Immunohistochemistry in the evaluation of spermatogenesis and Sertoli cell's maturation status.


:An increasing incidence of male infertility has been noted over the past few decades. This adds urgency to the need to develop immunohistochemical markers for better evaluation of testicular biopsies. We provide evidence that a histopathological evaluation performed according to morphological criteria and assisted by immunohistochemical staining on consecutive sections enhances the sensitivity and accuracy of the diagnosis based on testicular biopsies from infertile men.


Clin Chem Lab Med


Bar-Shira Maymon B,Yavetz H,Schreiber L,Paz G





Has Abstract


2002-03-01 00:00:00












  • Performance of strip-based glucose meters and cassette-based blood gas analyzer for monitoring glucose levels in a surgical intensive care setting.

    abstract:BACKGROUND:We verified the analytical performance of strip-based handheld glucose meters (GM) for prescription use, in a comparative split-sample protocol using blood gas samples from a surgical intensive care unit (ICU). METHODS:Freestyle Precision Pro (Abbott), StatStrip Connectivity Meter (Nova), ACCU-CHEK Inform I...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Claerhout H,De Prins M,Mesotten D,Van den Berghe G,Mathieu C,Van Eldere J,Vanstapel F

    更新日期:2016-01-01 00:00:00

  • miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD).

    abstract::Advanced age-related macular degeneration (AAMD) is a complex sight-threating disease of public health significance. Micro RNAs (miRNAs) have been proposed as biomarkers for AAMD. The presence of certain single nucleotide polymorphisms (SNPs) may influence the explanatory value of these biomarkers. Here we present fin...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: SanGiovanni JP,SanGiovanni PM,Sapieha P,De Guire V

    更新日期:2017-05-01 00:00:00

  • The clinical impact of screening for gestational diabetes.

    abstract::Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance during pregnancy. In Denmark the health service offers selective screening for GDM, i.e., admission to an oral glucose tolerance test (OGTT) after pre-screening with interview for clinical risk factors for GDM, two capillary fasting blood gluco...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 临床试验,杂志文章


    authors: Schytte T,Jørgensen LG,Brandslund I,Petersen PH,Andersen B

    更新日期:2004-01-01 00:00:00

  • New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia.

    abstract:BACKGROUND:Mutations in BRCA1 and BRCA2 genes are associated with family predisposition to breast and ovarian cancer. Novel screening methods are required for efficient and rapid detection of sequence variants in cancer patients and their family members. METHODS:The screening for variants in the breast and ovarian can...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Cvok ML,Cretnik M,Musani V,Ozretic P,Levanat S

    更新日期:2008-01-01 00:00:00

  • Evaluation of the first fully automated immunoassay method for the measurement of stimulating TSH receptor autoantibodies in Graves' disease.

    abstract:BACKGROUND:Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves' disease (GD). Three varieties of TRAb have been described: stimulating (S-TRAb), blocking (B-TRAb), and apoptotic (A-TRAb) autoantibodies. Very recently, the first immunoassay method (Immulit...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Tozzoli R,D'Aurizio F,Villalta D,Giovanella L

    更新日期:2017-01-01 00:00:00

  • Thrombophilia screening--at the right time, for the right patient, with a good reason.

    abstract::Thrombophilia can be identified in about half of all patients presenting with venous thromboembolism (VTE). Thrombophilia screening for various indications has increased tremendously, but whether the results of such tests help in the clinical management of patients is uncertain. Here, current recommendations for throm...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Stegnar M

    更新日期:2010-12-01 00:00:00

  • Is capillary electrophoresis a method of choice for systematic toxicological analysis?

    abstract::This review presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The discussion focuses on the applicability of the methods for the identification of unknown toxic compounds, which is defined as systematic toxicological analysis (...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Boone CM,Ensing K

    更新日期:2003-06-01 00:00:00

  • Urinary cystatin C as a specific marker of tubular dysfunction.

    abstract:BACKGROUND:Cystatin C (CST3), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized, with the remainder then eliminated in urine. In tubular diseases, it seems sensible to postulate that CST3 degradation would be ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Conti M,Moutereau S,Zater M,Lallali K,Durrbach A,Manivet P,Eschwège P,Loric S

    更新日期:2006-01-01 00:00:00

  • Diagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far.

    abstract::Acute intestinal ischemic injury (i3) is a life-threatening condition with disastrous prognosis, which is currently difficult to diagnose at the early stages of the disease; a rapid diagnosis is mandatory to avoid irreversible ischemia, extensive bowel resection, sepsis and death. The overlapping protein expression of...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Peoc'h K,Nuzzo A,Guedj K,Paugam C,Corcos O

    更新日期:2018-02-23 00:00:00

  • Sensitive detection of EML4-ALK fusion oncoprotein of lung cancer by in situ proximity ligation assay.

    abstract:BACKGROUND:EML4-ALK fusion oncogene has emerged as a novel molecular target in non-small cell lung cancer (NSCLC). Although break-apart fluorescent in situ hybridization (FISH) is the standard method for diagnosis, it is expensive, not readily available and sometimes difficult to interpret. In addition, ALK immunohisto...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Rho JK,Lee H,Park CS,Choi CM,Lee JC

    更新日期:2013-09-01 00:00:00

  • Large differences in laboratory utilisation between hospitals in Sweden.

    abstract::There are large differences in the use of laboratory tests between hospitals in Sweden. These differences are not only due to differences between the patients treated but also to differences in practice. Use of laboratory test seems to reflect local traditions to a large extent. These large variations in practice are ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Larsson A,Palmer M,Hultén G,Tryding N

    更新日期:2000-05-01 00:00:00

  • Y-chromosome short tandem repeat (STR) haplotypes in a Campania population sample.

    abstract::Given the lack of information about Y haplotypes for Campania (southern Italy), we analyzed eight Y short tandem repeats in a sample of males from this region with the aim of establishing a Y-haplotype database that can be used for forensic purposes. The eight Y short tandem repeats were amplified by two PCR multiplex...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Calcagno G,Labruna G,Sacchetti L

    更新日期:2005-01-01 00:00:00

  • Neopterin--an early marker of surgical stress and hypoxic reperfusion damage during liver surgery.

    abstract::Neopterin is elevated in infections, autoimmune diseases and post-transplant. Recently neopterin elevation was linked to stress response and malignancy. To determine early changes of serum neopterin caused by surgical stress and to investigate their association with other inflammatory markers and with malignancy, we m...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Jerin A,Pozar-Lukanovic N,Sojar V,Stanisavljevic D,Paver-Erzen V,Osredkar J

    更新日期:2002-07-01 00:00:00

  • An evaluation of ten external quality assurance scheme (EQAS) materials for the faecal immunochemical test (FIT) for haemoglobin.

    abstract:Objectives:External quality assessment schemes (EQAS) are being established worldwide to support the faecal immunochemical test (FIT) for haemoglobin (Hb). FIT is widely used as a screening test for colorectal cancer and increasingly in assessment of patients presenting with symptoms. EQA for FIT is provided in several...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: O'Driscoll S,Piggott C,Bruce H,Benton SC

    更新日期:2020-08-07 00:00:00

  • A novel machine learning-derived decision tree including uPA/PAI-1 for breast cancer care.

    abstract::Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 and to build a new therapeutic decision tree integrating uPA/PAI-1. Me...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Reix N,Lodi M,Jankowski S,Molière S,Luporsi E,Leblanc S,Scheer L,Ibnouhsein I,Benabu JC,Gabriele V,Guggiola A,Lessinger JM,Chenard MP,Alpy F,Bellocq JP,Neuberger K,Tomasetto C,Mathelin C

    更新日期:2019-05-27 00:00:00

  • Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms.

    abstract::Early diagnosis of cobalamin deficiency is crucial, owing to the latent nature of this disorder and the resulting possible irreversible neurological damage. A normal serum cobalamin concentration does not reliably rule out a functional cobalamin deficiency and there does not at present seem to be any single diagnostic...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 临床试验,杂志文章


    authors: Nilsson K,Isaksson A,Gustafson L,Hultberg B

    更新日期:2004-01-01 00:00:00

  • Nobelitis: a common disease among Nobel laureates?

    abstract::Winning a Nobel Prize is a great personal achievement. Some Nobel laureates may consider that their award is a certificate of competence in any field. This may prompt them to undertake projects or accept positions which are beyond their capabilities. Since Nobels are awarded when the laureates have usually passed thei...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Diamandis EP

    更新日期:2013-08-01 00:00:00

  • Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy.

    abstract::Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% an...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Bonnet E,Genoux A,Bernard J,Fauvel J,Massip P,Perret B

    更新日期:2007-01-01 00:00:00

  • Combining antibody tests and taking into account antibody levels improves serologic diagnosis of celiac disease.

    abstract:BACKGROUND:The European Society for Pediatric Gastroenterology and Nutrition states that if IgA anti-tissue transglutaminase (tTG) exceeds 10 times the upper limit of normal (ULN), there is the possibility to diagnose celiac disease (CD) without duodenal biopsy, if supported by anti-endomysium testing and human leukocy...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Oyaert M,Vermeersch P,De Hertogh G,Hiele M,Vandeputte N,Hoffman I,Bossuyt X

    更新日期:2015-09-01 00:00:00

  • How useful are housekeeping genes? Variable expression in melanoma metastases.

    abstract:BACKGROUND:There is a certain difference in opinion regarding the optimal choice of housekeeping genes used as normalization factors in gene expression analysis. We have therefore examined the suitability of three housekeeping genes, hypoxanthine phosphoribosyl transferase, beta-glucuronidase and beta2-micro-globulin, ...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Kågedal B,Farnebäck M,Håkansson A,Gustafsson B,Håkansson L

    更新日期:2007-01-01 00:00:00

  • Evaluation of serum levels of p53 in hepatocellular carcinoma in Egypt.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-induced death. Somatic mutation of the p53 gene is the most common genetic abnormality so far described in human cancer and there is evidence that supports a high level of p53 alterations in HCC. The aim of this study was to investigate serum le...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: El Far MA,Atwa MA,Yahya RS,El Basuni MA

    更新日期:2006-01-01 00:00:00

  • European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay.

    abstract:BACKGROUND:International recommendations highlight the superior value of cardiac troponins (cTns) for early diagnosis of myocardial infarction along with analytical requirements of improved precision and detectability. In this multicenter study, we investigated the analytical performance of a new high sensitive cardiac...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Krintus M,Kozinski M,Boudry P,Capell NE,Köller U,Lackner K,Lefèvre G,Lennartz L,Lotz J,Herranz AM,Nybo M,Plebani M,Sandberg MB,Schratzberger W,Shih J,Skadberg Ø,Chargui AT,Zaninotto M,Sypniewska G

    更新日期:2014-11-01 00:00:00

  • Haemophilia A: molecular insights.

    abstract::Haemophilia A is the most common inherited bleeding disorder caused by defects in the F8C gene that encodes coagulation factor VIII. This X-linked recessive disorder occurs in approximately 1:5000 males. Haemophilia A is diagnosed based on normal prothrombin time, altered activated partial thromboplastin time and redu...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Castaldo G,D'Argenio V,Nardiello P,Zarrilli F,Sanna V,Rocino A,Coppola A,Di Minno G,Salvatore F

    更新日期:2007-01-01 00:00:00

  • Long-term biological variability of galectin-3 after heart transplantation.

    abstract:BACKGROUND:Galectin-3 is an emerging biomarker of heart failure and of myocardial fibrosis risk. Monitoring of galectin-3 is essential during treatment with galectin-3 inhibitors. The aim of our study was to assess long-term biological variability in a specific group of unhealthy subjects. METHODS:The biological varia...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 临床试验,杂志文章


    authors: Franeková J,Kubíček Z,Hošková L,Kotrbatá M,Sečník P,Kautzner J,Jabor A

    更新日期:2015-01-01 00:00:00

  • Prevalence of atrophic gastritis in dyspeptic patients in Piedmont. A survey using the GastroPanel test.

    abstract:BACKGROUND:Chronic atrophic gastritis (CAG) is a precursor of the intestinal type of gastric cancer, the second leading cause of cancer-related death worldwide. GastroPanel is a recently marketed serological kit for the non-invasive diagnosis of CAG, defined by some authors "even more reliable than biopsy histology". T...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Lombardo L,Leto R,Molinaro G,Migliardi M,Ravarino N,Rocca R,Torchio B

    更新日期:2010-09-01 00:00:00

  • Fluorimetric quantitation of citalopram and escitalopram in plasma: developing an express method to monitor compliance in clinical trials.

    abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) in general, and citalopram/escitalopram in particular, are widely used to treat clinical depression. However, SSRI bioavailability and non-compliance represent major issues, especially in the clinical trials setting. In this context, frequent drug-level measure...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Serebruany V,Malinin A,Dragan V,Atar D,van Zyl L,Dragan A,Lexapro Compliance Task Force.

    更新日期:2007-01-01 00:00:00

  • Factors affecting soluble mesothelin related protein levels in an asbestos-exposed population.

    abstract:BACKGROUND:Soluble mesothelin-related protein (SMRP) is increased in the sera of patients with malignant mesothelioma (MM), and has been suggested as a diagnostic tool for MM in an asbestos exposed population. However, factors affecting SMRP concentrations in normal subjects and those with other asbestos related disord...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Park EK,Thomas PS,Creaney J,Johnson AR,Robinson BW,Yates DH

    更新日期:2010-06-01 00:00:00

  • Quality evaluation of smartphone applications for laboratory medicine.

    abstract::Background Many of the mobile applications (apps) used for delivering health interventions involve laboratory medicine data. This survey was conducted to search the online market for health apps that manage laboratory medicine data. The aim was to review them and perform a quality evaluation. Methods Apps search crite...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Jovičić S,Siodmiak J,Watson ID,European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Patient Focused Laboratory Medicine.

    更新日期:2019-02-25 00:00:00

  • Supportive therapy of the sepsis syndrome.

    abstract::Adequate volume loading may be the most important step in the treatment of patients with septic shock. Techniques allowing us to achieve and tightly control volume loading and regional perfusion are considered to be helpful. An elevated oxygen delivery may be beneficial in some patients but the increase of oxygen deli...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章,评审


    authors: Meier-Hellmann A,Sakka S,Reinhart K

    更新日期:1999-03-01 00:00:00

  • An approach to establish the uncertainty budget of catalytic activity concentration measurements in a reference laboratory.

    abstract:BACKGROUND:Reference laboratories providing reference services recognized by the Joint Committee for Traceability in Laboratory Medicine (JCTLM) must be accredited as calibration laboratories according to ISO 17025 and ISO 15195. These standards require laboratories to establish an uncertainty budget, in which the unce...

    journal_title:Clinical chemistry and laboratory medicine

    pub_type: 杂志文章


    authors: Rami L,Canalias F

    更新日期:2015-04-01 00:00:00