Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD).

abstract：BACKGROUND:Metabolic syndrome is closely related to several disturbances in lipid and lipoprotein metabolism. The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications. METHODS:The study included 279 s...

journal_title：Clinical chemistry and laboratory medicine

authors： Sima A,Iordan A,Stancu C

更新日期：2007-01-01 00:00:00

abstract：:Severe thermal injury causes an immune dysfunction which includes a decrease of monocyte human leukocyte antigen DR (HLA-DR) expression. Interleukin-10 exerts a negative influence on this parameter in vitro. In this study we determined the prognostic value of reduced monocyte HLA-DR expression with regard to infectiou...

journal_title：Clinical chemistry and laboratory medicine

authors： Sachse C,Prigge M,Cramer G,Pallua N,Henkel E

更新日期：1999-03-01 00:00:00

abstract：:Human protein 1/Clara cell Mr 10,000 protein consists of two identical subunits of seventy amino acid residues each. In the present study, eight clones of monoclonal antibodies against native protein 1 were prepared and their respective epitopes were immunochemically and immunohistochemically characterized using nativ...

journal_title：Clinical chemistry and laboratory medicine

authors： Yamaguchi T,Yamada T,Okutani R,Shijubo N,Singh G,Itoh Y

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Mutations in the retina-specific ABC transporter (ABCA4) gene are associated with different types of macular degeneration, including Stargardt disease, cone-rod dystrophy, Fundus flavimaculatus, Retinitis pigmentosa and probably age-related macular degeneration. METHODS:Screening for mutations in the ABCA4 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stenirri S,Battistella S,Fermo I,Manitto MP,Martina E,Brancato R,Ferrari M,Cremonesi L

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The presence of fibronectin fragments has been observed in some inflammatory diseases and is believed to reflect tissue breakdown. In this study, possible fibronectin fragmentation and alterations in its domain and sialyl and fucosyl glycotope expressions were analyzed in amniotic fluids in relation to intra...

journal_title：Clinical chemistry and laboratory medicine

authors： Hirnle L,Katnik-Prastowska I

更新日期：2007-01-01 00:00:00

abstract：:Although prostate-specific antigen (PSA), or human kallikrein 3, is the most valuable tool available for the diagnosis and management of prostate cancer, as currently used it is insufficiently sensitive and specific for early detection or staging of the malignancy. Many new concepts have been introduced in order to op...

journal_title：Clinical chemistry and laboratory medicine

authors： Daher R,Beaini M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations. METHODS:We enrolled 101 women aged ≤56 years with a glomerular filtrat...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Pasqualetti S,Carnevale A,Panteghini M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Linezolid is the first synthetic compound of a new group of antimicrobials, the oxazolidinones, which inhibit protein synthesis. It shows a broad spectrum of activity against Gram positive organisms. With respect to its pharmacokinetics, linezolid shows a relatively high volume of distribution and good penet...

journal_title：Clinical chemistry and laboratory medicine

authors： Guerrero L,Martínez-Olondris P,Rigol M,Esperatti M,Esquinas C,Luque N,Piñer R,Torres A,Soy D

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The objective of the study was to find the incidence of hemolysis in samples transported through a pneumatic tube system (PTS) at different speeds. METHODS:This prospective observational study was done in three phases: "short distance and high speed (115 m at 3 m/s)", "long distance and high speed (225 m at...

journal_title：Clinical chemistry and laboratory medicine

authors： Tiwari AK,Pandey P,Dixit S,Raina V

更新日期：2011-11-10 00:00:00

abstract：BACKGROUND:The long noncoding RNAs (lncRNAs) have gradually been reported to be an important class of RNAs with pivotal roles in regulation of gene expression, and thus are involved in multitudinous human complex diseases. However, the biological functions and precise mechanisms of the majority of lncRNAs are still poo...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhuo Y,Zeng Q,Zhang P,Li G,Xie Q,Cheng Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:High-density lipoprotein (HDL) is believed to be protective against coronary heart disease (CHD). HDL is comprised of different subfractions. Of these, HDL 2b is believed to be the most important in preventing CHD. Current methods for HDL subfraction measurements are not standardized and often exhibit poor a...

journal_title：Clinical chemistry and laboratory medicine

authors： Yang DH,Konigshofer Y,Dike J,Chang E,Mueller O

更新日期：2010-06-01 00:00:00

abstract：:The aim of this study was to clarify the effects of anti-dsDNA antibodies on the titer and the nuclear staining pattern(s) in a fluorescent antinuclear antibody (FANA) assay using HEp-2 cells. Anti-dsDNA derived from 14 patients with systemic lupus erythematosus (SLE) was individually affinity-purified. The anti-dsDNA...

journal_title：Clinical chemistry and laboratory medicine

authors： Suzuki K,Kawamura M,Mineo M,Shinohara T,Kataharada K,Okada M,Takada K,Miyawaki S,Ohsuzu F

更新日期：2002-01-01 00:00:00

abstract：:The importance of proper consumption of dietary folate for human health has been highlighted by an extensive number of publications over several decades. Fortification of grain products with folic acid was initiated with the specific intent to prevent neural tube defects, and the scope of this endeavor is unique in th...

journal_title：Clinical chemistry and laboratory medicine

authors： Strickland KC,Krupenko NI,Krupenko SA

更新日期：2013-03-01 00:00:00

abstract：:The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several clinically important drugs. So far more than 50 different CYP2D6 allelic variants have been described, and thus there is an increased need for routine high-performance liquid chromatography (HPLC) methods for the evaluat...

journal_title：Clinical chemistry and laboratory medicine

authors： Dorado P,Berecz R,Cáceres MC,González I,Cobaleda J,Llerena A

更新日期：2005-01-01 00:00:00

abstract：:The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) formed a Task Force on the Application of Cardiac Bio-markers (TF-CB) in 2008, re-designated in 2018 as a committee (C-CB), to produce educational materials on cardiac biomarkers. Established in June 2017, definitive tables covering the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Collinson PO,Saenger AK,Apple FS,IFCC C-CB.

更新日期：2019-04-24 00:00:00

abstract：:This review evaluates the role of platelets in bleeding risk among patients with hematological disease and thrombocytopenia. Platelets are pivotal in primary hemostasis, and possess non-hemostatic properties involved in angiogenesis, tissue repair, inflammation and metastatis. Also, platelets safeguard vascular integr...

journal_title：Clinical chemistry and laboratory medicine

authors： Vinholt PJ

更新日期：2019-11-26 00:00:00

abstract：:Small dense low-density lipoproteins (LDLs) have been associated with coronary heart disease (CHD) and type 2 diabetes in previous studies. However, the significance of small dense LDLs as a coronary risk factor for subjects with type 2 diabetes remains unclear. We measured mean LDL particle diameter by gradient gel e...

journal_title：Clinical chemistry and laboratory medicine

authors： Yoon Y,Song J,Park HD,Park KU,Kim JQ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:There are several complementary English-language guidelines for the performance of the sweat chloride test. These guidelines also incorporate information for the collection of conductivity samples. However, recommendations for the measurement and reporting of sweat conductivity are less clear than for sweat ...

journal_title：Clinical chemistry and laboratory medicine

authors： Greaves RF,Jolly L,Massie J,Scott S,Wiley VC,Metz MP,Mackay RJ,Australasian Association of Clinical Biochemists Sweat Test Working Party in association with the Royal Australasian College of Pathologists Quality Assurance Programs.

更新日期：2018-03-28 00:00:00

abstract：Objectives:Monoclonal immunoglobulins can cause interference in many laboratory analyses. During a 4 month period we observed seven patients with monoclonal disease and falsely extremely elevated 25-hydroxyvitamin D (25(OH)D) results above 160 ng/mL (>400 nmol/L) measured using an immunoassay from Abbott Diagnostics. B...

journal_title：Clinical chemistry and laboratory medicine

authors： Hager HB,Bolstad N,Warren DJ,Ness MV,Seierstad B,Lindberg M

更新日期：2020-10-29 00:00:00

abstract：:Classical genetic studies involving the analysis of pedigrees and recurrence risk within families have defined the extent to which genetic factors contribute to the aetiology of multiple sclerosis. Limited progress has been made in identifying the number and topography of genetic loci contributing to susceptibility th...

journal_title：Clinical chemistry and laboratory medicine

authors： Compston A

更新日期：2000-02-01 00:00:00

abstract：:Phenylketonuria is an inherited metabolic disease, which is characterized by an increased level of serum phenylalanine. Quantitative measurement of phenylalanine in the serum of phenylketonuria patients is necessary to confirm the disease, and to distinguish phenylketonuria from other forms of hyperphenylalaninemia. I...

journal_title：Clinical chemistry and laboratory medicine

authors： Vallian S,Moeini H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The aim was to investigate whether first trimester glycodelin and angiopoietin-2 can predict small-for-gestational age (SGA) at delivery, individually or in combination. METHODS:In this case-control study we measured glycodelin and angiopoietin-2 on serum from 170 singleton pregnant women delivering SGA neo...

journal_title：Clinical chemistry and laboratory medicine

authors： Hansen YB,Myrhøj V,Jørgensen FS,Sørensen S

更新日期：2016-09-01 00:00:00

abstract：:Technological advances over the past decades have enabled oral fluid to expand its usefulness in the diagnosis of disease, prediction of disease progression, monitoring of therapeutic drug levels and detection of illicit drugs. The easy non-invasive nature of collection and the relationship between oral fluid and plas...

journal_title：Clinical chemistry and laboratory medicine

authors： Choo RE,Huestis MA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively contain RNA (small RNAs and mRNAs) and harbor unique subset of proteins, r...

journal_title：Clinical chemistry and laboratory medicine

authors： Channavajjhala SK,Rossato M,Morandini F,Castagna A,Pizzolo F,Bazzoni F,Olivieri O

更新日期：2014-03-01 00:00:00

abstract：:We estimated the frequencies of phenotype (isoelectric focusing; IEF) vs. genotype (PCR/Hhal) discordance in a sample of an aged population (> 65 years). Both phenotype and genotype techniques have been used in the study of apolipoprotein E (apoE) polymorphism in 125 elderly subjects. The discordance between phenotype...

journal_title：Clinical chemistry and laboratory medicine

authors： Dupuy AM,Badiou S,Ritchie K,Mas E,Descomps B,Cristol JP,Touchon J

更新日期：2001-05-01 00:00:00

abstract：:Cardiovascular risk is associated with high lipoprotein(a) (Lp(a)) concentrations and low molecular weight apolipoprotein(a) (apo(a)) isoforms. We studied the relationship between these two biological parameters, particularly in subjects expressing two apo(a) isoforms. Plasma Lp(a) was measured by immunonephelometry i...

journal_title：Clinical chemistry and laboratory medicine

authors： Alaoui M,Merle C,Garnotel R,Jolly D,Durlach V,Gillery P

更新日期：2003-05-01 00:00:00

abstract：:We report on the performance of a new test, holotranscobalamin, as compared to well established markers of vitamin B12 deficiency (plasma cobalamins, methylmalonic acid, and homocysteine). Holotranscobalamin was analyzed in 143 samples by a competitive radiobinding assay (Axis-Shield). Employing a cut-off value of 50 ...

journal_title：Clinical chemistry and laboratory medicine

authors： Hvas AM,Nexo E

更新日期：2003-11-01 00:00:00

abstract：:Translational research and translational medicine (referred to hereafter as translational research) are interchangeable terms that underline the pressing need to translate into practical benefits for those affected by disease the extensive investments divested by the private and public sectors in biomedical research. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Plebani M,Marincola FM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Adult-type hypolactasia is characterized by the inability to digest lactose during adulthood, due to lactase (LCT) deficiency. It is usually diagnosed by the measurement of breath hydrogen increase after a lactose load (breath hydrogen test, BHT). A substitution of C to T at position -13910 bp upstream the L...

journal_title：Clinical chemistry and laboratory medicine

authors： Mottes M,Belpinati F,Milani M,Saccomandi D,Petrelli E,Calacoci M,Chierici R,Pignatti PF,Borgna-Pignatti C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00