical agreement between commercial assays, between-laboratory i...

journal_title：Clinical chemistry and laboratory medicine

authors： Whitham KM,Milford-Ward A

更新日期：2000-11-01 00:00:00

abstract：Objectives:The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally. The laboratory diagnosis of SARS-CoV-2 infection has relied on nucleic acid testing; however, it has some limitations, such as low throughput and high rates of false negatives. Tests of higher sensitivit...

journal_title：Clinical chemistry and laboratory medicine

authors： Qian C,Zhou M,Cheng F,Lin X,Gong Y,Xie X,Li P,Li Z,Zhang P,Liu Z,Hu F,Wang Y,Li Q,Zhu Y,Duan G,Xing Y,Song H,Xu W,Liu BF,Xia F

更新日期：2020-07-15 00:00:00

abstract：:A questionnaire to assess knowledge of the expected elevation in serum K measurement with different grades of hemolysis was administered to medical technologists working in biochemistry laboratories, hospital physicians and nurses. The questions involved different grades of hemolysis (mild, 1.0, moderate, 2.5 and seve...

journal_title：Clinical chemistry and laboratory medicine

authors： Hawkins RC

更新日期：2005-01-01 00:00:00

abstract：:Background Intravascular hemolysis and in vitro hemolysis are prevalent contributors to failed blood sample analysis in the routine hospital laboratory. Interferences by hemoglobin in spectrophotometric and certain enzyme activity assays is the major causative factor. Methods By exploiting the hemoglobin-binding prope...

journal_title：Clinical chemistry and laboratory medicine

authors： Sæderup KL,Revsholm J,Richardt PB,Christiansen SH,Hennig D,Moestrup SK,Graversen JH

更新日期：2019-10-25 00:00:00

abstract：BACKGROUND:With patients referred to emergency departments (EDs) for acute dyspnea, emergency physicians should consider all possible diagnoses and assess patients' risk stratification. Copeptin has been shown to have prognostic power for subsequent events, such as death and rehospitalization in patients admitted for d...

journal_title：Clinical chemistry and laboratory medicine

authors： Vetrone F,Santarelli S,Russo V,Lalle I,De Berardinis B,Magrini L,Di Stasio E,Salerno G,Cardelli P,Piccoli A,Codognotto M,Mion MM,Plebani M,Vettore G,Castello LM,Avanzi GC,Di Somma S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The aim of our study was to determine the frequency of anti-thyroid-stimulating hormone (TSH) receptor antibodies (TRAb) in Tunisian patients with Graves' disease (GD) and to compare the validity of TRAb to that of thyroperoxidase (TPO-Ab) and thyroglobulin antibodies (TG-Ab). METHODS:ELISA was used to dete...

journal_title：Clinical chemistry and laboratory medicine

authors： Mankaï A,Toumi D,Chadli-Chaieb M,Ghedira-Besbes L,Saad F,Ouertani M,Sfar H,Jeddi M,Chaieb L,Ghedira I

更新日期：2007-01-01 00:00:00

abstract：:Experimental and observational studies support a role of plasma homocysteine levels (tHcy) in coronary artery disease (CAD). In the GENICA (Genetic and Environmental factors In Coronary Atherosclerosis) study, we found that high tHcy predicted cardiovascular mortality in hypertensive, but not in normotensive, patients...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossi GP,Seccia TM,Pessina AC

更新日期：2007-01-01 00:00:00

abstract：:In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for regist...

journal_title：Clinical chemistry and laboratory medicine

authors： Rizos D,Karababa P,Nikolou C,Sarandakou A,Panagiotakis O,Ferderigou A,Haliassos A,Makris K,Psarra K,Bairaktari E,Spyropoulou P,Galiatsatos N,Trakas N,Seferiadis K,Greek National Clinical Chemistry Registration Commission.

更新日期：2011-08-30 00:00:00

abstract：:We evaluated the analytical performance of the Immulite 2000 immunoassay analyzer (Diagnostic Products Corporation, Los Angeles, USA) based on a new detection technology, electrochemical luminescence. The evaluated analytes were thyrotropin, triiodothyronine, free thyroxine, follitropin, lutropin, prolactin, cortisol,...

journal_title：Clinical chemistry and laboratory medicine

authors： Tello FL,Hernández DM

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:The handling of cerebrospinal fluid (CSF) affects the biomarker quantification used to diagnose Alzheimer's disease (AD). Only specialized centers can test for AD markers. The precise timing and freezing is required to correctly measure these biomarkers. Therefore, the effects of CSF storage temperature and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Klener J,Hofbauerová K,Bartoš A,Ríčný J,Rípová D,Kopecký V

更新日期：2014-05-01 00:00:00

abstract：:The annual inter- and intra-individual biological variation, including the circannual rhythmic variation, of the serum concentrations of magnesium and ionized calcium has been investigated in a group of 51 apparently healthy volunteers. Venous blood specimens were collected on intervals of once a month within a one-ye...

journal_title：Clinical chemistry and laboratory medicine

authors： Valero-Politi J,Ginard-Salvá M,González-Alba JM

更新日期：2001-01-01 00:00:00

abstract：:The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 af...

journal_title：Clinical chemistry and laboratory medicine

authors： Milani P,Valentini V,Ferraro G,Basset M,Russo F,Foli A,Palladini G,Merlini G

更新日期：2016-06-01 00:00:00

abstract：:Circulating blood platelets play a central role in the maintenance of hemostasis. They adhere to subendothelial extracellular matrix proteins that become exposed upon vessel wall damage, which is followed by platelet activation, further platelet recruitment, platelet aggregation and formation of an occlusive, or non-o...

journal_title：Clinical chemistry and laboratory medicine

authors： Provost P

更新日期：2017-05-01 00:00:00