C-reactive protein: structural biology and host defense function.

abstract：:This review presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The discussion focuses on the applicability of the methods for the identification of unknown toxic compounds, which is defined as systematic toxicological analysis (...

journal_title：Clinical chemistry and laboratory medicine

authors： Boone CM,Ensing K

更新日期：2003-06-01 00:00:00

abstract：:The present paper describes an evaluation of the interferences found with an immunochemical drug test performed during a workplace control. During the period 1993-2003 more than 200,000 urine samples from workers were examined by the Italian Air Force. Samples were screened for drugs of abuse (opiates, cocaine, cannab...

journal_title：Clinical chemistry and laboratory medicine

authors： De Giovanni N,Fucci N

更新日期：2006-01-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is formed by methylation of arginine residues in proteins and released after proteolysis. In this reaction, S-adenosylmethionine is methyldonor and S-adenosylhomocysteine the demethylated product. ADMA and homocysteine are thus bioch...

journal_title：Clinical chemistry and laboratory medicine

authors： van Guldener C,Nanayakkara PW,Stehouwer CD

更新日期：2007-01-01 00:00:00

abstract：:Surface-enhanced laser desorption time of flight mass spectrometry (SELDI-TOF-MS) is an important proteomic technology that is immediately available for the high throughput analysis of complex protein samples. Over the last few years, several studies have demonstrated that comparative protein profiling using SELDI-TOF...

journal_title：Clinical chemistry and laboratory medicine

authors： Kiehntopf M,Siegmund R,Deufel T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. METHODS:Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational...

journal_title：Clinical chemistry and laboratory medicine

authors： Kovac MK,Lalic-Cosic SZ,Dmitrovic JM,Djordjevic VJ,Radojkovic DP

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Query fever (Q fever) is a zoonotic infection, caused by the intracellular Gram-negative coccobacillus Coxiella burnetii. From 2007 until 2010, a large Q fever outbreak has occurred in the Netherlands. We studied traditional and less common inflammation markers in seronegative and seropositive patients with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Vissers E,de Jager CP,Hilbink M,Kusters R,van Gageldonk-Lafeber AB,Wever PC

更新日期：2012-02-04 00:00:00

abstract：:A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal bl...

journal_title：Clinical chemistry and laboratory medicine

authors： Heidrich JP,Niemeier A,Seyfarth M

更新日期：1998-11-01 00:00:00

abstract：:Drug-induced cardiotoxicity is a major clinical problem; cardiotoxic drugs may induce both cardiac dysfunction and myocardial injury. Several recent studies reported that cardiac troponins measured with high-sensitivity methods (hs-cTn) can enable the early detection of myocardial injury related to chemotherapy or abu...

journal_title：Clinical chemistry and laboratory medicine

authors： Cardinale DM,Zaninotto M,Cipolla CM,Passino C,Plebani M,Clerico A

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Ebola virus, an enveloped virus, is the cause of the largest and most complex Ebola virus disease (EVD) outbreak in West Africa. Blood or body fluids of an infected person may represent a biohazard to laboratory workers. Laboratory tests of virus containing specimens should be conducted in referral centres a...

journal_title：Clinical chemistry and laboratory medicine

authors： Tempestilli M,Pucci L,Notari S,Di Caro A,Castilletti C,Rivelli MR,Agrati C,Pucillo LP

更新日期：2015-11-01 00:00:00

abstract：:Over the past decades, the randomized controlled trial has entered an era of continuous improvement and has gradually become accepted as the most effective way of determining the relative efficacy and toxicity of new therapies because it controls for placebo and time effects. However, even sensitive and properly desig...

journal_title：Clinical chemistry and laboratory medicine

authors： Cleophas TJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:There is a need for reference materials (RMs) in the field of genetic testing for verification of test results obtained in patients and probands. For the frequent genetic variation G20210A in the prothrombin gene, it has been shown that purified plasmids containing the gene fragment harbouring the mutation c...

journal_title：Clinical chemistry and laboratory medicine

authors： Gancberg D,Corbisier P,Meeus N,Marki-Zay J,Mannhalter C,Schimmel H

更新日期：2008-01-01 00:00:00

abstract：:Experimental and observational studies support a role of plasma homocysteine levels (tHcy) in coronary artery disease (CAD). In the GENICA (Genetic and Environmental factors In Coronary Atherosclerosis) study, we found that high tHcy predicted cardiovascular mortality in hypertensive, but not in normotensive, patients...

journal_title：Clinical chemistry and laboratory medicine

authors： Rossi GP,Seccia TM,Pessina AC

更新日期：2007-01-01 00:00:00

abstract：:The commutability of 13 control materials was evaluated by performing parallel measurements on two different analysers: a Synchron CX-5 Delta from Beckman-Coulter and a Vitros 950 from Ortho-Clinical Diagnostics. Twenty three clinical chemistry analytes (substrates, electrolytes and enzymatic activities) were determin...

journal_title：Clinical chemistry and laboratory medicine

authors： Brion E,Lessinger JM,Gould N,Leyendecker J,Férard G

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:This study compared automated vs. manual tissue grinding in terms of RNA yield obtained from oral mucosa biopsies. METHODS:A total of 20 patients undergoing uvulectomy for sleep-related disorders and 10 patients undergoing biopsy for head and neck squamous cell carcinoma were enrolled in the study. Samples ...

journal_title：Clinical chemistry and laboratory medicine

authors： Van der Vorst S,Dekairelle AF,Irenge L,Hamoir M,Robert A,Gala JL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Pneumatic tube transport of blood samples reduces turnaround times and labour. However, the preanalytical effects on new clinical chemistry parameters and instruments are not fully known. The aim of this study was to evaluate the effect of pneumatic tube transport on haematology and coagulation parameters, i...

journal_title：Clinical chemistry and laboratory medicine

authors： Wallin O,Söderberg J,Grankvist K,Jonsson PA,Hultdin J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play an important role in tumor invasion and metastasis. This study aimed to determine the serum levels of MMP-2, MMP-9, 130- and 225-kDa gelatinolytic bands and conventional tumor markers, carcinoembryonic antigen (CEA) and cancer antigen (CA) 19...

journal_title：Clinical chemistry and laboratory medicine

authors： Emara M,Cheung PY,Grabowski K,Sawicki G,Wozniak M

更新日期：2009-01-01 00:00:00

abstract：:Background Aberrant kallikrein activity is observed in a number of inflammatory dermatoses. Up-regulation of kallikrein-5 (KLK5) activity leads to uncontrolled skin desquamation and cleavage of proteinase-activated receptor-2 (PAR2), causing the release of pro-inflammatory cytokines and disruption of epidermal barrier...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Paolo CT,Filippou PS,Yu Y,Poda G,Diamandis EP,Prassas I

更新日期：2019-10-25 00:00:00

abstract：:Advanced age-related macular degeneration (AAMD) is a complex sight-threating disease of public health significance. Micro RNAs (miRNAs) have been proposed as biomarkers for AAMD. The presence of certain single nucleotide polymorphisms (SNPs) may influence the explanatory value of these biomarkers. Here we present fin...

journal_title：Clinical chemistry and laboratory medicine

authors： SanGiovanni JP,SanGiovanni PM,Sapieha P,De Guire V

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:As ABO blood type influences the plasma level of coagulation factor VIII (FVIII), it likely also affects activated partial thromboplastin time (aPTT) and thrombin generation assay (TGA) values. Here, we aimed to investigate the effect of ABO type on the normal values of three global coagulation assays: proth...

journal_title：Clinical chemistry and laboratory medicine

authors： Choi Q,Kim JE,Kim SY,Han KS,Kim HK

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Sequencing based mutation screening assays of genes encompassing large numbers of exons could be substantially optimized by multiplex PCR, which enables simultaneous amplification of many targets in one reaction. In the present study, a multiplex PCR protocol originally developed for fragment analysis was ev...

journal_title：Clinical chemistry and laboratory medicine

authors： Horn MP,Mäder-Heinemann G,Andrey G,Largiadèr CR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A5 (CYP3A5) and ABCB1 polymorphisms have been shown to influence tacrolimus (Tc) blood concentrations in the stable phase after organ transplantation. We hypothesized that Tc pharmacokinetics may be affected by genetic mutations subsequent to starting doses. METHODS:We retrospectively analy...

journal_title：Clinical chemistry and laboratory medicine

authors： Mourad M,Wallemacq P,De Meyer M,Brandt D,Van Kerkhove V,Malaise J,Chaïb Eddour D,Lison D,Haufroid V

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The Enhanced Liver Fibrosis (ELF) score combining serum hyaluronan, N-terminal peptide of type III procollagen and tissue inhibitor of metalloproteinase-1, was reported as relevant in predicting liver fibrosis in chronic liver disease and proposed as an alternative to liver biopsy. METHODS:We evaluated the ...

journal_title：Clinical chemistry and laboratory medicine

authors： Guéchot J,Trocmé C,Renversez JC,Sturm N,Zarski JP,ANRS HC EP 23 Fibrostar Study Group.

更新日期：2012-01-13 00:00:00

abstract：BACKGROUND:Asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase plays an important role in endothelial dysfunction processes. Recent studies have linked high ADMA levels with several pathological conditions. The interest as a marker of endothelial dysfunction has increased in...

journal_title：Clinical chemistry and laboratory medicine

authors： Gervasoni J,Bonelli F,Zuppi C,Zappacosta B,Mordente A,Calvani R,Persichilli S

更新日期：2011-09-06 00:00:00

abstract：:Cytokines are key mediators in cell regulation and communication. The concentration of these proteins can rapidly and importantly increase during severe clinical situations. However, current techniques are not adapted to stat measurement, thus making their clinical use limited. In this context, the commercialization o...

journal_title：Clinical chemistry and laboratory medicine

authors： Berthier F,Lambert C,Genin C,Bienvenu J

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Cardiac troponin T (cTnT) has been reported to be a predictor of stroke outcome. We hypothesized that the high-sensitivity cTnT (hs-cTnT) assay is superior to its previous assay generation for stroke outcome prediction. METHODS:cTnT was measured on emergency department admission in 60 consecutive patients (...

journal_title：Clinical chemistry and laboratory medicine

authors： Furtner M,Ploner T,Hammerer-Lercher A,Pechlaner R,Mair J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves' disease (GD). Three varieties of TRAb have been described: stimulating (S-TRAb), blocking (B-TRAb), and apoptotic (A-TRAb) autoantibodies. Very recently, the first immunoassay method (Immulit...

journal_title：Clinical chemistry and laboratory medicine

authors： Tozzoli R,D'Aurizio F,Villalta D,Giovanella L

更新日期：2017-01-01 00:00:00

abstract：:An increasing incidence of male infertility has been noted over the past few decades. This adds urgency to the need to develop immunohistochemical markers for better evaluation of testicular biopsies. We provide evidence that a histopathological evaluation performed according to morphological criteria and assisted by ...

journal_title：Clinical chemistry and laboratory medicine

authors： Bar-Shira Maymon B,Yavetz H,Schreiber L,Paz G

更新日期：2002-03-01 00:00:00

abstract：:Dementia is a growing public health concern because of the lack of effective curative treatment options and a rising global prevalence. Alzheimer's disease (AD) is the most common type of dementia, affecting 60%-70% of all patients with dementia. The main pathological features of Alzheimer's dementia are neurofibrilla...

journal_title：Clinical chemistry and laboratory medicine

authors： Demarin V,Zavoreo I,Kes VB,Simundić AM

更新日期：2011-05-01 00:00:00

abstract：:The history of prealbumin dates back to the early forties and may be divided into three parts, based on a chronological and functional approach. The first part--the discovery and the identification of prealbumin--was essentially based on classical protein chemistry methods. The second--the demonstration of prealbumin ...

journal_title：Clinical chemistry and laboratory medicine

authors： De Nayer P

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. ...

journal_title：Clinical chemistry and laboratory medicine

authors： Toldi G,Stenczer B,Molvarec A,Takáts Z,Beko G,Rigó J Jr,Vásárhelyi B

更新日期：2010-10-01 00:00:00