Development and validation of a high performance liquid chromatography method to determine linezolid concentrations in pig pulmonary tissue.

abstract：:The acute-phase "panproteinase" inhibitor alpha2-macroglobulin (alpha2M), a protein involved in inflammatory reactions, has been identified in amyloid plaques in Alzheimer's disease (AD). In addition, alpha2M is involved in AD susceptibility at the genetic level, and a deletion polymorphism at the a2M gene has been fo...

journal_title：Clinical chemistry and laboratory medicine

authors： Scacchi R,Ruggeri M,Gambina G,Martini MC,Corbo RM

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia (Hhcy) is considered an independent risk factor for vascular diseases and, more recently, for dementia. The methionine loading test (MLT) is useful for diagnosing additional subjects with moderate Hhcy. However, it is a complex and time-consuming procedure. A noninvasive test for the dia...

journal_title：Clinical chemistry and laboratory medicine

authors： Maldonado-Hernández J,Prina-Ojeda LV,Montalvo-Velarde I,Del Prado-Manríquez M,de Lourdes Barbosa-Cortés M,Repetto-Madrid M

更新日期：2014-05-01 00:00:00

abstract：:There is no comprehensive study on the stability of coagulation analytes in plasma. We therefore determined the influence of storage time and temperature on prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, factors V and VIII, antithrombin III, protein C and S in plasma from 20 health...

journal_title：Clinical chemistry and laboratory medicine

authors： Heil W,Grunewald R,Amend M,Heins M

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Apolipoprotein A-I gene (APOA1) polymorphisms have been associated with variations in serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol. We have investigated whether APOA1 common variants are also associated with variations in basal triglyceride serum concentrations and resp...

journal_title：Clinical chemistry and laboratory medicine

authors： Sorkin SC,Forestiero FJ,Hirata MH,Guzmán EC,Cavalli SA,Bertolami MC,Salazar LA,Hirata RD

更新日期：2005-01-01 00:00:00

abstract：:Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% an...

journal_title：Clinical chemistry and laboratory medicine

authors： Bonnet E,Genoux A,Bernard J,Fauvel J,Massip P,Perret B

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mo...

journal_title：Clinical chemistry and laboratory medicine

authors： Kurt YG,Cayci T,Onguru P,Akgul EO,Yaman H,Aydin I,Bodur H,Turker T,Kurt I,Cevik MA,Erbil MK

更新日期：2009-01-01 00:00:00

abstract：:The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 af...

journal_title：Clinical chemistry and laboratory medicine

authors： Milani P,Valentini V,Ferraro G,Basset M,Russo F,Foli A,Palladini G,Merlini G

更新日期：2016-06-01 00:00:00

abstract：:An outbreak of the so-called Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has been spreading rapidly nationwide in China since December 2019. Wuhan, Hubei Province, is the hardest-hit region, with a rise in confirmed cases and its hospitals overwhelme...

journal_title：Clinical chemistry and laboratory medicine

authors： Yusong L,Duanliang P,Jia Y,Dunyan C,Hongbing J,Siyuan Y,Huanhuan C,Juan Z,Lyurong L

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:The stability limit of an analyte in a biological sample can be defined as the time required until a measured property acquires a bias higher than a defined specification. Many studies assessing stability and presenting recommendations of stability limits are available, but differences among them are frequen...

journal_title：Clinical chemistry and laboratory medicine

authors： Gómez Rioja R,Martínez Espartosa D,Segovia M,Ibarz M,Llopis MA,Bauça JM,Marzana I,Barba N,Ventura M,García Del Pino I,Puente JJ,Caballero A,Gómez C,García Álvarez A,Alsina MJ,Álvarez V

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:The IFCC Task Force on Clinical Applications of Cardiac Biomarkers suggests comparing several contemporary sensitive troponin assays in the same, sufficiently large reference population. METHODS:Three contemporary sensitive assays were used to measure troponin I concentration in samples from a uniquely larg...

journal_title：Clinical chemistry and laboratory medicine

authors： Petersmann A,Ittermann T,Fries C,Lubenow N,Kohlmann T,Kallner A,Greinacher A,Nauck M

更新日期：2013-11-01 00:00:00

abstract：:Since serum and plasma D-dimer concentrations correlate very well, we evaluated the comparability of other haemostasis activation markers in plasma and serum. Prothrombin fragment F1+2, fibrin monomer and D-dimer concentrations were measured with commercially available immunoassays in serum and plasma. Serum to plasma...

journal_title：Clinical chemistry and laboratory medicine

authors： Korte W,Riesen WF

更新日期：2001-07-01 00:00:00

abstract：:Recent studies demonstrated that large amounts of the pro-hormone peptide of brain natriuretic peptide (proBNP) can be detected in plasma of healthy subjects and in particular of patients with heart failure. As a result, a great part of B-type natriuretic peptides measured in patients with cardio-vascular disease may ...

journal_title：Clinical chemistry and laboratory medicine

authors： Clerico A,Vittorini S,Passino C

更新日期：2011-08-26 00:00:00

abstract：Background:Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based assays are employed in more and more clinical laboratories to quantify steroids. The steroid quantification by LC-MS/MS shows great value in screening or diagnosing endocrine disorders; however, the number of functional steroids included in the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang Z,Wang H,Peng Y,Chen F,Zhao L,Li X,Qin J,Li Q,Wang B,Pan B,Guo W

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:The identification of human mitochondrial DNA (mtDNA) sequence variations, especially single nucleotide polymorphisms (SNPs), is important for many applications. The PCR-ligase detection reaction (LDR) method can reduce false-positives and eliminate the need for both post-PCR and post-ligation purifications ...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo Y,Tang S,Gao W,Chen L,Yang X,Huang T,Gao Y

更新日期：2010-04-01 00:00:00

abstract：:The methods for detecting and measuring autoantibodies have evolved markedly in recent years, encompassing three generations of analytical technologies. Many different immunoassay methods have been developed and used for research and laboratory practice purposes, from the early conventional (or monoplex) analytical me...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,Bonaguri C,Melegari A,Antico A,Bassetti D,Bizzaro N

更新日期：2013-01-01 00:00:00

abstract：:We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique. Insulin action, as evaluated by glu...

journal_title：Clinical chemistry and laboratory medicine

authors： Stanická S,Vondra K,Pelikánová T,Vlcek P,Hill M,Zamrazil V

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Iodine requirements increase during pregnancy and previous studies have reported the inadequate iodine status of pregnant women in areas that have achieved iodine sufficiency in the general population. We examined the urinary iodine (UI) concentrations of pregnant women in Ukraine, where the iodine status is...

journal_title：Clinical chemistry and laboratory medicine

authors： Sekitani Y,Hayashida N,Takahashi J,Kozlovsky AA,Rudnitskiy S,Petrova A,Gutevych OK,Chorniy SA,Yamashita S,Takamura N

更新日期：2013-04-01 00:00:00

abstract：:Early diagnosis of cobalamin deficiency is crucial, owing to the latent nature of this disorder and the resulting possible irreversible neurological damage. A normal serum cobalamin concentration does not reliably rule out a functional cobalamin deficiency and there does not at present seem to be any single diagnostic...

journal_title：Clinical chemistry and laboratory medicine

authors： Nilsson K,Isaksson A,Gustafson L,Hultberg B

更新日期：2004-01-01 00:00:00

abstract：:The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chemotherapy for metastati...

journal_title：Clinical chemistry and laboratory medicine

authors： Sölétormos G,Petersen PH,Dombernowsky P

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS:In a prospective...

journal_title：Clinical chemistry and laboratory medicine

authors： Behnes M,Papassotiriou J,Walter T,Fiedler E,Sauer T,Lang S,Elmas E,Hoffmann U,Borggrefe M,Brueckmann M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The objective of the study was to find the incidence of hemolysis in samples transported through a pneumatic tube system (PTS) at different speeds. METHODS:This prospective observational study was done in three phases: "short distance and high speed (115 m at 3 m/s)", "long distance and high speed (225 m at...

journal_title：Clinical chemistry and laboratory medicine

authors： Tiwari AK,Pandey P,Dixit S,Raina V

更新日期：2011-11-10 00:00:00

abstract：Objectives:The utilization of reliable quality indicators (QIs) proven to be suitable for monitoring and improvement tools is one of the best choices to minimize of the risk of errors in all laboratory processes called as total testing process (TTP). In 2008, a Working Group "Laboratory Errors and Patient Safety" (WG-L...

journal_title：Clinical chemistry and laboratory medicine

authors： Orhan B,Sonmez D,Cubukcu HC,Zengi O,Ozturk Emre H,Cinaroglu I,Keles M,Gumus A,Coskun C

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:The biochemical determination of cardiac natriuretic peptides, primarily brain natriuretic peptide (BNP) and the amino-terminal fragment of its pro-hormone proBNP (NT-proBNP), are reliable tools for diagnosing cardiac disease, establishing prognosis and evaluating the effectiveness of treatment. These biomar...

journal_title：Clinical chemistry and laboratory medicine

authors： Zaninotto M,Mion MM,Di Serio F,Caputo M,Ottomano C,Plebani M

更新日期：2010-07-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is present in more than 90% of patients with congenital adrenal hyperplasia, an inherited metabolic disorder of adrenal steroidogenesis. Impaired enzymatic activity leads to the accumulation of metabolic intermediates (progesterone and 17-hydroxyprogesterone), which results in excessi...

journal_title：Clinical chemistry and laboratory medicine

authors： Concolino P,Mello E,Zuppi C,Capoluongo E

更新日期：2010-08-01 00:00:00

abstract：:In view of the role of pharmacotherapy in medicine, on the one hand, and the powerful technical possibilities that are now available on the other hand, therapeutic drug monitoring is a surprisingly neglected area of laboratory medicine. In this viewpoint article, an "omics approach" to pharmacovigilance and drug monit...

journal_title：Clinical chemistry and laboratory medicine

authors： Vogeser M

更新日期：2020-05-05 00:00:00

abstract：:Increased expression of sialyl Lewis X or A antigens on metastatic cancer cells leads to their selectin-mediated extravasation. Profound fucosylation of the serum microenvironment may be a factor that interrupts adhesion and influences the formation of metastases. In this study we quantitatively analyzed fucosylation ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kossowska B,Ferens-Sieczkowska M,Gancarz R,Passowicz-Muszyńska E,Jankowska R

更新日期：2005-01-01 00:00:00

abstract：:The discovery and development of new biomarkers continues to be an exciting and promising field. Improvement in prediction of risk of developing disease is one of the key motivations in these pursuits. Appropriate statistical measures are necessary for drawing meaningful conclusions about the clinical usefulness of th...

journal_title：Clinical chemistry and laboratory medicine

authors： Pencina MJ,D'Agostino RB,Vasan RS

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP. METHODS:The study population consisted of 104 patients d...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Dagostino C,Buonocore R,Aloe R,Bonaguri C,Fanelli G,Allegri M

更新日期：2017-08-28 00:00:00

abstract：:Background Many of the mobile applications (apps) used for delivering health interventions involve laboratory medicine data. This survey was conducted to search the online market for health apps that manage laboratory medicine data. The aim was to review them and perform a quality evaluation. Methods Apps search crite...

journal_title：Clinical chemistry and laboratory medicine

authors： Jovičić S,Siodmiak J,Watson ID,European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Patient Focused Laboratory Medicine.

更新日期：2019-02-25 00:00:00

abstract：:Portable meters for blood glucose concentrations are used at the patients bedside, as well as by patients for self-monitoring of blood glucose. Even though most devices have important technological advances that decrease operator error, the analytical goals proposed for the performance of glucose meters have been rece...

journal_title：Clinical chemistry and laboratory medicine

authors： Sánchez-Margalet V,Rodriguez-Oliva M,Sánchez-Pozo C,Fernández-Gallardo MF,Goberna R

更新日期：2005-01-01 00:00:00