A patient with AL amyloidosis with negative free light chain results.

abstract：:Since PSA is supposed to play an active role in the progression of prostate cancer, we applied a quantitative RT-PCR to measure the absolute levels of prostate-specific antigen (PSA) mRNA expression in benign and malignant prostatic tissue. Consecutive fine needle prostate biopsy material from 59 patients (43 with pro...

journal_title：Clinical chemistry and laboratory medicine

authors： Gelmini S,Tricarico C,Petrone L,Forti G,Amorosi A,Dedola GL,Serio M,Pazzagli M,Orlando C

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Interleukins, interferons and oxidative DNA products are important biomarkers assessing the inflammations and tissue damages caused by toxic materials in the body. We tried to evaluate distributions, reference values and age related changes of blood levels of inflammatory cytokines, C-reactive protein (CRP),...

journal_title：Clinical chemistry and laboratory medicine

authors： Murase T,Kitamura H,Kochi T,Terunuma N,Kurosaki S,Hata K,Yanagi N,Uchino B,Kitahara K,Morimoto Y,Kasai H,Sasaki T,Ogami A,Higashi T

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The possible effects of the uncoupling protein-1 (UCP-1) gene -3826A/G polymorphism on hypertension (HT) have yet to be elucidated. METHODS:A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the -3826A/G ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kotani K,Sakane N,Saiga K,Tsuzaki K,Shimohiro H,Tabata M,Kurozawa Y

更新日期：2007-01-01 00:00:00

abstract：UNLABELLED:The pathogenesis of abdominal aortic aneurysms (AAA) is a complex process in which atherosclerosis and inflammation play a leading role. Cytokines are important mediators of both processes. The aim of our study was to determine whether plasma levels of cytokines which are most involved in AAA pathogenesis ca...

journal_title：Clinical chemistry and laboratory medicine

authors： Treska V,Topolcan O,Pecen L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The dogma of establishing intra-laboratory reference limits (RLs) and their periodic review cannot be fulfilled by most laboratories due to the expenses involved. Thus, most laboratories adopt external sources for their RLs, often neglecting the problems of transferability. This is particularly problematic f...

journal_title：Clinical chemistry and laboratory medicine

authors： Arzideh F,Wosniok W,Haeckel R

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Mutations in BRCA1 and BRCA2 genes are associated with family predisposition to breast and ovarian cancer. Novel screening methods are required for efficient and rapid detection of sequence variants in cancer patients and their family members. METHODS:The screening for variants in the breast and ovarian can...

journal_title：Clinical chemistry and laboratory medicine

authors： Cvok ML,Cretnik M,Musani V,Ozretic P,Levanat S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:We report a Dutch-Belgian multicentre evaluation of the Tosoh HLC-723G8 glycohaemoglobin analyser, an ion-exchange HPLC instrument for the separation and quantification of haemoglobin A1c (HbA1c) in whole blood. METHODS:We evaluated the analytical performances of the Tosoh G8 analyser and compared the resul...

journal_title：Clinical chemistry and laboratory medicine

authors： Chapelle JP,Teixeira J,Maisin D,Assink H,Barla G,Stroobants AK,Delzenne B,van den Eshof W

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The Schwartz 2009 creatinine-based revised formula is the only pediatric GFR estimating formula, which is compatible with the recent global creatinine standardization. This formula is only applicable if enzymatic creatinine methods are used. We propose an equation, taking into account the relative bias cause...

journal_title：Clinical chemistry and laboratory medicine

authors： Speeckaert MM,Wuyts B,Stove V,Walle JV,Delanghe JR

更新日期：2012-03-09 00:00:00

abstract：BACKGROUND:The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incide...

journal_title：Clinical chemistry and laboratory medicine

authors： Nikolopoulos GK,Bagos PG,Tsangaris I,Tsiara CG,Kopterides P,Vaiopoulos A,Kapsimali V,Bonovas S,Tsantes AE

更新日期：2014-07-01 00:00:00

abstract：:The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) formed a Task Force on the Application of Cardiac Bio-markers (TF-CB) in 2008, re-designated in 2018 as a committee (C-CB), to produce educational materials on cardiac biomarkers. Established in June 2017, definitive tables covering the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Collinson PO,Saenger AK,Apple FS,IFCC C-CB.

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:Pertussis has been increasing in frequency and can cause protean manifestation in infants, often resulting in extensive laboratory evaluation. METHODS:We examined the prevalence of cerebrospinal fluid (CSF) anomalies in infants with pertussis and parapertussis over a 5-year period. RESULTS:In total, 239 of...

journal_title：Clinical chemistry and laboratory medicine

authors： Chu TT,Groh J,Cruz AT

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:High-density lipoprotein (HDL) is believed to be protective against coronary heart disease (CHD). HDL is comprised of different subfractions. Of these, HDL 2b is believed to be the most important in preventing CHD. Current methods for HDL subfraction measurements are not standardized and often exhibit poor a...

journal_title：Clinical chemistry and laboratory medicine

authors： Yang DH,Konigshofer Y,Dike J,Chang E,Mueller O

更新日期：2010-06-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:The identification of human mitochondrial DNA (mtDNA) sequence variations, especially single nucleotide polymorphisms (SNPs), is important for many applications. The PCR-ligase detection reaction (LDR) method can reduce false-positives and eliminate the need for both post-PCR and post-ligation purifications ...

journal_title：Clinical chemistry and laboratory medicine

authors： Luo Y,Tang S,Gao W,Chen L,Yang X,Huang T,Gao Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Inflammation plays an imperative role in the etiology of cardiovascular diseases (CVD). The role of cytokines in the development and progression of idiopathic dilated cardiomyopathy (IDCM) is still uncertain. The current study was conducted to evaluate the association of tumor necrosis factor-α (TNF-α) -238G...

journal_title：Clinical chemistry and laboratory medicine

authors： Liaquat A,Shauket U,Ahmad W,Javed Q

更新日期：2015-02-01 00:00:00

abstract：:The mutant of CYP2D6*3 allele with A2637 deletion in exon 5 and the mutant of CYP2D6*4 allele G1934-->A, splice site defect are among the most common polymorphic alleles of CYP2D6 gene, resulting in a decreased or no activity of CYP isoenzyme. In this study, a reliable polymerase chain reaction-restriction fragment le...

journal_title：Clinical chemistry and laboratory medicine

authors： Topić E,Stefanović M,Nikolić V,Zoricić I,Ivanisević AM,Zuntar I

更新日期：1998-08-01 00:00:00

abstract：:There is no comprehensive study on the stability of coagulation analytes in plasma. We therefore determined the influence of storage time and temperature on prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, factors V and VIII, antithrombin III, protein C and S in plasma from 20 health...

journal_title：Clinical chemistry and laboratory medicine

authors： Heil W,Grunewald R,Amend M,Heins M

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:The compatibility of immunoassay tests in different sample matrices is extremely important during the assay validation process. In this study, we investigated the interchangeability of some Access (and therefore all the UniCel Family platforms) assays between serum and plasma. METHODS:We tested approximatel...

journal_title：Clinical chemistry and laboratory medicine

authors： Vignati G,Chiecchio A,Osnaghi B,Giovanelli L,Meloncelli C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The differential diagnosis between bacterial and viral meningitis is not easy in some cases. Cerebrospinal fluid (CSF) analysis is essential for establishing this diagnosis. The objectives were to quantitate lactic acid (LA) concentrations in bacterial and viral meningitis, and other central nervous system (...

journal_title：Clinical chemistry and laboratory medicine

authors： de Almeida SM,Faria FL,de Goes Fontes K,Buczenko GM,Berto DB,Raboni SM,Vidal LR,Nogueira MB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Serum amino acids, part of a pool of free amino acids, are influenced by metabolism and disease. Few reports exist describing their function and concentrations in serum. Our study aimed to determine age- and gender-related differences in serum amino acid concentrations in healthy Japanese patients, focusing ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kouchiwa T,Wada K,Uchiyama M,Kasezawa N,Niisato M,Murakami H,Fukuyama K,Yokogoshi H

更新日期：2012-01-04 00:00:00

abstract：:In order to investigate possible ethnic differences in genetic and environmental determinants, we investigated several cardiovascular disease-associated genetic variations in successful ageing populations of France (Nancy) and China (Hong Kong). Allelic frequencies of these genetic variations were compared between hea...

journal_title：Clinical chemistry and laboratory medicine

authors： Xia Y,Baum L,Pang CP,Siest G,Visvikis S

更新日期：2005-01-01 00:00:00

abstract：:Small dense low-density lipoproteins (LDLs) have been associated with coronary heart disease (CHD) and type 2 diabetes in previous studies. However, the significance of small dense LDLs as a coronary risk factor for subjects with type 2 diabetes remains unclear. We measured mean LDL particle diameter by gradient gel e...

journal_title：Clinical chemistry and laboratory medicine

authors： Yoon Y,Song J,Park HD,Park KU,Kim JQ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The oral glucose tolerance test (OGTT) is recommended to screen for diabetes in patients with coronary artery disease. We hypothesized that testing for glycated hemoglobin (HbA1c), in addition to the OGTT, in screening for abnormal glucose regulation may help to reveal patients with β-cell function impairmen...

journal_title：Clinical chemistry and laboratory medicine

authors： Li YH,Sheu WH,Lee WJ,Lee IT,Lin SY,Lee WL,Liang KW,Wang JS

更新日期：2018-07-26 00:00:00

abstract：:Angiogenesis is a crucial process in tissue remodeling during growth, both in the embryo and the adult. In our study we concentrated on the direct effect of beta-carotene on human umbilical cord originating from endothelial progenitor cells (EPCs). beta-Carotene uptake by EPCs was measured using a HPLC method. The det...

journal_title：Clinical chemistry and laboratory medicine

authors： Kieć-Wilk B,Polus A,Grzybowska J,Mikołajczyk M,Hartwich J,Pryjma J,Skrzeczyńska J,Dembińska-Kieć A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validat...

journal_title：Clinical chemistry and laboratory medicine

authors： Badrnya S,Doherty T,Richardson C,McConnell RI,Lamont JV,Veitinger M,FitzGerald SP,Zellner M,Umlauf E

更新日期：2018-04-25 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is one of the most common viral infections worldwide causing major human chronic pathology. Viral RNA can be detected 1-3 weeks after infection and in cases where HCV RNA is still detectable after 6 months, the patient is considered to be chronically infected. Early detection is cruci...

journal_title：Clinical chemistry and laboratory medicine

authors： Bashiardes S,Richter J,Christodoulou CG

更新日期：2008-01-01 00:00:00

abstract：:Microsatellite typing is frequently used in disease diagnosis and in genetic association studies. Inter-study consistency and comparability is essential in both applications. In this study, we show that the interlaboratory comparison of microsatellite sizes is often discrepant and misleading. This is a matter of great...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossouw M,Warren R,Hoal EG

更新日期：2002-09-01 00:00:00

abstract：:The annual inter- and intra-individual biological variation, including the circannual rhythmic variation, of the serum concentrations of magnesium and ionized calcium has been investigated in a group of 51 apparently healthy volunteers. Venous blood specimens were collected on intervals of once a month within a one-ye...

journal_title：Clinical chemistry and laboratory medicine

authors： Valero-Politi J,Ginard-Salvá M,González-Alba JM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Over the last few decades, new synthetic insulin analogues have been developed. Their measurement is of prime importance in the investigation of hypoglycaemia, but their quantification is hampered by variable cross-reactivity with many insulin assays. For clinical analysis, it has now become essential to kno...

journal_title：Clinical chemistry and laboratory medicine

authors： Heurtault B,Reix N,Meyer N,Gasser F,Wendling MJ,Ratomponirina C,Jeandidier N,Sapin R,Agin A

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Whereas N-terminal pro-brain natriuretic peptide (NT-proBNP) is approved for risk stratification of patients with acute coronary syndromes (ACS), short-term temporal changes in NT-proBNP concentrations and the optimal time points for sampling are not clear. The purpose of this study was to better define the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Buchner S,Debl K,Barlage S,Griese D,Fredersdorf S,Jeron A,Lubnow M,Müller T,Muders F,Holmer S,Riegger GA,Luchner A

更新日期：2010-06-01 00:00:00