Abstract:
:Dementia is a growing public health concern because of the lack of effective curative treatment options and a rising global prevalence. Alzheimer's disease (AD) is the most common type of dementia, affecting 60%-70% of all patients with dementia. The main pathological features of Alzheimer's dementia are neurofibrillary tangles and senile plaques caused by progressive deposition of β-amyloid in the brain, but its underlying pathological basis is unclear. In common late onset AD sporadic forms (95% of all AD cases), a major genetic risk factor is the apolipoproteinE-ɛ4 (ApoE-ɛ4) alleles, and other genetic determinants have also been proposed to play causative role. This review focuses on biomarkers and subsequent changes in continuous measurement of cognitive and functional abilities in patients with mild cognitive impairment (MCI) and AD that aim to achieve a higher diagnostic accuracy for AD along with clinical assessment, neuropsychological testing and neuroimaging.
journal_name
Clin Chem Lab Medjournal_title
Clinical chemistry and laboratory medicineauthors
Demarin V,Zavoreo I,Kes VB,Simundić AMdoi
10.1515/CCLM.2011.139subject
Has Abstractpub_date
2011-05-01 00:00:00pages
773-8issue
5eissn
1434-6621issn
1437-4331journal_volume
49pub_type
杂志文章,评审abstract::The serum free light chain (FLC) assay has proven to be an important complementary test in the management of patients with monoclonal gammopathies. The serum FLC assay has value for patients with plasma cell disorders in the context of screening and diagnosis, prognostic stratification, and quantitative monitoring. No...
journal_title:Clinical chemistry and laboratory medicine
pub_type: 社论
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journal_title:Clinical chemistry and laboratory medicine
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doi:10.1515/CCLM.2007.058
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1515/cclm-2019-0869
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pub_type: 杂志文章
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1515/CCLM.2002.140
更新日期:2002-08-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type:
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更新日期:2010-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1515/cclm-2012-0397
更新日期:2013-04-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2005.157
更新日期:2005-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
doi:10.1515/CCLM.1999.046
更新日期:1999-03-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/cclm-2018-0220
更新日期:2018-11-27 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2010.102
更新日期:2010-04-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2011.238
更新日期:2011-09-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2003.025
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1515/cclm-2020-0332
更新日期:2020-06-25 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2008.328
更新日期:2008-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2007.268
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF/MS), a laboratory-friendly technique, is used to identify biomarkers for cancer. The aim of the present study was to explore the application of SELDI proteomic patterns in serum for distinguishing between cases of pa...
journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2009.158
更新日期:2009-01-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2000.044
更新日期:2000-04-01 00:00:00
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章,多中心研究
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journal_title:Clinical chemistry and laboratory medicine
pub_type: 杂志文章
doi:10.1515/CCLM.2007.075
更新日期:2007-01-01 00:00:00