Different biological matrices (serum and plasma) utilization in consolidation processes: evaluation of seven Access immunoassays.

abstract：BACKGROUND:Recent studies show that platelets have important roles in the immune system. Little is known about the clinical significance of platelet indices. Changes in platelet indices, including platelet distribution width (PDW), mean platelet volume (MPV) and plateletcrit, in pulmonary tuberculosis were investigated...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozkoparan E,Deniz O,Ucar E,Bilgic H,Ekiz K

更新日期：2007-01-01 00:00:00

abstract：:Recent studies demonstrated that large amounts of the pro-hormone peptide of brain natriuretic peptide (proBNP) can be detected in plasma of healthy subjects and in particular of patients with heart failure. As a result, a great part of B-type natriuretic peptides measured in patients with cardio-vascular disease may ...

journal_title：Clinical chemistry and laboratory medicine

authors： Clerico A,Vittorini S,Passino C

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Efficient laboratory service is the cornerstone of modern health care systems. Scientific innovations have contributed to substantial improvements in the field of laboratory science, but errors still prevail. These errors are classified as preanalytical, analytical and postanalytical, depending upon the time...

journal_title：Clinical chemistry and laboratory medicine

authors： Goswami B,Singh B,Chawla R,Mallika V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Gastrointestinal toxicity is the principal toxicity of chemoradiation in the treatment of rectal carcinoma. The assessment of this toxicity still relies mostly on the symptoms reported by the patient. METHODS:Plasma citrulline, serum neopterin and urinary neopterin were followed weekly in 49 patients with r...

journal_title：Clinical chemistry and laboratory medicine

authors： Zezulová M,Bartoušková M,Hlídková E,Adam T,Kujovská Krčmová L,Červinková B,Solichová D,Zlevorová M,Cwiertka K,Friedecký D,Vrána D,Melichar B

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The purpose of an external quality assessment (EQA) is to evaluate the analytical capability of clinical laboratories, identify differences among the laboratories and improve analytical quality. Our EQA results show that the rates of unsatisfactory performance for thyroid hormone tests were the highest in al...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhou Q,Li S,Li X,Wang W,Wang Z

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Established general risk score models for intensive care patients incorporate several clinical and laboratory data. However, the collection, documentation and classification of clinical data are time-consuming, incur labor-related costs, and are dependent on the experience of the examiner. Therefore, in the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stachon A,Segbers E,Hering S,Kempf R,Holland-Letz T,Krieg M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The handling of cerebrospinal fluid (CSF) affects the biomarker quantification used to diagnose Alzheimer's disease (AD). Only specialized centers can test for AD markers. The precise timing and freezing is required to correctly measure these biomarkers. Therefore, the effects of CSF storage temperature and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Klener J,Hofbauerová K,Bartoš A,Ríčný J,Rípová D,Kopecký V

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Aging is the result of several mechanisms which operate simultaneously. Among them, glycation is of particular interest because it is a reaction which affects slowly renewing tissues and macromolecules with elevated half-life, like the dermis, a skin compartment highly affected by aging. Glycation produces c...

journal_title：Clinical chemistry and laboratory medicine

authors： Pageon H,Zucchi H,Rousset F,Monnier VM,Asselineau D

更新日期：2014-01-01 00:00:00

abstract：:There is some evidence from recent observational studies that hyperhomocysteinemia is a risk factor for cognitive dysfunction, including Alzheimer's disease and vascular dementia. There are only a few intervention studies, and the results are disappointing for such a frequent disease. Prospective double-blind and plac...

journal_title：Clinical chemistry and laboratory medicine

authors： Joosten E

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is a risk factor for ischemic heart disease. Several other mechanisms apply also to dilative types of heart failure of various, non-ischemic etiologies. We hypothesized that hyperhomocysteinemia is associated with left ventricular (LV) dilatation and hypertrophy in dilative cardiomyopath...

journal_title：Clinical chemistry and laboratory medicine

authors： Alter P,Rupp H,Rominger MB,Figiel JH,Renz H,Klose KJ,Maisch B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Galectin-3 is an emerging biomarker of heart failure and of myocardial fibrosis risk. Monitoring of galectin-3 is essential during treatment with galectin-3 inhibitors. The aim of our study was to assess long-term biological variability in a specific group of unhealthy subjects. METHODS:The biological varia...

journal_title：Clinical chemistry and laboratory medicine

authors： Franeková J,Kubíček Z,Hošková L,Kotrbatá M,Sečník P,Kautzner J,Jabor A

更新日期：2015-01-01 00:00:00

abstract：:Soluble transferrin receptor (sTfR) is reported to be a reliable marker for the diagnosis of iron deficiency, especially when iron metabolism is influenced by inflammatory disorders such as infection, chronic inflammation and cancer-related anemia. In the present multicenter study the analytical performance of a recen...

journal_title：Clinical chemistry and laboratory medicine

authors： Kolbe-Busch S,Lotz J,Hafner G,Blanckaert NJ,Claeys G,Togni G,Carlsen J,Röddiger R,Thomas L

更新日期：2002-05-01 00:00:00

abstract：:Background For pregnant women with suspected preeclampsia, the soluble fms-like tyrosine-kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio is a biomarker to aid diagnosis. We performed method comparisons between Elecsys® and Kryptor sFlt-1 and PlGF immunoassays and assessed the diagnostic performance for preeclam...

journal_title：Clinical chemistry and laboratory medicine

authors： Stepan H,Hund M,Dilba P,Sillman J,Schlembach D

更新日期：2019-08-27 00:00:00

abstract：BACKGROUND:Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smo...

journal_title：Clinical chemistry and laboratory medicine

authors： Bamonti F,Novembrino C,Ippolito S,Soresi E,Ciani A,Lonati S,Scurati-Manzoni E,Cighetti G

更新日期：2006-01-01 00:00:00

abstract：:Neopterin is elevated in infections, autoimmune diseases and post-transplant. Recently neopterin elevation was linked to stress response and malignancy. To determine early changes of serum neopterin caused by surgical stress and to investigate their association with other inflammatory markers and with malignancy, we m...

journal_title：Clinical chemistry and laboratory medicine

authors： Jerin A,Pozar-Lukanovic N,Sojar V,Stanisavljevic D,Paver-Erzen V,Osredkar J

更新日期：2002-07-01 00:00:00

abstract：:Over the past decades, the randomized controlled trial has entered an era of continuous improvement and has gradually become accepted as the most effective way of determining the relative efficacy and toxicity of new therapies because it controls for placebo and time effects. However, even sensitive and properly desig...

journal_title：Clinical chemistry and laboratory medicine

authors： Cleophas TJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:CD4+CD25+ forkhead box P3 (FOXP3)+ regulatory T cells (Tregs) accumulate in malignant tumors and negatively regulate antitumor immunity. However, the clinical significance of Tregs in HCC remains unclear. To determine the prognostic value of Tregs, we conducted a retrospective study on 264 patients with Barc...

journal_title：Clinical chemistry and laboratory medicine

authors： Li F,Guo Z,Lizée G,Yu H,Wang H,Si T

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:The pathogenesis of abdominal aortic aneurysms (AAA) is a complex process in which atherosclerosis and inflammation play a leading role. Cytokines are important mediators of both processes. The aim of our study was to determine whether plasma levels of cytokines which are most involved in AAA pathogenesis ca...

journal_title：Clinical chemistry and laboratory medicine

authors： Treska V,Topolcan O,Pecen L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Knowledge of the fatty acid composition of lipid classes in human plasma is an important factor in the investigation of human metabolism. Therefore, a method for the analysis of neutral lipid (NL), phospholipid (PL) and free fatty acids (FFA) in human plasma has been developed and validated. METHODS:Separat...

journal_title：Clinical chemistry and laboratory medicine

authors： Firl N,Kienberger H,Hauser T,Rychlik M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Insulin-like growth factors (IGFs) are believed to be important in brain development and repair following neuronal damage. It is also speculated that IGFs are involved in the association of foetal and pre-adult growth with schizophrenia (SZ). METHODS:The aim of this study was to assess levels of IGF-I, IGF-...

journal_title：Clinical chemistry and laboratory medicine

authors： Akanji AO,Ohaeri JU,Al-Shammri SA,Fatania HR

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Plasma non-esterified (free) fatty acid concentrations rise as a consequence of stimulated endogenous lipolysis and are inversely related to the plasma magnesium concentration when plasma adrenaline concentration is increased. The aim of the study was to test whether high plasma non-esterified fatty acid conc...

journal_title：Clinical chemistry and laboratory medicine

authors： de Valk HW,Bianchi R,van Rijn HJ,Erkelens DW

更新日期：1998-02-01 00:00:00

abstract：:Progression of atherosclerosis is currently believed to involve interactions between leukocytes and vascular endothelium. Epidemiological risk factors for atherosclerosis such as hypertension and smoking are known to cause endothelial dysfunction, which is an early event in the atherosclerotic process; they also may b...

journal_title：Clinical chemistry and laboratory medicine

authors： Mazzone A,Cusa C,Mazzucchelli I,Vezzoli M,Ottini E,Ghio S,Tossini G,Pacifici R,Zuccaro P

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Inflammation plays an imperative role in the etiology of cardiovascular diseases (CVD). The role of cytokines in the development and progression of idiopathic dilated cardiomyopathy (IDCM) is still uncertain. The current study was conducted to evaluate the association of tumor necrosis factor-α (TNF-α) -238G...

journal_title：Clinical chemistry and laboratory medicine

authors： Liaquat A,Shauket U,Ahmad W,Javed Q

更新日期：2015-02-01 00:00:00

abstract：:The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chemotherapy for metastati...

journal_title：Clinical chemistry and laboratory medicine

authors： Sölétormos G,Petersen PH,Dombernowsky P

更新日期：2000-05-01 00:00:00

abstract：:Dementia is a growing public health concern because of the lack of effective curative treatment options and a rising global prevalence. Alzheimer's disease (AD) is the most common type of dementia, affecting 60%-70% of all patients with dementia. The main pathological features of Alzheimer's dementia are neurofibrilla...

journal_title：Clinical chemistry and laboratory medicine

authors： Demarin V,Zavoreo I,Kes VB,Simundić AM

更新日期：2011-05-01 00:00:00

abstract：:It has been well reported over recent years that most errors within the total testing process occur in the pre-analytical phase (46%-68.2%), an area that is usually outside of the direct control of the laboratory and which includes sample collection (phlebotomy). National and international (WHO, CLSI) guidelines recom...

journal_title：Clinical chemistry and laboratory medicine

authors： Cornes M,van Dongen-Lases E,Grankvist K,Ibarz M,Kristensen G,Lippi G,Nybo M,Simundic AM,Working Group for Preanalytical Phase (WG-PRE), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM).

更新日期：2017-01-01 00:00:00

abstract：:Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Met...

journal_title：Clinical chemistry and laboratory medicine

authors： Veenhof H,Koster RA,Alffenaar JC,van den Berg AP,de Groot MR,Verschuuren EAM,Berger SP,Bakker SJL,Touw DJ

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is one of the most common viral infections worldwide causing major human chronic pathology. Viral RNA can be detected 1-3 weeks after infection and in cases where HCV RNA is still detectable after 6 months, the patient is considered to be chronically infected. Early detection is cruci...

journal_title：Clinical chemistry and laboratory medicine

authors： Bashiardes S,Richter J,Christodoulou CG

更新日期：2008-01-01 00:00:00

abstract：Objectives:The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally. The laboratory diagnosis of SARS-CoV-2 infection has relied on nucleic acid testing; however, it has some limitations, such as low throughput and high rates of false negatives. Tests of higher sensitivit...

journal_title：Clinical chemistry and laboratory medicine

authors： Qian C,Zhou M,Cheng F,Lin X,Gong Y,Xie X,Li P,Li Z,Zhang P,Liu Z,Hu F,Wang Y,Li Q,Zhu Y,Duan G,Xing Y,Song H,Xu W,Liu BF,Xia F

更新日期：2020-07-15 00:00:00

abstract：:In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for regist...

journal_title：Clinical chemistry and laboratory medicine

authors： Rizos D,Karababa P,Nikolou C,Sarandakou A,Panagiotakis O,Ferderigou A,Haliassos A,Makris K,Psarra K,Bairaktari E,Spyropoulou P,Galiatsatos N,Trakas N,Seferiadis K,Greek National Clinical Chemistry Registration Commission.

更新日期：2011-08-30 00:00:00